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Levcromakalim structure, CAS 94535-50-9

Levcromakalim

CAS Number94535-50-9

Synonymslevcromakelim; levcromakalim; lemakalim

Molecular FormulaC16H18N2O3

Molecular Weight286.33

Purity98%

Density1.31g/cm3

Boiling Point482.3ºC at 760mmHg

Melting Point

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Cat. No.: 2A-9011162 Purity: 98%
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Quality Control of [ 94535-50-9 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number94535-50-9
Catalog No.2A-9011162
Chinese Name左色满卡林
Synonymslevcromakelim; levcromakalim; lemakalim
Molecular FormulaC16H18N2O3
Molecular Weight286.33
Purity98
Density1.31g/cm3
Boiling Point482.3ºC at 760mmHg
Storage Condition2-8℃
ApplicationLevCromakalim is an ATP-sensitive K+ channel (KATP) activator.
HTC2934999090
MDL NumberC16H18N2O3
SMILESCC1(C)Oc2ccc(C#N)cc2C(N2CCCC2=O)C1O
InChIInChI=1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1
InChI KeyTVZCRIROJQEVOT-CABCVRRESA-N
MSDSmsds/11162_1_94535_50_9.pdf
Use ofLevCromakalim is an ATP-sensitive K+ channel (KATP) activator. Properties Name Levcromakalim,(3S,4R)-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile Synonym More Synonyms Levcromakalim Biological Activity Description LevCromakalim is an ATP-sensitive K+ channel (KATP) activator. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Research Areas >> Cardiovascular Disease K+ channel[1] References [1]. Matsumoto T, et al. Tunicamycin-Induced Alterations in the Vasorelaxant Response in Organ-Cultured Superior Mesenteric Arteries of Rats. Biol Pharm Bull. 2016;39(9):1475-81. [2]. Hong SH, et al. Regulation of myometrial contraction by ATP-sensitive potassium (KATP) channel via activation of SUR2B and Kir 6.2 in mouse. J Vet Med Sci. 2016 Aug 1;78(7):1153-9. [3]. Whidden MA, Altered potassium ATP channel signaling in mesenteric arteries of old high salt-fed rats. J Exerc Nutrition Biochem. 2016 Jun;20(2):58-64. Chemical & Physical Properties Molecular Formula C16H18N2O3 Exact Mass 286.13200 PSA 73.56000 LogP 1.69158 InChIKey TVZCRIROJQEVOT-CABCVRRESA-N Storage condition 2-8℃ Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrroli dinyl)-, (3S-trans)- CAS REGISTRY NUMBER : 94535-50-9 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C16-H18-N2-O3 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 22(Suppl 7),S1425,1994 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 22(Suppl 7),S1425,1994 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 22(Suppl 7),S1425,1994 TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 22(Suppl 7),S1425,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - changes in circulation Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 22(Suppl 7),S1425,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - changes in circulation Cardiac - changes in heart weight Related to Chronic Data - changes in ovarian weight REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 22(Suppl 7),S1425,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Endocrine - changes in adrenal weight Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 22(Suppl 7),S1425,1994 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Endocrine - changes in adrenal weight REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 22(Suppl 7),S1425,1994 Safety Information HS Code 2934999090 Synthetic Route 2-Pyrrolidinone CAS#:616-45-5 (1aR,7aR)-7,7-d... CAS#:65018-90-8 Levcromakalim CAS#:94535-50-9 Literature: Dai, Wen; Li, Jun; Li, Guosong; Yang, Hua; Wang, Lianyue; Gao, Shuang Organic Letters, 2013 , vol. 15, # 16 p. 4138 - 4141 2,2-DIMETHYL-2H... CAS#:33143-29-2 Levcromakalim CAS#:94535-50-9 Literature: Page, Philip C. Bulman; Buckley, Benjamin R.; Heaney, Harry; Blacker, A. John Organic Letters, 2005 , vol. 7, # 3 p. 375 - 377 Cromakalim CAS#:94470-67-4 Levcromakalim CAS#:94535-50-9 (3α,4β)-3-Hydro... CAS#:94535-51-0 Literature: Sun, Ping; Wang, Chunlei; Breitbach, Zachary S.; Zhang, Ying; Armstrong, Daniel W. Analytical Chemistry, 2009 , vol. 81, # 24 p. 10215 - 10226 Precursor & DownStream Precursor 5 CAS#:616-45-5 2-Pyrrolidinone CAS#:33143-29-2 2,2-DIMETHYL-2H... CAS#:94470-67-4 Cromakalim CAS#:33143-92-9 4-[(1,1-Dimethy... DownStream 0
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SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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