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Homatropine

Name: Homatropine
Brand: 2A Biotech
SKU: 2A-9010853

CAS Number87-00-3

SynonymsOmatropina [DCIT]; Homatropin; Homotropine; DL-mandelic acid-tropane-3endo-yl ester; Homoatropine; homatropine; Mandelyltropeine; Homatropine [BAN]; Methylhomatropinum; DL-Mandelsaeure-tropan-3endo-ylester; EINECS 201-716-8; homatropine hydrobromide; 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; Mandelytropeine; MFCD00067305

Molecular FormulaC16H21NO3

Molecular Weight311.80

Purity98%

Density1.21 g/cm3

Boiling Point403.3ºC

Melting Point100ºC

MSDSChinese English

Cat. No.: 2A-9010853 Purity: 98%

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Quality Control of [ 87-00-3 ] Purity: 98% SDS Specification MoL

Chemical & Physical Properties
CAS Number	87-00-3
Catalog No.	2A-9010853
Chinese Name	后马托品
Synonyms	Omatropina [DCIT]; Homatropin; Homotropine; DL-mandelic acid-tropane-3endo-yl ester; Homoatropine; homatropine; Mandelyltropeine; Homatropine [BAN]; Methylhomatropinum; DL-Mandelsaeure-tropan-3endo-ylester; EINECS 201-716-8; homatropine hydrobromide; 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; Mandelytropeine; MFCD00067305
Molecular Formula	C16H21NO3
Molecular Weight	311.80
Purity	98
Density	1.21 g/cm3
Boiling Point	403.3ºC
Melting Point	100ºC
Application	Homatropine is an orally active muscarinic acetylcholine receptor antagonist that can be used as an anticholinergic drug [1].
HTC	2933990090
MDL Number	MFCD00050613
SMILES	Cl.N1([C@@H]2C[C@H](C[C@H]1CC2)OC(=O)C(O)c3ccccc3)C
InChI	InChI=1S/C4H3ClF4O2/c1-11-2(10)3(6,7)4(5,8)9/h1H3
InChI Key	FRMDDIJBLQNNTC-RDYJJYPNSA-N
NACRES Code	NA.21
UNSPSC	12352200
MSDS	msds/10853_1_87_00_3.pdf
Use of	Homatropine is an orally active muscarinic acetylcholine receptor antagonist and can be used as an anticholinergic agent[1]. Properties Name [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate Synonym More Synonyms Homatropine Biological Activity Description Homatropine is an orally active muscarinic acetylcholine receptor antagonist and can be used as an anticholinergic agent[1]. Related Catalog Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease In Vitro Homatropine (20 μM) alone produces a dose ratio of 259 in atrium from guinea-pigs, and produces a dose ratio of only 95.0 when combined with Hexamethonium Bromide (HY-B0569) in atrium from guinea-pigs[1]. Homatropine has affinities for muscarinic receptors in stomach (pA2 = 7.13) and for those in atria mediating force (pA2 = 7.21) and rate (pA2 = 7.07) responses[2]. Chemical & Physical Properties Molecular Formula C16H21NO3 Exact Mass 275.15200 PSA 49.77000 LogP 1.82630 InChIKey ZTVIKZXZYLEVOL-DGKWVBSXSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1-alpha-H,5-alpha-H-Tropan-3-alpha-ol, mandelate (ester) CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C16-H21-N-O3 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T56 A ANTJ A1 GOVYQR HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 1,156,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2035763 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2035763 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FRXXBL French Demande Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #2035763 * NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA * NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84350 No. of Facilities: 170 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2582 (estimated) Safety Information HS Code 2933990090 Synthetic Route Total: 1 Page Mandelic acid CAS#:611-71-2 CAS#:120-29-6 Homatropine CAS#:87-00-3 Literature: Journal fuer Praktische Chemie (Leipzig), , vol. <2> 117, p. 147
Tax Rebate	13.0%
Supervision	None. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport Info	Product name: Chinese name Houmatropin English name [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 2-hydroxy-2-phenylacetate Chinese alias mandelyltropine \| 8-methyl-8-azabicyclo[3.2.1]octane-3-ol hydroxy(phenyl)acetate English aliases more

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Homatropine

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