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Levocabastine hydrochloride structure, CAS 79547-78-7

Levocabastine hydrochloride

CAS Number79547-78-7

SynonymsR 50,547; levocabastin; Livostin; LEVOCABASTINE HYDROCHLORIDE; Levocabastine HCl; Levocabastine; Levophta; levocobastine; UNII-124XMA6YEI

Molecular FormulaC26H30ClFN2O2

Molecular Weight456.98

Purity99%

Density

Boiling Point611ºC at 760 mmHg

Melting Point

Flash Point

Appearancesolid | white

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9011167 Purity: 99%
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Quality Control of [ 79547-78-7 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number79547-78-7
Catalog No.2A-9011167
Chinese Name左旋多巴
SynonymsR 50,547; levocabastin; Livostin; LEVOCABASTINE HYDROCHLORIDE; Levocabastine HCl; Levocabastine; Levophta; levocobastine; UNII-124XMA6YEI
Molecular FormulaC26H30ClFN2O2
Molecular Weight456.98
Purity99
Boiling Point611ºC at 760 mmHg
Appearancesolid | white
Water SolubilityDMSO: ~10 mg/mL, soluble
Storage Condition2-8°C
ApplicationLevocabastine hydrochloride (R 50547) is a long-acting, highly potent, selective histamine H1 receptor antagonist with antiallergic activity. Levocabastine hydrochloride is also a selective, high-affi
PubChem ID329750038
MDL NumberMFCD07787408
SMILESCl[H].C[C@@H]1CN(CC[C@]1(C(O)=O)c2ccccc2)[C@@H]3CC[C@@](CC3)(C#N)c4ccc(F)cc4
InChI1S/C26H29FN2O2.ClH/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20;/h2-10,19,23H,11-17H2,1H3,(H,30,31);1H/t19-,23-,25-,26-;/m1./s1
InChI KeyOICFWWJHIMKBCD-VALQNVSPSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/11167_1_79547_78_7.pdf
BioactivityLevocabastine (R 50547) hydrochloride is a long acting, highly potent and selective histamine H1-receptor antagonist with anti-allergic activity. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2[1][2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Target H1 Receptor NTR2:17 nM (Ki) In Vivo Levocabastine (0.25 mg/kg; i.p.; twice a day for five successive days; guinea-pigs) inhibits the virus-induced airway hyperresponsiveness, suppresses the influx of broncho-alveolar cells and increase in albumin content, and corrects the reduced chemiluminescence production by broncho-alveolar cells in response to zymosan[1]. In mice that receivedβ-LT, Levocabastine (0.05 mg/kg; i.p.) blocks the anxiolytic effect of β-LT and the number of head-dips decreased[2]. References [1]. Folkerts G, et al. Virus-induced airway hyperresponsiveness in the guinea-pig: possible involvement of histamine and inflammatory cells. Br J Pharmacol. 1993;108(4):1083-1093. [2]. Yamauchi R, et al. Effect of beta-lactotensin on acute stress and fear memory. Peptides. 2006;27(12):3176-3182. Chemical & Physical Properties Boiling Point 611ºC at 760 mmHg Molecular Formula C26H30ClFN2O2 Molecular Weight 456.98000 Flash Point 323.3ºC Exact Mass 456.19800 PSA 64.33000 LogP 5.63398 Appearance of Characters solid | white InChIKey OICFWWJHIMKBCD-SFUPJVRMSA-N SMILES CC1CN(C2CCC(C#N)(c3ccc(F)cc3)CC2)CCC1(C(=O)O)c1ccccc1.Cl Storage condition 2-8°C Water Solubility DMSO: ~10 mg/mL, soluble
Use ofLevocabastine (R 50547) hydrochloride is a long acting, highly potent and selective histamine H1-receptor antagonist with anti-allergic activity. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2[1][2]. Properties Articles31 Name (3S,4R)-1-[4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenylpiperidine-4-carboxylic acid,hydrochloride Synonym More Synonyms Levocabastine hydrochloride Biological Activity Description Levocabastine (R 50547) hydrochloride is a long acting, highly potent and selective histamine H1-receptor antagonist with anti-allergic activity. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2[1][2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Histamine Receptor H1 Receptor NTR2:17 nM (Ki) References [1]. Folkerts G, et al. Virus-induced airway hyperresponsiveness in the guinea-pig: possible involvement of histamine and inflammatory cells. Br J Pharmacol. 1993;108(4):1083-1093. [2]. Yamauchi R, et al. Effect of beta-lactotensin on acute stress and fear memory. Peptides. 2006;27(12):3176-3182. Chemical & Physical Properties Exact Mass 456.19800 PSA 64.33000 LogP 5.63398 Appearance of Characters solid | white InChIKey OICFWWJHIMKBCD-SFUPJVRMSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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