CAS Number87081-35-4
Synonyms2,10,12,16,18-nonadecapentaenoic acid; 7,9,11,15-hexamethyl-8-oxo--yl)-17-ethyl-6-hydroxy-5; antibioticci940; antibioticcl1957a; LEPTOMYCIN B FROM STREPTOMYCES SP; Leptomycin B
Molecular FormulaC33H48O6
Molecular Weight540.73
Purity98.00%
Density1.1±0.1 g/cm3
Boiling Point725.8±60.0 °C at 760 mmHg
Melting Point41-44ºC
AppearanceWhite crystalline solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 87081-35-4 |
| Catalog No. | 2A-9011152 |
| Chinese Name | 来普霉素B |
| Synonyms | 2,10,12,16,18-nonadecapentaenoic acid; 7,9,11,15-hexamethyl-8-oxo--yl)-17-ethyl-6-hydroxy-5; antibioticci940; antibioticcl1957a; LEPTOMYCIN B FROM STREPTOMYCES SP; Leptomycin B |
| Molecular Formula | C33H48O6 |
| Molecular Weight | 540.73 |
| Purity | 98.00 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 725.8±60.0 °C at 760 mmHg |
| Melting Point | 41-44ºC |
| Appearance | White crystalline solid |
| Application | Leptomycin B (CI 940; LMB) is an inhibitor of protein nuclear transport. Leptomycin inactivates CRM1/exportin 1 through covalent modification at cysteine residues. Leptomycin B is a potent antifunga |
| HTC | 2916190090 |
| SMILES | CCC(C=CC1OC(=O)C=CC1C)=CC(C)CC=CC(C)=CC(C)C(=O)C(C)C(O)C(C)CC(C)=CC(=O)O |
| InChI | InChI=1S/C33H48O6/c1-9-28(14-15-29-24(5)13-16-31(36)39-29)19-22(3)12-10-11-21(2)17-25(6)32(37)27(8)33(38)26(7)18-23(4)20-30(34)35/h10-11,13-17,19-20,22,24-27,29,33,38H,9,12,18H2,1-8H3,(H,34,35)/b11-10+,15-14+,21-17+,23-20+,28-19-/t22-,24+,25-,26+,27-,29-,33-/m1/s1 |
| InChI Key | YACHGFWEQXFSBS-PNKVMDAHSA-N |
| MSDS | msds/11152_1_87081_35_4.pdf |
| Use of | Properties Articles93 Name leptomycin B Synonym More Synonyms Leptomycin B Biological Activity Related Catalog Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Membrane Transporter/Ion Channel >> CRM1 References Chemical & Physical Properties Molecular Formula C33H48O6 Exact Mass 540.345093 PSA 100.90000 Index of Refraction 1.542 InChIKey YACHGFWEQXFSBS-PNKVMDAHSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 2,10,12,16,18-Nonadecapentanoic acid, 19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-17-ethy l- 6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo- CAS REGISTRY NUMBER : 87081-35-4 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C33-H48-O6 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Rodent - mouse Leukocyte DOSE/DURATION : REFERENCE : PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 26,253,1985 Safety Information GHS02, GHS06, GHS08 Signal Word Danger Hazard Statements H225-H301-H311-H331-H370 Precautionary Statements P210-P260-P280-P301 + P310-P311 Hazard Codes T: Toxic;F: Flammable; Safety Phrases 7-16-24-33-45 RIDADR UN 1230 3 WGK Germany 3 HS Code 2916190090 Synthetic Route (2R,3S)-1-(benz... 217640-04-5 Leptomycin B 87081-35-4 Literature: Tetrahedron Letters, , vol. 39, # 45 p. 8291 - 8294 (2R,3S)-6-isopr... 217640-00-1 Leptomycin B 87081-35-4 Literature: Tetrahedron Letters, , vol. 39, # 45 p. 8291 - 8294 217640-25-0 Leptomycin B 87081-35-4 Literature: Tetrahedron Letters, , vol. 39, # 45 p. 8291 - 8294 Precursor & DownStream Precursor 3 CAS#:217640-04-5 (2R,3S)-1-(benz... CAS#:217640-11-4 (S)-4-isopropyl... CAS#:217640-14-7 (2S,3R,4S,E)-3-... DownStream 0 |
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