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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > Homatropine methyl bromide
Homatropine methyl bromide structure, CAS 80-49-9

Homatropine methyl bromide

CAS Number80-49-9

SynonymsMesopin; Homapin; Arkitropin; Malcotran; EINECS 201-284-0; Homatropine Methylbromide; MFCD00050292; HOMATROPINE METHYL BROMIDE; Novatrin; (3-endo)-3-{[(2R)-2-Hydroxy-2-phenylacetyl]oxy}-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide; Novatropine; Sethyl; Homatropine (methylbromide)

Molecular FormulaC17H24BrNO3

Molecular Weight370.281

Purity98%

Density1.21g/cm3

Boiling Point403.3ºC at 760 mmHg

Melting Point192°C

Flash Point

AppearanceSolid;White to Almost white powder to crystal

EINECS

MSDSChineseEnglish

Symbol6.1

Signal WordWarning

Cat. No.: 2A-9010855 Purity: 98%
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Quality Control of [ 80-49-9 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number80-49-9
Catalog No.2A-9010855
Chinese Name溴甲后马托品
SynonymsMesopin; Homapin; Arkitropin; Malcotran; EINECS 201-284-0; Homatropine Methylbromide; MFCD00050292; HOMATROPINE METHYL BROMIDE; Novatrin; (3-endo)-3-{[(2R)-2-Hydroxy-2-phenylacetyl]oxy}-8,8-dimethyl-8-azoniabicyclo[3.2.1]octane bromide; Novatropine; Sethyl; Homatropine (methylbromide)
Molecular FormulaC17H24BrNO3
Molecular Weight370.281
Purity98
Density1.21g/cm3
Boiling Point403.3ºC at 760 mmHg
Melting Point192°C
AppearanceSolid;White to Almost white powder to crystal
Storage ConditionRoom temperature, dry
PackagingIII
ApplicationHomatropine Methylbromide is a muscarinic receptor AChR antagonist that inhibits WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM respectively.
SMILESC[N+]1(C)C2CCC1CC(OC(=O)C(O)c1ccccc1)C2.[Br-]
InChIInChI=1S/C17H24NO3.BrH/c1-18(2)13-8-9-14(18)11-15(10-13)21-17(20)16(19)12-6-4-3-5-7-12;/h3-7,13-16,19H,8-11H2,1-2H3;1H/q+1;/p-1
InChI KeyFUFVKLQESJNNAN-ZZJGABIISA-M
Hazard Symbols6.1
BioactivityHomatropine Methylbromide is muscarinic AChR antagonist, inhibits endothelial and smooth muscle muscarinic receptors of WKY-E and SHR-E with IC50 of 162.5 nM and 170.3 nM, respectively.target： mAChRIC 50: WKY-E(162.5 nM), SHR-E(170.4nM )In vitro: Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs. Homatropine (20 μM) produces a dose ratio of only 95.0 when combined with hexamethonium in atrium from guinea-pigs.In vivo: : Pre-treatment with homatropine (20 mg/kg) was comparable with atropine (10 mg/kg) in preventing lethality in this rat model of acute OC poisoning. All rats pre-treated with normal saline, atropine 5 mg/kg, and homatropine 10 mg/kg died. Survival in the homatropine (20 mg/kg) and atropine (10 mg/kg) groups was 30% and 40% respectively. Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease References [1]. Sim MK et al. Muscarinic receptors in the aortae of normo- and hypertensive rats: a binding study. Clin Exp Hypertens. 1993 Mar;15(2):409-21. [2]. Bryant SM et al. Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. J Med Toxicol. 2006 Dec;2(4):156-9. [3]. Leung E et al. Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig. Eur J Pharmacol. 1982 May 7;80(1):11-7. Chemical & Physical Properties Density 1.21g/cm3 Boiling Point 403.3ºC at 760 mmHg Melting Point 192°C Molecular Formula C17H24BrNO3 Molecular Weight 370.281 Flash Point 197.7ºC Exact Mass 369.093964 PSA 46.53000 Index of Refraction 1.588 InChIKey FUFVKLQESJNNAN-ZZJGABIISA-M SMILES C[N+]1(C)C2CCC1CC(OC(=O)C(O)c1ccccc1)C2.[Br-]
Use ofProperties Articles16 Name homatropine methylbromide Synonym More Synonyms Homatropine Methylbromide Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Neurological Disease References [1]. Sim MK et al. Muscarinic receptors in the aortae of normo- and hypertensive rats: a binding study. Clin Exp Hypertens. 1993 Mar;15(2):409-21. [2]. Bryant SM et al. Intramuscular ophthalmic homatropine vs. atropine to prevent lethality in rates with dichlorvos poisoning. J Med Toxicol. 2006 Dec;2(4):156-9. [3]. Leung E et al. Modification by hexamethonium of the muscarinic receptors blocking activity of pancuronium and homatropine in isolated tissues of the guinea-pig. Eur J Pharmacol. 1982 May 7;80(1):11-7. Chemical & Physical Properties Molecular Formula C17H24BrNO3 Exact Mass 369.093964 PSA 46.53000 Index of Refraction 1.588 InChIKey FUFVKLQESJNNAN-ZZJGABIISA-M
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: Item 1 Poisons. Homatropine bromide Modification number: 5 Module 14. Shipping information UN number: 1544 Formal shipping name: Alkaloid, solid, not otherwise specified Packing grade: III
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