CAS Number130018-77-8
SynonymsLevocetirizine [INN]; vardenafilH; Vivanza; MFCD04112703; levocarnitine; (2-(4-((R)-(4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic Acid; (2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)acetic acid; (2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid; Vardenafil; (-)-Cetirizine; levocetirizinum; (R)-Cetirizine; Levocetirizine
Molecular FormulaC21H25ClN2O3
Molecular Weight461.81
Purity98.00%
Density1.2±0.1 g/cm3
Boiling Point542.1±45.0 °C at 760 mmHg
Melting Point205-208°C (dec.)
AppearanceWhite to off-white powder or crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 130018-77-8 |
| Catalog No. | 2A-9011170 |
| Chinese Name | 左西替利嗪 |
| Synonyms | Levocetirizine [INN]; vardenafilH; Vivanza; MFCD04112703; levocarnitine; (2-(4-((R)-(4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)acetic Acid; (2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]-1-piperazinyl}ethoxy)acetic acid; (2-{4-[(R)-(4-Chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid; Vardenafil; (-)-Cetirizine; levocetirizinum; (R)-Cetirizine; Levocetirizine |
| Molecular Formula | C21H25ClN2O3 |
| Molecular Weight | 461.81 |
| Purity | 98.00 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 542.1±45.0 °C at 760 mmHg |
| Melting Point | 205-208°C (dec.) |
| Appearance | White to off-white powder or crystal |
| Storage Condition | -20°C Freezer |
| Application | Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistamine and is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity |
| HTC | 2933599090 |
| MDL Number | MFCD07366507 |
| SMILES | Cl.Cl.OC(=O)COCCN1CCN(CC1)[C@H](c2ccccc2)c3ccc(Cl)cc3 |
| InChI | 1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1../s1 |
| InChI Key | PGLIUCLTXOYQMV-GHVWMZMZSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/11170_1_130018_77_8.pdf |
| Use of | Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1]. Properties Name Levocetirizine Synonym More Synonyms Levocetirizine Biological Activity Description Levocetirizine ((R)-Cetirizine) is a third-generation peripheral H1-receptor antagonist. Levocetirizine is an antihistaminic agent which is the R-enantiomer of Cetirizine. Levocetirizine has a higher affinity for the histamine H1-receptor than (S)-Cetirizine and can effectively treat allergic rhinitis and chronic idiopathic urticaria[1]. Related Catalog Research Areas >> Endocrinology H1 receptor References [1]. Lohar P, et al. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats. Biomed Chromatogr. 2019 Dec;33(12):e4672. Chemical & Physical Properties Exact Mass 388.155365 PSA 53.01000 Index of Refraction 1.589 InChIKey ZKLPARSLTMPFCP-OAQYLSRUSA-N Safety Information Hazard Codes Xn HS Code 2933599090 Synthetic Route (R)-2-(2-{4-[(4... 909779-33-5 Levocetirizine 130018-77-8 Literature: US6977301 B1, ; Page/Page column 8 ; levocetirizine ... 1150310-68-1 Levocetirizine 130018-77-8 Literature: Ghislieri, Diego; Green, Anthony P.; Pontini, Marta; Willies, Simon C.; Rowles, Ian; Frank, Annika; Grogan, Gideon; Turner, Nicholas J. Journal of the American Chemical Society, 2013 , vol. 135, # 29 p. 10863 - 10869 (+)-[2-[4-[(4-c... 705289-61-8 Sodium chloroac... Levocetirizine 130018-77-8 Precursor & DownStream Precursor 6 CAS#:1150310-68-1 levocetirizine ... CAS#:3926-62-3 Sodium chloroacetate CAS#:1150310-67-0 (R)-2-[2-[4-[(4... CAS#:300543-56-0 1-[(R)-(4-chlor... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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