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Guanethidine sulfate structure, CAS 645-43-2

Guanethidine sulfate

CAS Number645-43-2

Synonyms1-[2-(Azocan-1-yl)ethyl]guanidine sulfate (1:1); EINECS 211-442-0; Iporal; Guanethidine bisulfate; 1-[2-(1-Azocanyl)ethyl]guanidine sulfate; Guanidine, N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-, sulfate (1:1); 2-[2-(azocan-1-yl)ethyl]guanidine,sulfuric acid; Sanotensin; MFCD00035403; 1-[2-(1-Azocanyl)ethyl]guanidine sulfate (1:1); 1-[2-(Azocan-1-yl)ethyl]guanidine sulfate; Guanethidine Sulfate; Ismelin sulfate; UNII-5UBY8Y002G; Guanetidin sulfate; Guanethidine monosulfate; 1-[2-(Azocan-1-yl)ethyl]guanidinsulfat; N-(2-Guanidino ethyl)heptamethylenimine sulfate; 1-(2-azocan-1-ylethyl)guanidine sulfate; Ismelin; guanethidine sulphate

Molecular FormulaC10H22N4 · H2SO4

Molecular Weight296.39

Purity98%

Density

Boiling Point345.6ºC at 760 mmHg

Melting Point

Flash Point

Appearance

EINECS

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Symbol

Signal Word

Cat. No.: 2A-9010801 Purity: 98%
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Quality Control of [ 645-43-2 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number645-43-2
Catalog No.2A-9010801
Chinese Name胍乙啶单硫酸盐
Synonyms1-[2-(Azocan-1-yl)ethyl]guanidine sulfate (1:1); EINECS 211-442-0; Iporal; Guanethidine bisulfate; 1-[2-(1-Azocanyl)ethyl]guanidine sulfate; Guanidine, N-[2-(hexahydro-1(2H)-azocinyl)ethyl]-, sulfate (1:1); 2-[2-(azocan-1-yl)ethyl]guanidine,sulfuric acid; Sanotensin; MFCD00035403; 1-[2-(1-Azocanyl)ethyl]guanidine sulfate (1:1); 1-[2-(Azocan-1-yl)ethyl]guanidine sulfate; Guanethidine Sulfate; Ismelin sulfate; UNII-5UBY8Y002G; Guanetidin sulfate; Guanethidine monosulfate; 1-[2-(Azocan-1-yl)ethyl]guanidinsulfat; N-(2-Guanidino ethyl)heptamethylenimine sulfate; 1-(2-azocan-1-ylethyl)guanidine sulfate; Ismelin; guanethidine sulphate
Molecular FormulaC10H22N4 · H2SO4
Molecular Weight296.39
Purity98
Boiling Point345.6ºC at 760 mmHg
Storage Condition-20°C
ApplicationGuanethidine is an antihypertensive drug that reduces the release of catecholamines.
HTC2933990090
PubChem ID329749973
MDL NumberMFCD00035403
SMILESOS(O)(=O)=O.NC(=N)NCCN1CCCCCCC1
InChI1S/C10H22N4.H2O4S/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h1-9H2,(H4,11,12,13);(H2,1,2,3,4)
InChI KeyYUFWAVFNITUSHI-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/10801_1_645_43_2.pdf
Use ofGuanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.IC50 value:Target: Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine.It may also inhibit the release of granules by decreasing norepinephrine. Properties Name guanethidine monosulfate Synonym More Synonyms Guanethidine sulfate Biological Activity Description Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine.IC50 value:Target: Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine.It may also inhibit the release of granules by decreasing norepinephrine. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Fabiani ME, et al. Inhibition of sympathetic noradrenergic transmission by guanabenz and guanethidine in rat isolated mesenteric artery: involvement of neuronal potassium channels. Pharmacol Res. 1996 Mar;33(3):171-80. [2]. Joyce PI, et al. The effect of guanethidine and local anesthetics on the electrically stimulated mouse vas deferens. Anesth Analg. 2002 Nov;95(5):1339-43. Chemical & Physical Properties Molecular Formula C10H24N4O4S Exact Mass 296.151825 PSA 148.12000 LogP 2.29240 InChIKey YUFWAVFNITUSHI-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C10-H22-N4.H2-O4-S MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T8NTJ A2MYZUM &S-O4 HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : Standard Draize test ROUTE OF EXPOSURE : Administration into the eye SPECIES OBSERVED : REFERENCE : BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 4,592,1967 ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) REFERENCE : ARPMAS Archiv der Pharmazie (Weinheim, Germany) (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.51-261, 1835-1923; V.305- 1972- Volume(issue)/page/year: 321,57,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 18500 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 111,353,1972 Safety Information Signal Word Warning Hazard Statements H302 Precautionary Statements P301 + P312 + P330 Hazard Codes Xn: Harmful; Risk Phrases R22 Safety Phrases S25-S36 RIDADR NONH for all modes of transport RTECS MF3150000 HS Code 2933990090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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