CAS Number29110-47-2
SynonymsIntuniv; Guanfacine; Guanfacina [INN-Spanish]; [(2,6-Dichlorophenyl)acetyl]guanidine; Guanfacine [INN:BAN]; N-amidino-2-(2,6-dichlorophenyl)acetamide; N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide; Estulic; Lon798; Guanfacina; N-(aminoiminomethyl)-2,6-dichlorobenzeneacetamide; Guanfacinum; Guanfacinum [INN-Latin]; BS 100-141; Tenex
Molecular FormulaC9H9Cl2N3O
Molecular Weight282.55
Purity98.00%
Density1.5±0.1 g/cm3
Boiling Point424.9ºC at 760 mmHg
Melting Point227-230?C
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 29110-47-2 |
| Catalog No. | 2A-9010802 |
| Chinese Name | 氯酰胍 |
| Synonyms | Intuniv; Guanfacine; Guanfacina [INN-Spanish]; [(2,6-Dichlorophenyl)acetyl]guanidine; Guanfacine [INN:BAN]; N-amidino-2-(2,6-dichlorophenyl)acetamide; N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide; Estulic; Lon798; Guanfacina; N-(aminoiminomethyl)-2,6-dichlorobenzeneacetamide; Guanfacinum; Guanfacinum [INN-Latin]; BS 100-141; Tenex |
| Molecular Formula | C9H9Cl2N3O |
| Molecular Weight | 282.55 |
| Purity | 98.00 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 424.9ºC at 760 mmHg |
| Melting Point | 227-230?C |
| Storage Condition | Refrigerator |
| Application | Guanfacine is an α2A adrenoceptor agonist with a Kd of 31 nM and has antihypertensive activity. |
| HTC | 2925290090 |
| PubChem ID | 329749977 |
| MDL Number | MFCD00798230 |
| SMILES | Cl.NC(=N)NC(=O)Cc1c(Cl)cccc1Cl |
| InChI | 1S/C9H9Cl2N3O.ClH/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13;/h1-3H,4H2,(H4,12,13,14,15);1H |
| InChI Key | DGFYECXYGUIODH-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10802_1_29110_47_2.pdf |
| Use of | Guanfacine is a selective α2A receptor agonist.Target: α2A ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone [1, 2]. Properties Name N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide Synonym More Synonyms Guanfacine Biological Activity Description Guanfacine is a selective α2A receptor agonist.Target: α2A ReceptorGuanfacine is a sympatholytic. It is a selective α2A receptor agonist. These receptors are concentrated heavily in the prefrontal cortex and the locus coeruleus, with the potential to improve attention resulting from interaction with receptors in the former. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α2A norepinephrine autoreceptors, which results in reduced peripheral sympathetic outflow and thus a reduction in peripheral sympathetic tone [1, 2]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease References [1]. Kolar, D., et al., Treatment of adults with attention-deficit/hyperactivity disorder. Neuropsychiatr Dis Treat, 2008. 4(2): p. 389-403. [2]. Zwieten, P.v., M. Thoolen, and P. Timmermans, The pharmacology of centrally acting antihypertensive drugs. British journal of clinical pharmacology, 1983. 15(Supplement s4): p. 455S-462S. Chemical & Physical Properties Exact Mass 245.012268 PSA 78.97000 Index of Refraction 1.635 InChIKey INJOMKTZOLKMBF-UHFFFAOYSA-N Storage condition Refrigerator Safety Information HS Code 2925290090 Synthetic Route Total: 1 Page 2,6-Dichlorophe... CAS#:6575-24-2 METHYL THIOPSEU... CAS#:14527-26-5 Guanfacine CAS#:29110-47-2 Literature: Dodd, Dharmpal S.; Zhao, Yufen Tetrahedron Letters, 2001 , vol. 42, # 7 p. 1259 - 1262 2-(2,6-Dichloro... CAS#:3215-64-3 Guanfacine CAS#:29110-47-2 Literature: Bream; Lauener; Picard; Scholtysik; White Arzneimittel-Forschung/Drug Research, 1975 , vol. 25, # 10 p. 1477 - 1482 Methyl chloro(2... CAS#:54551-83-6 CAS#:113-00-8 Guanfacine CAS#:29110-47-2 Literature: Bream; Lauener; Picard; Scholtysik; White Arzneimittel-Forschung/Drug Research, 1975 , vol. 25, # 10 p. 1477 - 1482 Precursor & DownStream Precursor 5 CAS#:6575-24-2 2,6-Dichlorophe... CAS#:14527-26-5 METHYL THIOPSEU... CAS#:3215-64-3 2-(2,6-Dichloro... CAS#:54551-83-6 Methyl chloro(2... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Product name: Summary 2925290090 other imines and their derivatives; salts thereof. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff: 6.5%. General tariff:30.0% |
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