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Leuprolide acetate structure, CAS 74381-53-6

Leuprolide acetate

CAS Number74381-53-6

SynonymsProcrin; Leuplin; Leuprolide acetate; TAP-144-SR; ELIGARD; Depo-Lupron; Lucrin; Abbott 43818; Uno-Enantone; Leuprorelin Acetate; Leuprin; Procren Depot; [Des-Gly10,Dleu6, ProNHEt9] LH-RH

Molecular FormulaC61H88N16O14

Molecular Weight1269.450

Purity98%

Density

Boiling Point1720.5ºC at 760 mmHg

Melting Point150-155ºC

Flash Point

Appearancesoft solid

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9011161 Purity: 98%
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Quality Control of [ 74381-53-6 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number74381-53-6
Catalog No.2A-9011161
Chinese Name醋酸亮丙瑞林
SynonymsProcrin; Leuplin; Leuprolide acetate; TAP-144-SR; ELIGARD; Depo-Lupron; Lucrin; Abbott 43818; Uno-Enantone; Leuprorelin Acetate; Leuprin; Procren Depot; [Des-Gly10,Dleu6, ProNHEt9] LH-RH
Molecular FormulaC61H88N16O14
Molecular Weight1269.450
Purity98
Boiling Point1720.5ºC at 760 mmHg
Melting Point150-155ºC
Appearancesoft solid
Storage Condition−20°C
ApplicationLeuprolide acetate is a potent gonadotropin-releasing hormone (GNRH) receptor agonist used to treat prostate cancer, endometriosis, and uterine fibroids.
HTC2937190090
SMILESCC(=O)O.CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1
InChIInChI=1S/C59H84N16O12.C2H4O2/c1-6-63-57(86)48-14-10-22-75(48)58(87)41(13-9-21-64-59(60)61)68-51(80)42(23-32(2)3)69-52(81)43(24-33(4)5)70-53(82)44(25-34-15-17-37(77)18-16-34)71-56(85)47(30-76)74-54(83)45(26-35-28-65-39-12-8-7-11-38(35)39)72-55(84)46(27-36-29-62-31-66-36)73-50(79)40-19-20-49(78)67-40;1-2(3)4/h7-8,11-12,15-18,28-29,31-33,40-48,65,76-77H,6,9-10,13-14,19-27,30H2,1-5H3,(H,62,66)(H,63,86)(H,67,78)(H,68,80)(H,69,81)(H,70,82)(H,71,85)(H,72,84)(H,73,79)(H,74,83)(H4,60,61,64);1H3,(H,3,4)
InChI KeyRGLRXNKKBLIBQS-WFAPNXKYSA-N
Hazard SymbolsTransport
MSDSmsds/11161_2_74381_53_6.pdf
BioactivityLeuprolide acetate is a potent gonadotropin-releasing hormone receptor agonist used for the treatment of prostate cancer, endometriosis, uterine fibroids. Related Catalog Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Peptides Research Areas >> Endocrinology References [1]. Mizutani T, Sugihara A, Nakamuro K, Suppression of cell proliferation and induction of apoptosis in uterine leiomyoma by gonadotropin-releasing hormone agonist (leuprolide acetate). J Clin Endocrinol Metab. 1998 Apr;83(4):1253-5. [2]. Silva AL, Abreu LG, Rosa-e-Silva AC, Leuprolide acetate reduces both in vivo and in vitro ovarian steroidogenesis in infertile women undergoing assisted reproduction. Steroids. 2008 Dec 22;73(14):1475-84. [3]. Guzmán-Soto I, Salinas E, Hernández-Jasso I, Leuprolide acetate, a GnRH agonist, improves experimental autoimmune encephalomyelitis: a possible therapy for multiple sclerosis. Neurochem Res. 2012 Oct;37(10):2190-7. [4]. Gaikwad U, Parle M, Kumar A, Effect of ritanserin and leuprolide alone and combined on marble-burying behavior of mice. Acta Pol Pharm. 2010 Sep-Oct;67(5):523-7. Chemical & Physical Properties Boiling Point 1720.5ºC at 760 mmHg Melting Point 150-155ºC Molecular Formula C61H88N16O14 Molecular Weight 1269.450 Flash Point 994.3ºC Exact Mass 1268.666626 PSA 466.34000 LogP 3.44730 InChIKey RGLRXNKKBLIBQS-WFAPNXKYSA-N SMILES CC(=O)O.CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1 Storage condition −20°C
Use ofLeuprolide acetate is a potent gonadotropin-releasing hormone receptor agonist used for the treatment of prostate cancer, endometriosis, uterine fibroids. Properties Articles55 Name leuprolide acetate Synonym More Synonyms Biological Activity Description Leuprolide acetate is a potent gonadotropin-releasing hormone receptor agonist used for the treatment of prostate cancer, endometriosis, uterine fibroids. Related Catalog Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Research Areas >> Endocrinology References [1]. Mizutani T, Sugihara A, Nakamuro K, Suppression of cell proliferation and induction of apoptosis in uterine leiomyoma by gonadotropin-releasing hormone agonist (leuprolide acetate). J Clin Endocrinol Metab. 1998 Apr;83(4):1253-5. [2]. Silva AL, Abreu LG, Rosa-e-Silva AC, Leuprolide acetate reduces both in vivo and in vitro ovarian steroidogenesis in infertile women undergoing assisted reproduction. Steroids. 2008 Dec 22;73(14):1475-84. [3]. Guzmán-Soto I, Salinas E, Hernández-Jasso I, Leuprolide acetate, a GnRH agonist, improves experimental autoimmune encephalomyelitis: a possible therapy for multiple sclerosis. Neurochem Res. 2012 Oct;37(10):2190-7. [4]. Gaikwad U, Parle M, Kumar A, Effect of ritanserin and leuprolide alone and combined on marble-burying behavior of mice. Acta Pol Pharm. 2010 Sep-Oct;67(5):523-7. Chemical & Physical Properties Molecular Formula C61H88N16O14 Exact Mass 1268.666626 PSA 466.34000 LogP 3.44730 InChIKey RGLRXNKKBLIBQS-WFAPNXKYSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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