CAS Number102518-79-6
Synonyms5-Amino-1,2-dihydro-3H-pyrazol-3-one; (−)-Huperzine A; MFCD01714949; (−)-Selagine; (-)-Huperzine A; 3-Amino-5-pyrazolone; 3-Amino-1H-pyrazol-5-ol; Huperzine A
Molecular FormulaC15H18N2O
Molecular Weight242.32
Purity98.00%
Density1.6±0.1 g/cm3
Boiling Point479.5±25.0 °C at 760 mmHg
Melting Point211-216oC
AppearanceWhite to light white crystal powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 102518-79-6 |
| Catalog No. | 2A-9010864 |
| Chinese Name | (-)-石杉碱甲 |
| Synonyms | 5-Amino-1,2-dihydro-3H-pyrazol-3-one; (−)-Huperzine A; MFCD01714949; (−)-Selagine; (-)-Huperzine A; 3-Amino-5-pyrazolone; 3-Amino-1H-pyrazol-5-ol; Huperzine A |
| Molecular Formula | C15H18N2O |
| Molecular Weight | 242.32 |
| Purity | 98.00 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 479.5±25.0 °C at 760 mmHg |
| Melting Point | 211-216oC |
| Appearance | White to light white crystal powder |
| Storage Condition | Sealed in a cool, dry environment at -20 ºC |
| Application | Huperzine A is an active Lycopodium alkaloid extracted from traditional Chinese herbal medicine. It is a reversible acetylcholinesterase (ACE) inhibitor and is widely used in the treatment of Alzheime |
| HTC | 2933990090 |
| MDL Number | C15H18N2O |
| SMILES | CC=C1C2C=C(C)CC1(N)c1ccc(=O)[nH]c1C2 |
| InChI | InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+ |
| InChI Key | ZRJBHWIHUMBLCN-JRYCNTDSSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/10864_1_102518_79_6.pdf |
| Bioactivity | Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value:Target: AChEHuperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease. Related Catalog Signaling Pathways >> Neuronal Signaling >> AChE Natural Products >> Alkaloid Research Areas >> Neurological Disease References [1]. Burshtein G, Friedman M, Greenberg S, Hoffman A. Transepithelial Transport of a Natural Cholinesterase Inhibitor, Huperzine A, along the Gastrointestinal Tract: the Role of Ionization on Absorption Mechanism. Planta Med. 2013 Jan 23. [2]. Ruan Q, Liu F, Gao Z, et al. The anti-inflamm-aging and hepatoprotective effects of huperzine A in d-galactose-treated rats. Mech Ageing Dev. 2013 Jan 8. pii: S0047-6374(12)00182-0. [3]. Zhang HY. New insights into huperzine A for the treatment of Alzheimer's disease. Acta Pharmacol Sin. 2012 Sep;33(9):1170-5. [4]. Wang J, Zhang HY, Tang XC. Huperzine a improves chronic inflammation and cognitive decline in rats with cerebral hypoperfusion. J Neurosci Res. 2010 Mar;88(4):807-15. doi: 10.1002/jnr.22237. [5]. Park P, Schachter S, Yaksh T. Intrathecal huperzine A increases thermal escape latency and decreases flinching behavior in the formalin test in rats. Neurosci Lett. 2010 Feb 5;470(1):6-9. doi: 10.1016/j.neulet.2009.12.033. Chemical & Physical Properties Density 1.6±0.1 g/cm3 Boiling Point 479.5±25.0 °C at 760 mmHg Melting Point 211-216oC Molecular Formula C15H18N2O Molecular Weight 242.32 Flash Point 243.8±23.2 °C PSA 58.88000 LogP -0.22 Vapour Pressure 0.0±1.2 mmHg at 25°C Index of Refraction 1.741 InChIKey ZRJBHWIHUMBLCN-JRYCNTDSSA-N SMILES CC=C1C2C=C(C)CC1(N)c1ccc(=O)[nH]c1C2 Storage condition −20°C |
| Use of | Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value:Target: AChEHuperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease. Properties Articles48 Name huperzine A Synonym More Synonyms (-)-Huperzine A Biological Activity Description Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD). IC50 value:Target: AChEHuperzine A exhibited protective effects against d-gal-induced hepatotoxicity and inflamm-aging by inhibiting AChE activity and via the activation of the cholinergic anti-inflammatory pathway. The huperzine A mechanism might be involved in the inhibition of DAMPs-mediated NF-κB nuclear localization and activation. Huperzine A is a potential therapeutic agent for Alzheimer's disease. Related Catalog Signaling Pathways >> Neuronal Signaling >> AChE Natural Products >> Alkaloid Research Areas >> Neurological Disease References [1]. Burshtein G, Friedman M, Greenberg S, Hoffman A. Transepithelial Transport of a Natural Cholinesterase Inhibitor, Huperzine A, along the Gastrointestinal Tract: the Role of Ionization on Absorption Mechanism. Planta Med. 2013 Jan 23. [2]. Ruan Q, Liu F, Gao Z, et al. The anti-inflamm-aging and hepatoprotective effects of huperzine A in d-galactose-treated rats. Mech Ageing Dev. 2013 Jan 8. pii: S0047-6374(12)00182-0. [3]. Zhang HY. New insights into huperzine A for the treatment of Alzheimer's disease. Acta Pharmacol Sin. 2012 Sep;33(9):1170-5. Chemical & Physical Properties Molecular Formula C15H18N2O PSA 58.88000 LogP -0.22 Index of Refraction 1.741 InChIKey ZRJBHWIHUMBLCN-JRYCNTDSSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1544 International Maritime Transport Danger Regulations: 1544 International Air Transport Danger Regulations: 1544 14.2 United Nations shipping name European Land Transport Dangerous Regulations: ALKALOIDS, SOLID, N.O.S. ((-)-Huperzine A) IMDG Code: ALKALOIDS, SOLID, N.O.S. ((-)-Huperzine A) IMDG: Alkaloids, solid, n.o.s. ((-)-Huperzine A) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available If applicable, the chemical meets the requirements of the Regulations on the Safety Management of Hazardous Chemicals (adopted by the State Council on January 9, 2002). |
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