CAS Number30484-77-6
SynonymsGradient; Mondus; Sibelium; Fluxarten; Issium; Flugeral; Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride (1:2); Flunarizine dihydrochloride; EINECS 250-216-6; 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine dihydrochloride; 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride; 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine dihydrochloride; Flunagen; Dinaplex; MFCD00058198; Flunarizine 2HCl; Flunarl; Flunarizine HCl; Flunarizine (dihydrochloride)
Molecular FormulaC26H28Cl2F2N2
Molecular Weight477.42
Purity≥98 (TLC)%
Boiling Point511.3ºC at 760 mmHg
Melting Point204-210ºC
AppearanceWhite crystalline powder, odorless
EINECS250-216-6
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 30484-77-6 |
| Catalog No. | 2A-9010562 |
| Chinese Name | 盐酸氟桂利嗪 |
| Synonyms | Gradient; Mondus; Sibelium; Fluxarten; Issium; Flugeral; Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-, hydrochloride (1:2); Flunarizine dihydrochloride; EINECS 250-216-6; 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine dihydrochloride; 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride; 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine dihydrochloride; Flunagen; Dinaplex; MFCD00058198; Flunarizine 2HCl; Flunarl; Flunarizine HCl; Flunarizine (dihydrochloride) |
| Molecular Formula | C26H28Cl2F2N2 |
| Molecular Weight | 477.42 |
| Purity | ≥98 (TLC) |
| Boiling Point | 511.3ºC at 760 mmHg |
| Melting Point | 204-210ºC |
| Appearance | White crystalline powder, odorless |
| Water Solubility | chloroform/methanol (9:1): 50 mg/mL, clear, colorl |
| Storage Condition | Sealed, stored at 2ºC -8ºC |
| Application | Flunarizine is a calcium channel blocker. |
| EINECS | 250-216-6 |
| HTC | 2933599090 |
| PubChem ID | 24277835 |
| MDL Number | MFCD00058198 |
| SMILES | Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4 |
| InChI | 1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;; |
| InChI Key | RXKMOPXNWTYEHI-RDRKJGRWSA-N |
| Beilstein/REAXYS | 4284243 |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/10562_1_30484_77_6.pdf |
| Bioactivity | Flunarizine is a selective calcium entry blocker.Target: Calcium ChannelFlunarizine is a drug classified as a calcium channel blocker. Flunarizine is a non-selective calcium entry blocker with other actions including histamine H1 receptor blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia, as well as being effective in rapid onset dystonia-parkinsonism (RDP). From Wikipedia. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease References [1]. http://en.wikipedia.org/wiki/Flunarizine Chemical & Physical Properties Boiling Point 511.3ºC at 760 mmHg Melting Point 204-210ºC Molecular Formula C26H28Cl2F2N2 Molecular Weight 477.417 Flash Point 263ºC Exact Mass 476.159760 PSA 6.48000 LogP 6.86500 Storage condition 2-8°C Water Solubility chloroform/methanol (9:1): 50 mg/mL, clear, colorless |
| Use of | Flunarizine is a selective calcium entry blocker.Target: Calcium ChannelFlunarizine is a drug classified as a calcium channel blocker. Flunarizine is a non-selective calcium entry blocker with other actions including histamine H1 receptor blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia, as well as being effective in rapid onset dystonia-parkinsonism (RDP). From Wikipedia. Properties Articles30 Name Flunarizine Dihydrochloride Synonym More Synonyms Flunarizine 2HCl Biological Activity Description Flunarizine is a selective calcium entry blocker.Target: Calcium ChannelFlunarizine is a drug classified as a calcium channel blocker. Flunarizine is a non-selective calcium entry blocker with other actions including histamine H1 receptor blocking activity. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia, as well as being effective in rapid onset dystonia-parkinsonism (RDP). From Wikipedia. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease References [1]. http://en.wikipedia.org/wiki/Flunarizine Chemical & Physical Properties Exact Mass 476.159760 PSA 6.48000 LogP 6.86500 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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