CAS Number5104-49-4
Synonymsfroben; R-Flurbiprofen; R-(-)-Flurbiprofen; (2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid; 2-(2-Fluorobiphenyl-4-yl)propionic Acid; (-)-Flurbiprofen; (R)-Flurbiprofen; ANSAID; EINECS 225-827-6; (2R)-2-(2-Fluoro-1,1'-biphenyl-4-yl)propanoic acid; Cebutid; Stayban; fp70; (R)-2-Flubiprofen; MFCD00079303; ANSIDE; (R)-(−)-2-Fluoro-α-methyl-4-biphenylacetic acid; (2R)-2-(2-Fluoro-4-biphenylyl)propanoic acid; (R)-2-Flurbiprofen; Zepolas; Adfeed; Antadys; Flurbiprofen
Molecular FormulaC6H5C6H3(F)CH(CH3)CO2H
Molecular Weight244.26
Purity98%
Density1.2±0.1 g/cm3
Boiling Point376.2±30.0 °C at 760 mmHg
Melting Point110-112 °C (lit.)
AppearanceWhite to off-white crystalline solid
EINECS225-827-6
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5104-49-4 |
| Catalog No. | 2A-9010580 |
| Chinese Name | 氟比洛芬 |
| Synonyms | froben; R-Flurbiprofen; R-(-)-Flurbiprofen; (2R)-2-(2-fluorobiphenyl-4-yl)propanoic acid; 2-(2-Fluorobiphenyl-4-yl)propionic Acid; (-)-Flurbiprofen; (R)-Flurbiprofen; ANSAID; EINECS 225-827-6; (2R)-2-(2-Fluoro-1,1'-biphenyl-4-yl)propanoic acid; Cebutid; Stayban; fp70; (R)-2-Flubiprofen; MFCD00079303; ANSIDE; (R)-(−)-2-Fluoro-α-methyl-4-biphenylacetic acid; (2R)-2-(2-Fluoro-4-biphenylyl)propanoic acid; (R)-2-Flurbiprofen; Zepolas; Adfeed; Antadys; Flurbiprofen |
| Molecular Formula | C6H5C6H3(F)CH(CH3)CO2H |
| Molecular Weight | 244.26 |
| Purity | 98 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 376.2±30.0 °C at 760 mmHg |
| Melting Point | 110-112 °C (lit.) |
| Appearance | White to off-white crystalline solid |
| Water Solubility | Water solubility: slightly soluble; soluble in: me |
| Storage Condition | Keep away from light, cool and dry place, sealed a |
| Packaging | III |
| Application | Flurbiprofen is a non-steroidal anti-inflammatory compound that has antipyretic and analgesic effects. |
| EINECS | 225-827-6 |
| HTC | 2916399090 |
| PubChem ID | 329823420 |
| MDL Number | MFCD00079303 |
| SMILES | CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2 |
| InChI | 1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18) |
| InChI Key | SYTBZMRGLBWNTM-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/10580_1_5104_49_4.pdf |
| Bioactivity | Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.Target: PGE synthaseFlurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen. Flurbiprofen may have unique pharmacological properties that reduce the accumulation of unfolded proteins and may represent a new class of drug for the fundamental treatment of obesity [1]. Flurbiprofen and its enantiomers selectively lower Aβ42 levels in broken cell γ-secretase assays, indicating that these compounds directly target the γ-secretase complex that generates Aβ from APP. Of the compounds tested, meclofenamic acid, racemic flurbiprofen, and the purified R and S enantiomers of flurbiprofen lowered Aβ42 levels to the greatest extent [2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> PGE synthase Research Areas >> Inflammation/Immunology References [1]. Hosoi, T., et al., Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med, 2014. [2]. Eriksen, J.L., et al., NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest, 2003. 112(3): p. 440-9. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 376.2±30.0 °C at 760 mmHg Melting Point 110-112 °C(lit.) Molecular Formula C15H13FO2 Molecular Weight 244.261 Flash Point 181.3±24.6 °C Exact Mass 244.089951 PSA 37.30000 LogP 4.11 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.568 InChIKey SYTBZMRGLBWNTM-UHFFFAOYSA-N SMILES CC(C(=O)O)c1ccc(-c2ccccc2)c(F)c1 Storage condition Store at RT |
| Use of | Properties Articles27 Name flurbiprofen Synonym More Synonyms Flurbiprofen Biological Activity Related Catalog Signaling Pathways >> Immunology/Inflammation >> PGE synthase Research Areas >> Inflammation/Immunology References [1]. Hosoi, T., et al., Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress. EMBO Mol Med, 2014. [2]. Eriksen, J.L., et al., NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest, 2003. 112(3): p. 440-9. Chemical & Physical Properties Molecular Formula C15H13FO2 Exact Mass 244.089951 PSA 37.30000 Index of Refraction 1.568 InChIKey SYTBZMRGLBWNTM-UHFFFAOYSA-N Storage condition Store at RT |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Flurbiprofen) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Flurbiprofen) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Flurbiprofen) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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