CAS Number28230-32-2
SynonymsHOOBT; EINECS 248-916-1; 3-hydroxybenzo[d]1,2,3-triazin-4-one; 3-hydroxy-3H-benzo[d][1,2,3]triazin-4-one; DHBT; oxohydroxybenzotriazole; 4-oxo-3,4-dihydro-3-hydroxy-1,2,3-benzotriazine; 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one; 3-Hydroxy-4-ketobenzotriazine; 3-Hydroxy-1,2,3-ben zotriazin-4(3H)-one; 3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine; 1,2,3-Benzotriazin-4(3H)-one,3-hydroxy; MFCD00042803; 3,4-dihydro-3-hydroxy-4-keto-1,2,3-benzotriazine; 3-Hydroxy-3,4-dihydro-4-oxo-1,2,3-benzotriazine
Molecular FormulaC7H5N3O2
Molecular Weight163.133
Purity98%
Density1.6±0.1 g/cm3
Boiling Point348.7±25.0 °C at 760 mmHg
Melting Point184-189°C
AppearanceOff-white to yellow solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 28230-32-2 |
| Catalog No. | 2A-9010860 |
| Chinese Name | 3-羟基-1,2,3-苯并三嗪-4(3H)-酮(HOOBt) |
| Synonyms | HOOBT; EINECS 248-916-1; 3-hydroxybenzo[d]1,2,3-triazin-4-one; 3-hydroxy-3H-benzo[d][1,2,3]triazin-4-one; DHBT; oxohydroxybenzotriazole; 4-oxo-3,4-dihydro-3-hydroxy-1,2,3-benzotriazine; 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one; 3-Hydroxy-4-ketobenzotriazine; 3-Hydroxy-1,2,3-ben zotriazin-4(3H)-one; 3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine; 1,2,3-Benzotriazin-4(3H)-one,3-hydroxy; MFCD00042803; 3,4-dihydro-3-hydroxy-4-keto-1,2,3-benzotriazine; 3-Hydroxy-3,4-dihydro-4-oxo-1,2,3-benzotriazine |
| Molecular Formula | C7H5N3O2 |
| Molecular Weight | 163.133 |
| Purity | 98 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 348.7±25.0 °C at 760 mmHg |
| Melting Point | 184-189°C |
| Appearance | Off-white to yellow solid |
| Storage Condition | Sealed, stored at 2ºC -8ºC |
| Application | HODHBt (HOOBt) inhibits the STAT5-SUMO interaction by blocking the SUMOylation of phosphorylated STAT5. HODHBt can be used in research on HIV infection and cancer [1]. |
| HTC | 2933699090 |
| SMILES | O=c1c2ccccc2nnn1O |
| InChI | InChI=1S/C7H5N3O2/c11-7-5-3-1-2-4-6(5)8-9-10(7)12/h1-4,12H |
| InChI Key | HJBLUNHMOKFZQX-UHFFFAOYSA-N |
| Hazard Symbols | 3.0 |
| Bioactivity | HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer[1]. Related Catalog Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> JAK/STAT Signaling >> STAT Target STAT5 In Vitro HODHBt (100 μM; 24 h, and 48 h respectively) increases IL-15-mediated STAT phosphorylation in NK cells and enhances the cytotoxic profile of NK cells[1]. HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL) cytotoxicity of NK cells against HIV-infected cells (K562 cells)[1]. HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL, 6 h) cytotoxicity of NK cells against cancer cell lines (A2780 and U877; OCILy1 and OCILy10)[1]. HODHBt (100 μM; 7 d) results in enhanced memory response upon recall in generation of human CIML NK cells in vitro[1]. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 348.7±25.0 °C at 760 mmHg Melting Point 184-189°C Molecular Formula C7H5N3O2 Molecular Weight 163.133 Flash Point 164.7±23.2 °C Exact Mass 163.038177 PSA 68.01000 LogP 0.43 Vapour Pressure 0.0±0.8 mmHg at 25°C Index of Refraction 1.739 InChIKey HJBLUNHMOKFZQX-UHFFFAOYSA-N SMILES O=c1c2ccccc2nnn1O Storage condition 2-8°C |
| Use of | HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer[1]. Properties Name 3-hydroxy-1,2,3-benzotriazin-4-one Synonym More Synonyms HOOBT Biological Activity Description HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer[1]. Related Catalog Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> JAK/STAT Signaling >> STAT Chemical & Physical Properties Molecular Formula C7H5N3O2 Exact Mass 163.038177 PSA 68.01000 Index of Refraction 1.739 InChIKey HJBLUNHMOKFZQX-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 3379 International Dangerous Regulations for sea transport: 3379 International Dangerous Regulations for air transport: 3379 14.2 United Nations shipping name European Land Transport Dangerous Regulations: DESENSITIZED EXPLOSIVE, LIQUID, N.O.S. (N,N-Dimethylformamide, 3-Hydroxy-1,2,3- benzotriazin-4(3H)-one) IMDG: DESENSITIZED EXPLOSIVE, LIQUID, N.O.S. (N,N-Dimethylformamide, 3-Hydroxy-1,2,3- benzotriazin-4(3H)-one) International air transport hazard regulations: Desensitized explosive, liquid, n.o.s. (N,N-Dimethylformamide, 3-Hydroxy-1,2,3- benzotriazin-4(3H)-one) Passenger aircraft: No transport allowed Cargo aircraft: not allowed to transport 14.3 Transport hazard categories European land transport Dangerous Regulations: 3 International sea transport Dangerous Regulations: 3 International air transport Dangerous Regulations: 3 14.4 Package group European land transport danger code: I International sea transport danger code: I International air transport danger code: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Homatropine hydrobromide | 51-56-9 | 2A-9010854 |
| Homatropine methyl bromide | 80-49-9 | 2A-9010855 |
| Homoeriodictyol | 107657-60-3 | 2A-9010856 |
| Homprenorphine | 16549-56-7 | 2A-9010858 |
| Honeysuckle absolute | 8023-93-6 | 2A-9010859 |
| Hop spike extract | 2A-301944 | 2A-9010861 |
| Horsetail P.E. | 2A-301946 | 2A-9010863 |
| (-)-Huperzine A | 102518-79-6 | 2A-9010864 |
| Hydantoin | 461-72-3 | 2A-9010865 |
| Hydrastine | 118-08-1 | 2A-9010866 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS