CAS Number76712-82-8
Synonymshistreline; histrelinum; HISTRELIN; MFCD00133494; histrelina; (Des-Gly10,His(Bzl)6,Pro-NHEt9)-LHRH
Molecular FormulaC66H86N18O12
Molecular Weight1323.502
Purity98%
Density1.5±0.1 g/cm3
Boiling Point1800.6ºC at 760 mmHg
AppearanceWhite or almost white freeze-dried powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 76712-82-8 |
| Catalog No. | 2A-9010852 |
| Chinese Name | 组氨瑞林 |
| Synonyms | histreline; histrelinum; HISTRELIN; MFCD00133494; histrelina; (Des-Gly10,His(Bzl)6,Pro-NHEt9)-LHRH |
| Molecular Formula | C66H86N18O12 |
| Molecular Weight | 1323.502 |
| Purity | 98 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 1800.6ºC at 760 mmHg |
| Appearance | White or almost white freeze-dried powder |
| Storage Condition | room temperature, dry |
| Application | Histrelin is a gonadotropin-releasing hormone analogue and a gonadotropin-releasing hormone receptor agonist. Histidine increases serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), an |
| HTC | 2937190090 |
| SMILES | CCNC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(Cc1cn(Cc2ccccc2)cn1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1 |
| InChI | InChI=1S/C66H86N18O12/c1-4-70-64(95)55-17-11-25-84(55)65(96)48(16-10-24-71-66(67)68)76-58(89)49(26-38(2)3)77-62(93)53(30-43-34-83(37-74-43)33-40-12-6-5-7-13-40)81-59(90)50(27-39-18-20-44(86)21-19-39)78-63(94)54(35-85)82-60(91)51(28-41-31-72-46-15-9-8-14-45(41)46)79-61(92)52(29-42-32-69-36-73-42)80-57(88)47-22-23-56(87)75-47/h5-9,12-15,18-21,31-32,34,36-38,47-55,72,85-86H,4,10-11,16-17,22-30,33,35H2,1-3H3,(H,69,73)(H,70,95)(H,75,87)(H,76,89)(H,77,93)(H,78,94)(H,79,92)(H,80,88)(H,81,90)(H,82,91)(H4,67,68,71) |
| InChI Key | HHXHVIJIIXKSOE-QILQGKCVSA-N |
| Use of | Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis[1][2][5]. Properties Articles42 Name histrelin Synonym More Synonyms Histrelin Biological Activity Description Histrelin, a GnRH analogue, is a GnRH Receptor agonist. Histrelin increases serum luteinising hormone (LH), follicle stimulating hormone (FSH) and testosterone levels. Histrelin can be used in the research of prostate cancer, endometriosis[1][2][5]. Related Catalog Signaling Pathways >> GPCR/G Protein >> GNRH Receptor Research Areas >> Cancer GnRH Receptor[1] In Vitro Histrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants[4]. Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system[5]. References [1]. Emma D Deeks, et al. Histrelin: in advanced prostate cancer. Drugs. 2010 Mar 26;70(5):623-30. [2]. P E Cohen, et al. Colony-stimulating factor-1 plays a major role in the development of reproductive function in male mice. Mol Endocrinol. 1997 Oct;11(11):1636-50. [3]. D W Hahn, et al. Development of an animal model for quantitatively evaluating effects of drugs on endometriosis. Fertil Steril. 1985 Sep;44(3):410-5. [4]. E Boczek-Leszczyk, et al. Vasopressin release from the rat hypothalamo-neurohypophysial system: effects of gonadotrophin-releasing hormone (GnRH), its analogues and melatonin. J Physiol Pharmacol. 2010 Aug;61(4):459-66. [5]. Marlena Juszczak, et al. Hypothalamic gonadotropin-releasing hormone receptor activation stimulates oxytocin release from the rat hypothalamo-neurohypophysial system while melatonin inhibits this process. Brain Res Bull. 2010 Jan 15;81(1):185-90. Chemical & Physical Properties Molecular Formula C66H86N18O12 Exact Mass 1322.667236 PSA 446.86000 Index of Refraction 1.701 InChIKey HHXHVIJIIXKSOE-QILQGKCVSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Luteinizing hormone releasing factor (pig), 6-(1-(phenylmethyl)-D-histidine)-9-(N-ethyl-L- prolinamide)-10-deglycinamide- CAS REGISTRY NUMBER : 76712-82-8 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C66-H86-N18-O12 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SEX/DURATION : male 2 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Paternal Effects - other effects on male REFERENCE : JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 7,140,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous 4667 ug/kg SEX/DURATION : male 8 week(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) REFERENCE : JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 7,140,1986 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous 2333 ug/kg SEX/DURATION : male 4 week(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) REFERENCE : JOAND3 Journal of Andrology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1980- Volume(issue)/page/year: 7,140,1986 Safety Information Signal Word Danger Hazard Statements H360 Precautionary Statements P201-P308 + P313 Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges Hazard Codes T: Toxic; Risk Phrases R60 RIDADR NONH for all modes of transport WGK Germany 3 RTECS OK6370800 HS Code 2937190090 |
| Transport Info | Product name: (Des-Gly10,His(Bzl)6,Pro-NHEt9)-LHRH |
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