CAS Number41078-02-8
Synonyms3,7-dihydro-3-propyl-1H-purine-2,6-dione; enprophylline; 3-propylxanthine; Enprofilina [INN-Spanish]; EINECS 255-201-8; 3-propyl-7H-purine-2,6-dione; Enprofilina; Nilyph; Oxeze; Enprofyllinum [INN-Latin]; Enprofyllinum; 3-propylxanthine (PX); MFCD00043205; 3-n-propylxanthine
Molecular FormulaC8H10O2N4
Molecular Weight194.19
Purity99%
Density1.367 g/cm3
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 41078-02-8 |
| Catalog No. | 2A-9010332 |
| Chinese Name | 恩丙茶碱 |
| Synonyms | 3,7-dihydro-3-propyl-1H-purine-2,6-dione; enprophylline; 3-propylxanthine; Enprofilina [INN-Spanish]; EINECS 255-201-8; 3-propyl-7H-purine-2,6-dione; Enprofilina; Nilyph; Oxeze; Enprofyllinum [INN-Latin]; Enprofyllinum; 3-propylxanthine (PX); MFCD00043205; 3-n-propylxanthine |
| Molecular Formula | C8H10O2N4 |
| Molecular Weight | 194.19 |
| Purity | 99 |
| Density | 1.367 g/cm3 |
| Storage Condition | Sealed, cool, dry storage |
| Application | Amprofen is a selective and competitive A2B receptor antagonist with Ki of 7 μM. Amprofen also acts as a phosphodiesterase inhibitor. Amprofen can be used in the research of asthma and chronic obstruc |
| HTC | 2933990090 |
| MDL Number | MFCD00043205 |
| SMILES | CCCn1c(=O)[nH]c(=O)c2[nH]cnc21 |
| InChI | InChI=1S/C8H10N4O2/c1-2-3-12-6-5(9-4-10-6)7(13)11-8(12)14/h4H,2-3H2,1H3,(H,9,10)(H,11,13,14) |
| InChI Key | SIQPXVQCUCHWDI-UHFFFAOYSA-N |
| MSDS | msds/10332_1_41078_02_8.pdf |
| Use of | Enprofylline acts as a selective and competitive A2B receptor antagonist with the Ki of 7 μM. Enprofylline also acts as a phosphodiesterase inhibitor. Enprofylline can be used for the research of asthma, chronic obstructive pulmonary disease[1][2][3]. Properties Name enprofylline Synonym More Synonyms ENPROFYLLINE Biological Activity Description Enprofylline acts as a selective and competitive A2B receptor antagonist with the Ki of 7 μM. Enprofylline also acts as a phosphodiesterase inhibitor. Enprofylline can be used for the research of asthma, chronic obstructive pulmonary disease[1][2][3]. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor A2B receptor:7 μM (Ki) In Vitro Enprofylline (300 μM) completely blocks the release of IL-8 by N-ethylcarboxamidoadenosine (NECA)[1]. Enprofylline (10 μM) inhibits NECA (10 μM) induced proliferation in a concentration-dependent manner[2]. Cell Proliferation Assay[2] Cell Line: Human retinal endothelial cells (HRECs) Concentration: 10 μM Incubation Time: 24, 48, 72 hours Result: NECA (10 μM) induced a time-dependent increase in HREC proliferation as measured by cell counts, achieving approximately 80% of the density of cells exposed to normal growth medium for 3 days. Enprofylline (10 μM) completely blocked the proliferative effect of NECA when added concurrently with the analogue. References [1]. I Feoktistov, et al. Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. J Clin Invest. 1995 Oct;96(4):1979-86. [2]. M B Grant, et al. Proliferation, migration, and ERK activation in human retinal endothelial cells through A(2B) adenosine receptor stimulation. Invest Ophthalmol Vis Sci. 2001 Aug;42(9):2068-73. [3]. Jiang-Ning Yang, et al. Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine. Am J Physiol Heart Circ Physiol. 2009 Apr;296(4):H1141-9. Chemical & Physical Properties Molecular Formula C8H10N4O2 Exact Mass 194.08000 PSA 83.54000 Index of Refraction 1.583 InChIKey SIQPXVQCUCHWDI-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1H-Purine-2,6-dione, 3,7-dihydro-3-propyl- CAS REGISTRY NUMBER : 41078-02-8 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C8-H10-N4-O2 MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 22(Suppl 2),125,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- Volume(issue)/page/year: 22(Suppl 2),125,1990 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) REFERENCE : APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 49,313,1981 Safety Information Hazard Codes Xn: Harmful; Safety Phrases 36 HS Code 2933990090 Synthetic Route 6-amino-5-forma... CAS#:76194-09-7 ENPROFYLLINE CAS#:41078-02-8 Literature: Sakai, Ryosuke; Konno, Kayo; Yamamoto, Yasunori; Sanae, Fujiko; Takagi, Kenzo; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4039 - 4044 Diethoxymethyl ... CAS#:14036-06-7 5,6-diamino 1-n... CAS#:76194-07-5 ENPROFYLLINE CAS#:41078-02-8 Literature: Cottam, Howard B.; Shih, Hsiencheng; Tehrani, Lida R.; Wasson, D. Bruce; Carson, Dennis A. Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 2 - 9 5,6-diamino 1-n... CAS#:76194-07-5 ENPROFYLLINE CAS#:41078-02-8 Literature: Aktiebolaget Draco Patent: US4325956 A1, 1982 ; Precursor & DownStream Precursor 4 CAS#:14036-06-7 Diethoxymethyl ... CAS#:76194-07-5 5,6-diamino 1-n... CAS#:76194-05-3 6-amino-5-nitro... CAS#:53681-47-3 6-Amino-1-propy... DownStream 5 CAS#:31542-62-8 1,3-DIPROPYL-1H... CAS#:31542-63-9 1,3-Dipropyl-7-... CAS#:135462-21-4 3,7-dipropylpur... CAS#:121875-96-5 1-methyl-3,7-di... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Enlimomab pegol | 169802-84-0 | 2A-9010327 |
| Enloplatin | 111523-41-2 | 2A-9010328 |
| Enocitabine | 55726-47-1 | 2A-9010329 |
| Enoxacin | 74011-58-8 | 2A-9010330 |
| Enoximone | 77671-31-9 | 2A-9010331 |
| Enprostil | 73121-56-9 | 2A-9010333 |
| Entacapone | 130929-57-6 | 2A-9010335 |
| Entsufon | 55837-16-6 | 2A-9010337 |
| Eperezolid | 165800-04-4 | 2A-9010340 |
| Eperisone | 64840-90-0 | 2A-9010341 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS