CAS Number50-01-1
SynonymsZYZUM &&HCl; Guanidine hydrochloride (1:1); guanidinium chloride; Guanidine, hydrochloride (1:1); Guanidine monohydrochloride; Amino(imino)methanaminium chloride; GdmCl; Guanidine (hydrochloride); guanidine chlorhydrate; hydrochloric acid guanidine; Aminoformamidine hydrochloride,Aminomethanamidine hydrochloride,Guanidinium chloride; Guanidine Hydrochlor; Guanidine chloride; Aminoformamidine hydrochloride; GUANIDIUM CHLORIDE; GUHY; Aminoformamidine hydrochloride,Guanidinium chloride,Guanidium chloride; 1-methylguanidine hydrochloride; Aminomethanamidine hydrochlorid; MFCD00013026; AMINOFORMAMIDINE HCL; Guanidinehydrochloride; Guanidine, monohydrochloride; usafek-749; EINECS 200-002-3; Guanidinhydrochlorid; Guanidine Hydrochloride; Guanidine HCl; guanidinium hydrochloride
Molecular FormulaNH2C(=NH)NH2 · HCl
Molecular Weight95.53
Purity99%
Density1.18 g/mL at 25 °C(lit.)
Boiling Point132.9ºC at 760 mmHg
Melting Point180-185 °C (lit.)
Appearancepowder (or crystals)
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 50-01-1 |
| Catalog No. | 2A-9010804 |
| Chinese Name | 盐酸胍 |
| Synonyms | ZYZUM &&HCl; Guanidine hydrochloride (1:1); guanidinium chloride; Guanidine, hydrochloride (1:1); Guanidine monohydrochloride; Amino(imino)methanaminium chloride; GdmCl; Guanidine (hydrochloride); guanidine chlorhydrate; hydrochloric acid guanidine; Aminoformamidine hydrochloride,Aminomethanamidine hydrochloride,Guanidinium chloride; Guanidine Hydrochlor; Guanidine chloride; Aminoformamidine hydrochloride; GUANIDIUM CHLORIDE; GUHY; Aminoformamidine hydrochloride,Guanidinium chloride,Guanidium chloride; 1-methylguanidine hydrochloride; Aminomethanamidine hydrochlorid; MFCD00013026; AMINOFORMAMIDINE HCL; Guanidinehydrochloride; Guanidine, monohydrochloride; usafek-749; EINECS 200-002-3; Guanidinhydrochlorid; Guanidine Hydrochloride; Guanidine HCl; guanidinium hydrochloride |
| Molecular Formula | NH2C(=NH)NH2 · HCl |
| Molecular Weight | 95.53 |
| Purity | 99 |
| Density | 1.18 g/mL at 25 °C(lit.) |
| Boiling Point | 132.9ºC at 760 mmHg |
| Melting Point | 180-185 °C (lit.) |
| Appearance | powder (or crystals) |
| Water Solubility | 2280 g/L (20 ºC) |
| Storage Condition | Store at RT. |
| Application | Guanidine hydrochloride is a protein metabolite and protein denaturant, formed by the oxidation of guanine. |
| HTC | 2925290090 |
| PubChem ID | 329757653 |
| MDL Number | MFCD00013026 |
| SMILES | Cl[H].NC(N)=N |
| InChI | 1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H |
| InChI Key | PJJJBBJSCAKJQF-UHFFFAOYSA-N |
| Beilstein/REAXYS | 3591990 |
| NACRES Code | NA.23 |
| UNSPSC | 12352107 |
| Hazard Symbols | Transport |
| MSDS | msds/10804_1_50_01_1.pdf |
| Bioactivity | Guanidine HCl, the crystalline compound of strong alkalinity formed by the oxidation of guanine, is a normal product of protein metabolism and a protein denaturant.Target: OthersGuanidine HCl is the most popular protein denaturant. Analysis of unfolding transitions by Guanidine HCl provides several important parameters regarding the mechanism of conformational stability of proteins. Guanidine HCl at low concentrations refolds acid-unfolds apomyoglobin and cytochrome c, stabilizing the molten globule state. Guanidine HCl (> 1 M) causes co-operative unfolding of the molten globule state [1]. Guanidine HCl at millimolar concentrations, is able to causes efficient loss of the normally stable [PSI+] element from yeast cells. 5 mM Guanidine HCl in growth media cures [PSI+] and other prions of yeast. 5 mM Guanidine HCl significantly reduces Hsp104-mediated basal and acquired thermotolerance by 30-fold and 50 fold, respectively. Guanidine HCl also reduces the ability of Hsp104 to restore activity of thermally denatured luciferase [2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Hagihara, Y., et al., Guanidine hydrochloride-induced folding of proteins. J Mol Biol, 1993. 231(2): p. 180-4. [2]. Jung, G. and D.C. Masison, Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol, 2001. 43(1): p. 7-10. Chemical & Physical Properties Density 1.18 g/mL at 25 °C(lit.) Boiling Point 132.9ºC at 760 mmHg Melting Point 180-185 °C(lit.) Molecular Formula CH6ClN3 Molecular Weight 95.531 Exact Mass 95.025024 PSA 75.89000 LogP 1.14090 Index of Refraction n20/D 1.465 InChIKey PJJJBBJSCAKJQF-UHFFFAOYSA-N SMILES Cl.N=C(N)N Storage condition Store at RT. Stability Stable. Hygroscopic. Incompatible with strong oxidizing agents. Water Solubility 2280 g/L (20 ºC) |
| Use of | Properties Articles186 Name Guanidine hydrochloride Synonym More Synonyms Guanidine hydrochloride Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease References [1]. Hagihara, Y., et al., Guanidine hydrochloride-induced folding of proteins. J Mol Biol, 1993. 231(2): p. 180-4. [2]. Jung, G. and D.C. Masison, Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol, 2001. 43(1): p. 7-10. Chemical & Physical Properties Exact Mass 95.025024 PSA 75.89000 LogP 1.14090 InChIKey PJJJBBJSCAKJQF-UHFFFAOYSA-N SMILES Cl.N=C(N)N Storage condition Store at RT. Stability Stable. Hygroscopic. Incompatible with strong oxidizing agents. |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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