CAS Number100427-26-7
Synonymslercarnidipine; masnidipine; Lercanidipine [INN]; UNII:V7XTJ4R0BH; Lercanil (TN); REC 15-2375; MFCD00867978; UNII-V7XTJ4R0BH; Lercanidipine
Molecular FormulaC36H41N3O6
Molecular Weight648.19
Purity98%
Density1.2±0.1 g/cm3
Boiling Point712.5±60.0 °C at 760 mmHg
Melting Point118-120ºC
AppearanceWhite to light yellow solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 100427-26-7 |
| Catalog No. | 2A-9011154 |
| Chinese Name | 乐卡地平 |
| Synonyms | lercarnidipine; masnidipine; Lercanidipine [INN]; UNII:V7XTJ4R0BH; Lercanil (TN); REC 15-2375; MFCD00867978; UNII-V7XTJ4R0BH; Lercanidipine |
| Molecular Formula | C36H41N3O6 |
| Molecular Weight | 648.19 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 712.5±60.0 °C at 760 mmHg |
| Melting Point | 118-120ºC |
| Appearance | White to light yellow solid |
| Application | Lercanidipine is a calcium channel blocker. |
| HTC | 2942000000 |
| MDL Number | MFCD07773089 |
| SMILES | O=C(OC)C1=C(C)NC(C)=C(C(OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)=O)C1C4=CC([N+]([O-])=O)=CC=C4.Cl |
| InChI | 1S/C36H41N3O6.ClH/c1-24-31(34(40)44-6)33(28-18-13-19-29(22-28)39(42)43)32(25(2)37-24)35(41)45-36(3,4)23-38(5)21-20-30(26-14-9-7-10-15-26)27-16-11-8-12-17-27;/h7-19,22,30,33,37H,20-21,23H2,1-6H3;1H |
| InChI Key | WMFYOYKPJLRMJI-UHFFFAOYSA-N |
| UNSPSC | 41116107 |
| MSDS | msds/11154_1_100427_26_7.pdf |
| Use of | Lercanidipine is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular risk [1, 2]. Properties Name 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Synonym More Synonyms Lercanidipine Biological Activity Description Lercanidipine is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular risk [1, 2]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease References [1]. Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70. [2]. Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine? Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7. Chemical & Physical Properties Molecular Formula C36H41N3O6 Exact Mass 611.299561 PSA 113.69000 Index of Refraction 1.580 InChIKey ZDXUKAKRHYTAKV-UHFFFAOYSA-N Safety Information HS Code 2942000000 Synthetic Route Lercanidipine h... CAS#:132866-11-6 Lercanidipine CAS#:100427-26-7 N-Methyl-3,3-di... CAS#:28075-29-8 Lercanidipine CAS#:100427-26-7 Literature: European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420 UNII:5DU0E310OI CAS#:74936-72-4 Lercanidipine CAS#:100427-26-7 Literature: European Journal of Medicinal Chemistry, , vol. 33, # 5 p. 399 - 420 Precursor & DownStream Precursor 9 CAS#:132866-11-6 Lercanidipine h... CAS#:28075-29-8 N-Methyl-3,3-di... CAS#:74936-72-4 UNII:5DU0E310OI CAS#:100442-33-9 1-(3,3-Diphenyl... DownStream 1 CAS#:132866-11-6 Lercanidipine h... |
| Transport Info | Product Name: Lercanidipine |
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