CAS Number103890-78-4
SynonymsCaldine; Lacipil; MFCD00865936; Lacirex; Lacidipine; Motens
Molecular FormulaC26H33NO6
Molecular Weight455.54
Purity≥98 (HPLC)%
Density1.1±0.1 g/cm3
Boiling Point558.4±50.0 °C at 760 mmHg
Melting Point174-175°C
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 103890-78-4 |
| Catalog No. | 2A-9011112 |
| Chinese Name | 拉西地平 |
| Synonyms | Caldine; Lacipil; MFCD00865936; Lacirex; Lacidipine; Motens |
| Molecular Formula | C26H33NO6 |
| Molecular Weight | 455.54 |
| Purity | ≥98 (HPLC) |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 558.4±50.0 °C at 760 mmHg |
| Melting Point | 174-175°C |
| Appearance | powder |
| Storage Condition | -20?C Freezer |
| Packaging | III |
| Application | Lacidipine (Lacipil, Motens) is an L-type calcium channel blocker. |
| HTC | 2933399090 |
| SMILES | N1C(=C(C(C(=C1C)C(=O)OCC)c2c(cccc2)\C=C\C(=O)OC(C)(C)C)C(=O)OCC)C |
| InChI | 1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,1-7H3/b15-14+ |
| InChI Key | GKQPCPXONLDCMU-CCEZHUSRSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352106 |
| Hazard Symbols | 8 |
| MSDS | msds/11112_1_103890_78_4.pdf |
| Bioactivity | Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Target: Calcium ChannelLacidipine, a novel third-generation dihydropyridine calcium channel blocker, has been demonstrated effective for hypertension. lacidipine protects HKCs against apoptosis induced by ATP depletion and recovery by regulating the caspase-3 pathway [1]. In biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E [2]. lacidipine has some important protective effects on liver of hypertensive irradiated albino rats [3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. Zhang, A., et al., Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem, 2013. 32(4): p. 1040-9. [2]. van Amsterdam, F.T., et al., Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. Free Radic Biol Med, 1992. 12(3): p. 183-7. [3]. Kamal, S.M., Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats. Pak J Biol Sci, 2013. 16(21): p. 1353-7. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 558.4±50.0 °C at 760 mmHg Melting Point 174-175°C Molecular Formula C26H33NO6 Molecular Weight 455.543 Flash Point 291.5±30.1 °C Exact Mass 455.230774 PSA 90.93000 LogP 5.49 Vapour Pressure 0.0±1.5 mmHg at 25°C Index of Refraction 1.540 InChIKey GKQPCPXONLDCMU-CCEZHUSRSA-N SMILES CCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1ccccc1C=CC(=O)OC(C)(C)C Storage condition -20?C Freezer |
| Use of | Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Target: Calcium ChannelLacidipine, a novel third-generation dihydropyridine calcium channel blocker, has been demonstrated effective for hypertension. lacidipine protects HKCs against apoptosis induced by ATP depletion and recovery by regulating the caspase-3 pathway [1]. In biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E [2]. lacidipine has some important protective effects on liver of hypertensive irradiated albino rats [3]. Properties Articles43 Name diethyl 2,6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]phenyl]-1,4-dihydropyridine-3,5-dicarboxylate Synonym More Synonyms Lacidipine Biological Activity Description Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Target: Calcium ChannelLacidipine, a novel third-generation dihydropyridine calcium channel blocker, has been demonstrated effective for hypertension. lacidipine protects HKCs against apoptosis induced by ATP depletion and recovery by regulating the caspase-3 pathway [1]. In biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E [2]. lacidipine has some important protective effects on liver of hypertensive irradiated albino rats [3]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. Zhang, A., et al., Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem, 2013. 32(4): p. 1040-9. [2]. van Amsterdam, F.T., et al., Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. Free Radic Biol Med, 1992. 12(3): p. 183-7. [3]. Kamal, S.M., Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats. Pak J Biol Sci, 2013. 16(21): p. 1353-7. Chemical & Physical Properties Molecular Formula C26H33NO6 Exact Mass 455.230774 PSA 90.93000 Index of Refraction 1.540 InChIKey GKQPCPXONLDCMU-CCEZHUSRSA-N Storage condition -20?C Freezer |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified Lacidipine |
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