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Lercanidipine hydrochloride structure, CAS 132866-11-6

Lercanidipine hydrochloride

CAS Number132866-11-6

SynonymsRenovia; Vasodip; Carmen; Lercadip; Lercan; Lercaton; Lercapin; Lerdip; Cardiovasc; Lercanidipine hydrochloride; Corifeo; Lercanidipine hydrochloride hemihydrate; Lerkamen; Zanicor; Masnidipine hydrochloride; REC 15-2375; Lerzam; MFCD07773089; Zandip; Zanidip; Lercanidipine (hydrochloride)

Molecular FormulaC36H42ClN3O6

Molecular Weight648.19

Purity98%

Density

Boiling Point712.5ºC at 760mmHg

Melting Point175-177ºC

Flash Point

AppearanceOff-white-yellow powder

EINECS

MSDSChineseEnglish

SymbolTransport

Signal WordWarning

Cat. No.: 2A-9011155 Purity: 98%
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Quality Control of [ 132866-11-6 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number132866-11-6
Catalog No.2A-9011155
Chinese Name盐酸乐卡地平
SynonymsRenovia; Vasodip; Carmen; Lercadip; Lercan; Lercaton; Lercapin; Lerdip; Cardiovasc; Lercanidipine hydrochloride; Corifeo; Lercanidipine hydrochloride hemihydrate; Lerkamen; Zanicor; Masnidipine hydrochloride; REC 15-2375; Lerzam; MFCD07773089; Zandip; Zanidip; Lercanidipine (hydrochloride)
Molecular FormulaC36H42ClN3O6
Molecular Weight648.19
Purity98
Boiling Point712.5ºC at 760mmHg
Melting Point175-177ºC
AppearanceOff-white-yellow powder
Water SolubilitySoluble in: methanol
Storage Condition2-8°C
ApplicationLercanidipine hydrochloride is a dihydropyridine calcium channel blocker.
MDL NumberMFCD07773089
SMILESO=C(OC)C1=C(C)NC(C)=C(C(OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)=O)C1C4=CC([N+]([O-])=O)=CC=C4.Cl
InChI1S/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H
InChI KeyWMFYOYKPJLRMJI-UHFFFAOYSA-N
UNSPSC41116107
Hazard SymbolsTransport
MSDSmsds/11155_1_132866_11_6.pdf
BioactivityLercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular risk [1, 2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70. [2]. Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7. Chemical & Physical Properties Boiling Point 712.5ºC at 760mmHg Melting Point 175-177ºC Molecular Formula C36H42ClN3O6 Molecular Weight 648.188 Flash Point 384.7ºC Exact Mass 647.276184 PSA 113.69000 LogP 8.13240 Vapour Pressure 3.77E-20mmHg at 25°C InChIKey WMFYOYKPJLRMJI-UHFFFAOYSA-N SMILES COC(=O)C1=C(C)NC(C)=C(C(=O)OC(C)(C)CN(C)CCC(c2ccccc2)c2ccccc2)C1c1cccc([N+](=O)[O-])c1.Cl Storage condition 2-8°C
Use ofLercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular risk [1, 2]. Properties Articles27 Name Lercanidipine Hydrochloride Synonym More Synonyms Lercanidipine hydrochloride Biological Activity Description Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular risk [1, 2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70. [2]. Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7. Chemical & Physical Properties Exact Mass 647.276184 PSA 113.69000 LogP 8.13240 InChIKey WMFYOYKPJLRMJI-UHFFFAOYSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Lercanidipine hydrochloride hemihydrate) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Lercanidipine hydrochloride hemihydrate) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Lercanidipine hydrochloride hemihydrate) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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