CAS Number22071-15-4
Synonyms2-(3-benzoyl-phenyl)propionic acid; UNII:90Y4QC304K; Epatec; Lertus; Dexal; Menamin; Meprofen; Fastum; MFCD00055790; Orugesic; Iso-K; Oscorel; 2-(m-Benzoylphenyl)propionic acid; Oruvail; 2-(3-Benzoylphenyl)propanoic acid; Kefenid; Ketoflam; Orudis; ru4733; EINECS 244-759-8; Enantyum; 2-(3-benzoylphenyl)propionic acid; aneol
Molecular FormulaC16H14O3
Molecular Weight254.28
Purity≥98 (TLC)%
Density1.2±0.1 g/cm3
Boiling Point431.3±28.0 °C at 760 mmHg
Melting Point93-96°C
Appearancepowder
EINECS244-759-8
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 22071-15-4 |
| Catalog No. | 2A-9011100 |
| Chinese Name | 酮洛芬 |
| Synonyms | 2-(3-benzoyl-phenyl)propionic acid; UNII:90Y4QC304K; Epatec; Lertus; Dexal; Menamin; Meprofen; Fastum; MFCD00055790; Orugesic; Iso-K; Oscorel; 2-(m-Benzoylphenyl)propionic acid; Oruvail; 2-(3-Benzoylphenyl)propanoic acid; Kefenid; Ketoflam; Orudis; ru4733; EINECS 244-759-8; Enantyum; 2-(3-benzoylphenyl)propionic acid; aneol |
| Molecular Formula | C16H14O3 |
| Molecular Weight | 254.28 |
| Purity | ≥98 (TLC) |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 431.3±28.0 °C at 760 mmHg |
| Melting Point | 93-96°C |
| Appearance | powder |
| Water Solubility | Water solubility: virtually insoluble; easily solu |
| Storage Condition | About 0-6℃ Put in a tight storage container |
| Packaging | III |
| Application | Ketoprofen is a non-steroidal anti-inflammatory agent that can effectively inhibit the activity of COX. In human blood mononuclear cells, the IC50 values for COX-1 and COX-2 are 2 nM and 26 nM, resp |
| EINECS | 244-759-8 |
| HTC | 2916392000 |
| PubChem ID | 57654315 |
| MDL Number | MFCD00055790 |
| SMILES | CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2 |
| InChI | 1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19) |
| InChI Key | DKYWVDODHFEZIM-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/11100_1_22071_15_4.pdf |
| Bioactivity | Ketoprofen is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively. Related Catalog Research Areas >> Inflammation/Immunology Target COX-1:2 nM (IC50, in human blood monocytes) COX-2:26 nM (IC50, in human blood monocytes) In Vitro Ketoprofen (Compound 2) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1]. In Vivo Ketoprofen (0.32-10 mg/kg, s.c) dose-dependently inhibits acid-induced depression of nesting (IC50, 2.05 mg/kg), and reverses CFA-induced such depression at 0.1-10 mg/kg, with an IC50 of 0.18 mg/kg in mice[2]. Animal Admin First, Ketoprofen (0.1-1.0 mg/kg) and morphine (0.1-1.0 mg/kg) are evaluated for their effectiveness to block U69,593-induced depression of nesting. For these studies, Ketoprofen or morphine is administered 30 min before nesting, 1.0 mg/kg U69,593 is administered 15 min before nesting, and each set of conditions is tested in a group of six mice[2]. References [1]. Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12(4):533-7. [2]. Negus SS, et al. Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice. Pain. 2015 Jun;156(6):1153-60. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 431.3±28.0 °C at 760 mmHg Melting Point 93-96°C Molecular Formula C16H14O3 Molecular Weight 254.281 Flash Point 228.8±20.5 °C Exact Mass 254.094299 PSA 54.37000 LogP 2.81 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.592 InChIKey DKYWVDODHFEZIM-UHFFFAOYSA-N SMILES CC(C(=O)O)c1cccc(C(=O)c2ccccc2)c1 |
| Use of | Ketoprofen is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively. Properties Articles172 Name ketoprofen Synonym More Synonyms ketoprofen Biological Activity Description Ketoprofen is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively. Related Catalog Research Areas >> Inflammation/Immunology COX-1:2 nM (IC50, in human blood monocytes) COX-2:26 nM (IC50, in human blood monocytes) In Vitro Ketoprofen (Compound 2) is a non-steroidal antiinflammatory agent, acting as a potent inhibitor of COX, with IC50s of 2 nM and 26 nM for COX-1 and COX-2 in human blood monocytes, respectively[1]. References [1]. Palomer A, et al. Structure-based design of cyclooxygenase-2 selectivity into ketoprofen. Bioorg Med Chem Lett. 2002 Feb 25;12(4):533-7. [2]. Negus SS, et al. Effects of ketoprofen, morphine, and kappa opioids on pain-related depression of nesting in mice. Pain. 2015 Jun;156(6):1153-60. Chemical & Physical Properties Molecular Formula C16H14O3 Exact Mass 254.094299 PSA 54.37000 Index of Refraction 1.592 InChIKey DKYWVDODHFEZIM-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Ketoprofen) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Ketoprofen) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Ketoprofen) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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