CAS Number29110-48-3
SynonymsIntuniv; N (Aminoiminomethyl)-2,6-dichlorobenzeneacetamide; n-carbamimidoyl-2-(2,6-dichlorphenyl)acetamidhydrochlorid; guanfacine hydrochloride; GUANFACINE HCL; MFCD00798230; N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride; GuanfacineHydrochloride; N-carbamimidoyl-2-(2,6-dichlorophényl)acétamide chlorhydrate; BS-100-141; Estulic; Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, hydrochloride (1:1); N-amidino-2-(2,6-dichlorophenyl) acetamide monohydrochloride; N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride (1:1); EINECS 249-443-3; N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide Hydrochloride; N-Amidino-2-(2,6-dichlorophenyl)acetamide Hydrochloride; Guanfacine hydrochloride,[(2,6-Dichlorophenyl)acetyl]guanidinehydrochloride; Tenex; Guanfacine (hydrochlorid
Molecular FormulaC9H10Cl3N3O
Molecular Weight282.55
Purity≥98 (HPLC)%
Melting Point213 °C
Appearancewhite
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 29110-48-3 |
| Catalog No. | 2A-9010803 |
| Chinese Name | 盐酸胍法辛 |
| Synonyms | Intuniv; N (Aminoiminomethyl)-2,6-dichlorobenzeneacetamide; n-carbamimidoyl-2-(2,6-dichlorphenyl)acetamidhydrochlorid; guanfacine hydrochloride; GUANFACINE HCL; MFCD00798230; N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride; GuanfacineHydrochloride; N-carbamimidoyl-2-(2,6-dichlorophényl)acétamide chlorhydrate; BS-100-141; Estulic; Benzeneacetamide, N-(aminoiminomethyl)-2,6-dichloro-, hydrochloride (1:1); N-amidino-2-(2,6-dichlorophenyl) acetamide monohydrochloride; N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide hydrochloride (1:1); EINECS 249-443-3; N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide Hydrochloride; N-Amidino-2-(2,6-dichlorophenyl)acetamide Hydrochloride; Guanfacine hydrochloride,[(2,6-Dichlorophenyl)acetyl]guanidinehydrochloride; Tenex; Guanfacine (hydrochlorid |
| Molecular Formula | C9H10Cl3N3O |
| Molecular Weight | 282.55 |
| Purity | ≥98 (HPLC) |
| Melting Point | 213 °C |
| Appearance | white |
| Water Solubility | H2O: 12 mg/mL at 60 °C, soluble |
| Storage Condition | Keep the receptacle sealed, stored in a cool, dry |
| Packaging | III |
| Application | Guanfacine hydrochloride is an α2A adrenoceptor agonist with a Kd of 31 nM and has antihypertensive activity. |
| PubChem ID | 24278452 |
| MDL Number | MFCD00798230 |
| SMILES | Cl.NC(=N)NC(=O)Cc1c(Cl)cccc1Cl |
| InChI | 1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H |
| InChI Key | DGFYECXYGUIODH-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/10803_1_29110_48_3.pdf |
| Bioactivity | Guanfacine Hcl, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors. IC50 Value: 31 nM(Kd)Target: Adrenergic ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone. From Wikipedia Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease References [1]. Intengan HD, Smyth DD. Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance. J Pharmacol Exp Ther. 1997 Apr;281(1):48-53. [2]. Uhlén S, Wikberg JE. Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound. Eur J Pharmacol. 1991 Sep 17;202(2):235-43. [3]. Board AW, Perry VP, Shepperson BE, A postmarketing evaluation of guanfacine hydrochloride in mild to moderate hypertension. Clin Ther. 1988;10(6):761-75. [4]. Guanfacine Chemical & Physical Properties Melting Point 213 °C Molecular Formula C9H10Cl3N3O Molecular Weight 282.554 Exact Mass 280.988953 PSA 78.97000 LogP 3.53850 Appearance of Characters white InChIKey DGFYECXYGUIODH-UHFFFAOYSA-N SMILES Cl.NC(N)=NC(=O)Cc1c(Cl)cccc1Cl Storage condition Store at RT Water Solubility H2O: 12 mg/mL at 60 °C, soluble |
| Use of | Guanfacine Hcl, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors. IC50 Value: 31 nM(Kd)Target: Adrenergic ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone. From Wikipedia Properties Articles30 Name Guanfacine Hydrochloride Synonym More Synonyms guanfacine hydrochloride Biological Activity Description Guanfacine Hcl, an anti-hypertensive agent, is a selective α2A-adrenoceptor agonist with Kd of 31 nM and displays 60-fold selectivity over α2B-adrenoceptors. IC50 Value: 31 nM(Kd)Target: Adrenergic ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone. From Wikipedia Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease References [1]. Intengan HD, Smyth DD. Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance. J Pharmacol Exp Ther. 1997 Apr;281(1):48-53. [2]. Uhlén S, Wikberg JE. Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound. Eur J Pharmacol. 1991 Sep 17;202(2):235-43. [3]. Board AW, Perry VP, Shepperson BE, A postmarketing evaluation of guanfacine hydrochloride in mild to moderate hypertension. Clin Ther. 1988;10(6):761-75. [4]. Guanfacine Chemical & Physical Properties Exact Mass 280.988953 PSA 78.97000 LogP 3.53850 Appearance of Characters white InChIKey DGFYECXYGUIODH-UHFFFAOYSA-N Storage condition Store at RT |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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