CAS Number109889-09-0
Synonyms1-(H)Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide; Kevatril; BIDD:GT0272; Sancuso; [3H]-Granisetron; 1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide; HMS2089P14; granisetron hydrochloride
Molecular FormulaC18H24O1N4
Molecular Weight312.41
Purity98%
Density1.3±0.1 g/cm3
Boiling Point532.0±40.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 109889-09-0 |
| Catalog No. | 2A-9010779 |
| Chinese Name | 格拉司琼 |
| Synonyms | 1-(H)Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide; Kevatril; BIDD:GT0272; Sancuso; [3H]-Granisetron; 1-methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide; HMS2089P14; granisetron hydrochloride |
| Molecular Formula | C18H24O1N4 |
| Molecular Weight | 312.41 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 532.0±40.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | Granisetron is a 5-HT3 receptor antagonist. |
| HTC | 2934999090 |
| MDL Number | MFCD00865550 |
| SMILES | CN1C2CCCC1CC(NC(=O)c1nn(C)c3ccccc13)C2 |
| InChI | InChI=1S/C18H24N4O.ClH/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-4-9-16(15)22(2)20-17;/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23);1H |
| InChI Key | MFWNKCLOYSRHCJ-ZIAGYGMSSA-N |
| MSDS | msds/10779_1_109889_09_0.pdf |
| Use of | Properties Name granisetron Synonym More Synonyms Granisetron Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Natural Products >> Alkaloid Research Areas >> Neurological Disease References [1]. Sanger GJ, Nelson DR. Selective and functional 5-hydroxytryptamine3 receptor antagonism by BRL 43694 (granisetron). Eur J Pharmacol. 1989 Jan 10;159(2):113-24. [2]. Maleki-Dizaji N, Eteraf-Oskouei T, Fakhrjou A, The effects of 5HT3 receptor antagonist granisetron on inflammatory parameters and angiogenesis in the air-pouch model of inflammation. Int Immunopharmacol. 2010 Sep;10(9):1010-6. [3]. Boccia RV, Gordan LN, Clark G, Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized, double-blind, phase III study. Support Care Cancer. 2011 Oct;19(10):1609-17. Chemical & Physical Properties Molecular Formula C18H24N4O PSA 50.16000 Index of Refraction 1.690 InChIKey MFWNKCLOYSRHCJ-ZIAGYGMSSA-N Storage condition -20℃ Safety Information HS Code 2934999090 Synthetic Route Total: 1 Page exo-3-Amino-9-m... CAS#:76272-41-8 1-METHYL-1H-IND... CAS#:106649-02-9 Granisetron CAS#:109889-09-0 Literature: Journal of Medicinal Chemistry, , vol. 33, # 7 p. 1924 - 1929 1-Methyl-3-inda... CAS#:50890-83-0 Granisetron CAS#:109889-09-0 Literature: Journal of Medicinal Chemistry, , vol. 33, # 7 p. 1924 - 1929 Granisetron hyd... CAS#:107007-99-8 Granisetron CAS#:109889-09-0 Precursor & DownStream Precursor 4 CAS#:76272-41-8 exo-3-Amino-9-m... CAS#:106649-02-9 1-METHYL-1H-IND... CAS#:50890-83-0 1-Methyl-3-inda... CAS#:107007-99-8 Granisetron hyd... DownStream 1 CAS#:107007-99-8 Granisetron hyd... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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