CAS Number152-97-6
SynonymsFLUORCORTOLONE; SH-742; 6a-Fluoro-16a-methyl-1-dehydrocorticosterone; Fluorocortolone; Fluocortolon; flucortolone; 6a-Fluoro-16a-methyl-D1,4-pregnadiene-11b,21-diol-3,20-dione; EINECS 205-811-5; (6α,11β,16α)-6-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; methylfluorodehydrocorticosterone; Fluocortolone
Molecular FormulaC22H29FO4
Molecular Weight460.58
Purity97%
Density1.3±0.1 g/cm3
Boiling Point537.4±50.0 °C at 760 mmHg
Melting Point113-116ºC
AppearanceLight yellow solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 152-97-6 |
| Catalog No. | 2A-9010565 |
| Chinese Name | 氟可龙 |
| Synonyms | FLUORCORTOLONE; SH-742; 6a-Fluoro-16a-methyl-1-dehydrocorticosterone; Fluorocortolone; Fluocortolon; flucortolone; 6a-Fluoro-16a-methyl-D1,4-pregnadiene-11b,21-diol-3,20-dione; EINECS 205-811-5; (6α,11β,16α)-6-Fluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione; methylfluorodehydrocorticosterone; Fluocortolone |
| Molecular Formula | C22H29FO4 |
| Molecular Weight | 460.58 |
| Purity | 97 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 537.4±50.0 °C at 760 mmHg |
| Melting Point | 113-116ºC |
| Appearance | Light yellow solid |
| Storage Condition | 2~8°C |
| Application | Fluocortolone is an orally available anti-inflammatory agent that effectively reduces plasma fibrinogen levels. Fluocortolone inhibits Mycobacterium butyricum-induced foot edema in a rat model of adju |
| HTC | 2942000000 |
| SMILES | F[C@H]1C[C@@H]2[C@@H]([C@@]4(C1=CC(=O)C=C4)C)[C@H](C[C@]3([C@H]2C[C@H]([C@@H]3C(=O)COC(=O)C(C)(C)C)C)C)O |
| InChI | 1S/C27H37FO5/c1-14-9-17-16-11-19(28)18-10-15(29)7-8-26(18,5)23(16)20(30)12-27(17,6)22(14)21(31)13-33-24(32)25(2,3)4/h7-8,10,14,16-17,19-20,22-23,30H,9,11-13H2,1-6H3/t14-,16+,17+,19+,20+,22-,23-,26+,27+/m1/s1 |
| InChI Key | XZBJVIQXJHGUBE-HZMVJJPJSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/10565_1_152_97_6.pdf |
| Use of | Properties Name Fluocortolone Synonym More Synonyms Fluocortolone Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [1]. Bhargava A S. Effect of anti-inflammatory agents on adjuvant-induced edema modified for primary test[J]. Pharmacological Research Communications, et al. Effect of anti-inflammatory agents on adjuvant-induced edema modified for primary test[J]. Pharmacological Research Communications, 1971, 3(1): 83-91. . Chemical & Physical Properties Molecular Formula C22H29FO4 Exact Mass 376.204987 PSA 74.60000 Index of Refraction 1.572 InChIKey GAKMQHDJQHZUTJ-ULHLPKEOSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,21-dihydroxy-16-alpha-methyl- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C22-H29-F-O4 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetal death REFERENCE : YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 12 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SEX/DURATION : female 13 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 9,1623,1976 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Administration onto the skin 2500 ug/kg SEX/DURATION : female 6-15 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) REFERENCE : AMBED4 AMI-Berichte. (Berlin, Fed. Rep. Ger.) No. 1-2, 1978-82. Volume(issue)/page/year: (1),127,1988 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SEX/DURATION : female 7-18 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue) REFERENCE : YKRYAH Yakubutsu Ryoho. Medicinal Treatment. (Tokyo, Japan) V.1-14, 1968-81. Suspended. Volume(issue)/page/year: 10,151,1977 Safety Information Hazard Codes Xn HS Code 2942000000 |
| Transport Info | Product name: Fluocoronide |
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