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Fluorometholone structure, CAS 426-13-1

Fluorometholone

CAS Number426-13-1

SynonymsEINECS 207-041-5; Fluoromethalone; 21-Desoxy-6a-methyl-9a-fluoroprednisolone; (6α,11β)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione; Fluormetholon; fluorometholone; FLAREX; Efflumidex; 9-Fluoro-11,17-Dihydroxy-6-Methylpregna-1,4-Diene-3,20-Dione; 21-Desoxy-9a-fluoro-6a-methylprednisolone; Loticort; MFCD00056461; (6a,11b)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione; Fluaton; Ursnon; Fluoro methalone

Molecular FormulaC22H29FO4

Molecular Weight376.46

Purity98%

Density1.3±0.1 g/cm3

Boiling Point527.1±50.0 °C at 760 mmHg

Melting Point292 - 303ºC

Flash Point

AppearanceSolid;White to Orange to Green powder to crystal

EINECS

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Cat. No.: 2A-0201796 Purity: 98%
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Quality Control of [ 426-13-1 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number426-13-1
Catalog No.2A-0201796
Chinese Name氟米龙
SynonymsEINECS 207-041-5; Fluoromethalone; 21-Desoxy-6a-methyl-9a-fluoroprednisolone; (6α,11β)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione; Fluormetholon; fluorometholone; FLAREX; Efflumidex; 9-Fluoro-11,17-Dihydroxy-6-Methylpregna-1,4-Diene-3,20-Dione; 21-Desoxy-9a-fluoro-6a-methylprednisolone; Loticort; MFCD00056461; (6a,11b)-9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione; Fluaton; Ursnon; Fluoro methalone
Molecular FormulaC22H29FO4
Molecular Weight376.46
Purity98
Density1.3±0.1 g/cm3
Boiling Point527.1±50.0 °C at 760 mmHg
Melting Point292 - 303ºC
AppearanceSolid;White to Orange to Green powder to crystal
Storage Conditionavoid light
ApplicationFluorometholone is a synthetic glucocorticoid that acts as a glucocorticoid receptor agonist and has anti-inflammatory and anti-allergic properties. Fluorometholone is used to relieve dry eye symptoms
HTC2937229000
PubChem ID329749869
MDL NumberMFCD00056461
SMILESC[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(C)=O)[C@@]3(C)C[C@H](O)[C@]2(F)[C@@]4(C)C=CC(=O)C=C14
InChI1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1
InChI KeyFAOZLTXFLGPHNG-KNAQIMQKSA-N
NACRES CodeNA.24
UNSPSC41116107
MSDSmsds/10570_1_426_13_1.pdf
BioactivityFluorometholone, a synthetic glucocorticoid, is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic properties. Fluorometholone can be used in the management of dry eye[1]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor Target glucocorticoid receptor[1] In Vitro Fluorometholone (25-100 nM; 12 hours, 24 hours) increases the gene expression of MUC1, MUC4, MUC16 and MUC19 in the conjunctival and corneal epithelial cells through activation of glucocorticoid receptors[1]. References [1]. Jonathan Taniguchi, et al. Fluorometholone Modulates Gene Expression of Ocular Surface Mucins. Acta Ophthalmol. 2019 Dec;97(8):e1082-e1088. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 527.1±50.0 °C at 760 mmHg Melting Point 292 - 303ºC Molecular Formula C22H29FO4 Molecular Weight 376.462 Flash Point 272.6±30.1 °C Exact Mass 376.204987 PSA 74.60000 LogP 2.02 Vapour Pressure 0.0±3.1 mmHg at 25°C Index of Refraction 1.574 InChIKey FAOZLTXFLGPHNG-KNAQIMQKSA-N SMILES CC(=O)C1(O)CCC2C3CC(C)C4=CC(=O)C=CC4(C)C3(F)C(O)CC21C
Use ofFluorometholone, a synthetic glucocorticoid, is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic properties. Fluorometholone can be used in the management of dry eye[1]. Properties Articles45 Name fluorometholone Synonym More Synonyms fluoromethalone Biological Activity Description Fluorometholone, a synthetic glucocorticoid, is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic properties. Fluorometholone can be used in the management of dry eye[1]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor glucocorticoid receptor[1] In Vitro Fluorometholone (25-100 nM; 12 hours, 24 hours) increases the gene expression of MUC1, MUC4, MUC16 and MUC19 in the conjunctival and corneal epithelial cells through activation of glucocorticoid receptors[1]. References [1]. Jonathan Taniguchi, et al. Fluorometholone Modulates Gene Expression of Ocular Surface Mucins. Acta Ophthalmol. 2019 Dec;97(8):e1082-e1088. Chemical & Physical Properties Molecular Formula C22H29FO4 Exact Mass 376.204987 PSA 74.60000 Index of Refraction 1.574 InChIKey FAOZLTXFLGPHNG-KNAQIMQKSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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