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Hydrocortisone structure, CAS 50-23-7

Hydrocortisone

CAS Number50-23-7

SynonymsMedicort; 11b,17,21-Trihydroxyprogesterone; 17a-Hydroxycorticosterone; H-Cort; (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione; 11β,17,21-Trihydroxyprogesterone; Cleiton; Hydrocortisone; MFCD00011654; (11β)-11,17,21-Trihydroxy-pregn-4-ene-3,20-dione; Hydroxycorticosterone; Hydrocort; (11b)-11,17,21-trihydroxypregn-4-ene-3,20-dione; 4-Pregnene-11b,17a,21-triol-3,20-dione; 17-hydroxycorticosterone; Hydrocorticosterone; 11,17,21-trihydroxy-pregn-4-ene-3,20-dione; Hytone; Alacort; Signef; Efcortelin; Hydroxycortisone; Hycort; hidrocortisona; Zenoxone; hydrocortisonum; CCN 90306A; HVB; Hydrocortal; wycort

Molecular FormulaC21H30O5

Molecular Weight362.460

Purity98%

Density1.3±0.1 g/cm3

Boiling Point566.5±50.0 °C at 760 mmHg

Melting Point211-214 °C(lit.)

Flash Point

Appearanceliquid

EINECS

MSDSChineseEnglish

Symbol6.1

Signal WordWarning

Cat. No.: 2A-9010867 Purity: 98%
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Quality Control of [ 50-23-7 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number50-23-7
Catalog No.2A-9010867
Chinese Name氢化可的松
SynonymsMedicort; 11b,17,21-Trihydroxyprogesterone; 17a-Hydroxycorticosterone; H-Cort; (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione; 11β,17,21-Trihydroxyprogesterone; Cleiton; Hydrocortisone; MFCD00011654; (11β)-11,17,21-Trihydroxy-pregn-4-ene-3,20-dione; Hydroxycorticosterone; Hydrocort; (11b)-11,17,21-trihydroxypregn-4-ene-3,20-dione; 4-Pregnene-11b,17a,21-triol-3,20-dione; 17-hydroxycorticosterone; Hydrocorticosterone; 11,17,21-trihydroxy-pregn-4-ene-3,20-dione; Hytone; Alacort; Signef; Efcortelin; Hydroxycortisone; Hycort; hidrocortisona; Zenoxone; hydrocortisonum; CCN 90306A; HVB; Hydrocortal; wycort
Molecular FormulaC21H30O5
Molecular Weight362.460
Purity98
Density1.3±0.1 g/cm3
Boiling Point566.5±50.0 °C at 760 mmHg
Melting Point211-214 °C(lit.)
Appearanceliquid
Storage ConditionThis product is sealed and stored in a dry place a
ApplicationHydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex.
HTC2937210000
PubChem ID24895778
MDL NumberMFCD00011654
SMILESC[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@](O)(C(=O)CO)[C@@]4(C)C[C@H](O)[C@H]23
InChI1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1
InChI KeyJYGXADMDTFJGBT-VWUMJDOOSA-N
NACRES CodeNA.77
UNSPSC12352209
Hazard Symbols6.1
MSDSmsds/10867_1_50_23_7.pdf
BioactivityHydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Natural Products >> Steroids Research Areas >> Inflammation/Immunology Target Human Endogenous Metabolite In Vitro Hydrocortisone (50 nM) shows a dose-dependent down-regulation of GR transcript in hCMEC/D3 cells. Hydrocortisone supplementation of the serum-reduced cell differentiation medium leads to a significant increase in TER across the hCMEC/D3 monolayer[1]. Hydrocortisone-treated Dendritic cells (DCs) show a decreased expression of MHC II molecules, the costimulatory molecule CD86, and the DC-specific marker CD83, as well as a strongly reduced IL-12 secretion. Hydrocortisone-treated DCs inhibit production of IFN-γ but induce an increased release of IL-4 and no change in IL-5[2]. Hydrocortisone reduces postischemic oxidative stress, perfusion pressure, and transudate formation. Hydrocortisone inhibits postischemic shedding of syndecan-1, heparan sulfate, and hyaluronan as is release of histamine from resident mast cells[3]. Cell Assay Cells are plated on top of collagen IV-coated transwell chambers for six-well plates (24 mm diameter, membrane material: polyethylene terephthalate (PET), 0.4 μm pores, pore density 1.6×106 cm2) at densities of 2.5×104 cells cm2 per well. When they have reached confluence at day 5, the different experimental sets of cells are transferred to differentiation medium containing reduced amounts of FCS and treated with TNFα or hydrocortisone as indicated. References [1]. F?rster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49. [2]. Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9. [3]. Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107(5):776-84. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 566.5±50.0 °C at 760 mmHg Melting Point 211-214 °C(lit.) Molecular Formula C21H30O5 Molecular Weight 362.460 Flash Point 310.4±26.6 °C Exact Mass 362.209320 PSA 94.83000 LogP 1.43 Vapour Pressure 0.0±3.5 mmHg at 25°C Index of Refraction 1.595 InChIKey JYGXADMDTFJGBT-VWUMJDOOSA-N SMILES CC12CCC(=O)C=C1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)CO
Use ofHydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex. Properties Articles1583 Name cortisol Synonym More Synonyms Hydrocortisone Biological Activity Description Hydrocortisone is a steroid hormone or glucocorticoid secreted by the adrenal cortex. Related Catalog Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Natural Products >> Steroids Research Areas >> Inflammation/Immunology Human Endogenous Metabolite References [1]. F?rster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586(7):1937-49. [2]. Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108(2):242-9. [3]. Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107(5):776-84. Chemical & Physical Properties Molecular Formula C21H30O5 Exact Mass 362.209320 PSA 94.83000 Index of Refraction 1.595 InChIKey JYGXADMDTFJGBT-VWUMJDOOSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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