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Flutamide structure, CAS 13311-84-7

Flutamide

CAS Number13311-84-7

Synonyms2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; 4'-Nitro-3'-(trifluoromethyl)isobutyranilide; MFCD00072009; Eulexin; FXFFR BNW EMVY1&1; Flutamidum; 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide; Drogenil; Niftholide; Flutamide; NFBA; 4'-nitro-3'-trifluoromethylisobutyranilide; 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide; Niftolide; niftolid; 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide,Flutamide; Flutamin; EINECS 236-341-9; Flutamida

Molecular FormulaC11H11F3N2O3

Molecular Weight276.21

Purity98%

Density1.4±0.1 g/cm3

Boiling Point400.3±45.0 °C at 760 mmHg

Melting Point112 °C

Flash Point

AppearanceLight yellow solid

EINECS236-341-9

MSDSChineseEnglish

Symbol

Signal Word

Cat. No.: 2A-9010586 Purity: 98%
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Quality Control of [ 13311-84-7 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number13311-84-7
Catalog No.2A-9010586
Chinese Name氟他胺
Synonyms2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide; 4'-Nitro-3'-(trifluoromethyl)isobutyranilide; MFCD00072009; Eulexin; FXFFR BNW EMVY1&1; Flutamidum; 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide; Drogenil; Niftholide; Flutamide; NFBA; 4'-nitro-3'-trifluoromethylisobutyranilide; 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide; Niftolide; niftolid; 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide,Flutamide; Flutamin; EINECS 236-341-9; Flutamida
Molecular FormulaC11H11F3N2O3
Molecular Weight276.21
Purity98
Density1.4±0.1 g/cm3
Boiling Point400.3±45.0 °C at 760 mmHg
Melting Point112 °C
AppearanceLight yellow solid
Water SolubilityWater solubility: insoluble; easily soluble in: me
Storage ConditionStore at RT
ApplicationFlutamide is an anti-androgen compound that can bind to androgen receptors together with its active metabolite. Its Ki is 55 nM and can act on prostate cancer.
EINECS236-341-9
HTC2924299090
PubChem ID24278446
MDL NumberMFCD00072009
SMILESCC(C)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O
InChI1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)
InChI KeyMKXKFYHWDHIYRV-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC51111800
MSDSmsds/10586_1_13311_84_7.pdf
BioactivityFlutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.Target: androgen receptor in vitro: Flutamide (Eulexin) is an antiandrogen drug. Flutamide-OH, the active metabolite of flutamide, directly binds at rat anterior pituitary androgen receptor with Ki values of 55 nM [1]. lutamide does not affect the proliferation of an androgen-sensitive clone of the mouse mammary carcinoma Shionogi SC-l 15 cells in culture, shows only antiandrogenic effect, but not androgenic effect [2]. Flutamide provides treatment for prostate cancer when used along with leuprolide [3].in vivo: Flutamide causes a markedly reduction in rat ventral prostate weight from 319 mg to 245 mg. A combination of flutamide and LHRH agonist induces an additive effect with a decrease in prostate weight to 101 mg, and an marked drop in prostatic ODC activity [4]. Related Catalog Signaling Pathways >> Others >> Androgen Receptor Research Areas >> Cancer References [1]. Simard J, et al. Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Mol Cell Endocrinol. 1986 Mar;44(3):261-70. [2]. Luthy IA, et al. Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture. J Steroid Biochem. 1988 Nov;31(5):845-52. [3]. Crawford ED, et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med. 1989 Aug 17;321(7):419-24. [4]. Marchetti B, et al. Characteristics of flutamide action on prostatic and testicular functions in the rat. J Steroid Biochem. 1988 Jun;29(6):691-8. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 400.3±45.0 °C at 760 mmHg Melting Point 112 °C Molecular Formula C11H11F3N2O3 Molecular Weight 276.212 Flash Point 195.9±28.7 °C Exact Mass 276.072174 PSA 74.92000 LogP 3.72 Vapour Pressure 0.0±0.9 mmHg at 25°C Index of Refraction 1.521 InChIKey MKXKFYHWDHIYRV-UHFFFAOYSA-N SMILES CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(C(F)(F)F)c1 Storage condition Store at RT
Use ofProperties Articles107 Name flutamide Synonym More Synonyms Flutamide Biological Activity Related Catalog Signaling Pathways >> Others >> Androgen Receptor Research Areas >> Cancer References [1]. Simard J, et al. Characteristics of interaction of the antiandrogen flutamide with the androgen receptor in various target tissues. Mol Cell Endocrinol. 1986 Mar;44(3):261-70. [2]. Luthy IA, et al. Androgenic activity of synthetic progestins and spironolactone in androgen-sensitive mouse mammary carcinoma (Shionogi) cells in culture. J Steroid Biochem. 1988 Nov;31(5):845-52. [3]. Crawford ED, et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med. 1989 Aug 17;321(7):419-24. [4]. Marchetti B, et al. Characteristics of flutamide action on prostatic and testicular functions in the rat. J Steroid Biochem. 1988 Jun;29(6):691-8. Chemical & Physical Properties Molecular Formula C11H11F3N2O3 Exact Mass 276.072174 PSA 74.92000 Index of Refraction 1.521 InChIKey MKXKFYHWDHIYRV-UHFFFAOYSA-N Storage condition Store at RT
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 30.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified
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