CAS Number74011-58-8
Synonyms1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; MFCD00133308; 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; enoram; 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; Enoxacin; FLUMARK; Abenox; ENX; Gyramid; Enoxor; ci919; at-2266; Humark; Enoxen
Molecular FormulaC15H17O3N4F1
Molecular Weight320.32
Purity98%
Density1.4±0.1 g/cm3
Boiling Point569.9±50.0 °C at 760 mmHg
Melting Point220-224ºC
AppearanceOff-white to yellow crystals
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 74011-58-8 |
| Catalog No. | 2A-9010330 |
| Chinese Name | 依诺沙星 |
| Synonyms | 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; MFCD00133308; 1-Ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; enoram; 1-Ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid; Enoxacin; FLUMARK; Abenox; ENX; Gyramid; Enoxor; ci919; at-2266; Humark; Enoxen |
| Molecular Formula | C15H17O3N4F1 |
| Molecular Weight | 320.32 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 569.9±50.0 °C at 760 mmHg |
| Melting Point | 220-224ºC |
| Appearance | Off-white to yellow crystals |
| Storage Condition | Store in an airtight container in a cool, dry plac |
| Application | Enoxacin is a broad-spectrum antibacterial agent. |
| HTC | 29335995 |
| MDL Number | MFCD00133308 |
| SMILES | CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNCC3)nc21 |
| InChI | InChI=1S/C15H17FN4O3/c1-2-19-8-10(15(22)23)12(21)9-7-11(16)14(18-13(9)19)20-5-3-17-4-6-20/h7-8,17H,2-6H2,1H3,(H,22,23) |
| InChI Key | IDYZIJYBMGIQMJ-UHFFFAOYSA-N |
| MSDS | msds/10330_1_74011_58_8.pdf |
| Use of | Properties Name enoxacin Synonym More Synonyms Enoxacin Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection References [1]. Chin, N.-X. and H.C. Neu, In vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim. Antimicrobial agents and chemotherapy, 1983. 24(5): p. 754-763. [2]. Wijnands, W., T. Vree, and C. Herwaarden, Enoxacin decreases the clearance of theophylline in man. British journal of clinical pharmacology, 1985. 20(6): p. 583-588. Chemical & Physical Properties Molecular Formula C15H17FN4O3 Exact Mass 320.128479 PSA 87.46000 Index of Refraction 1.599 InChIKey IDYZIJYBMGIQMJ-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)- CAS REGISTRY NUMBER : 74011-58-8 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C15-H17-F-N4-O3 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : T66 BV EN GNJ CVQ E2 IF H- DT6M DNTJ HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Skin and Appendages - hair TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Primate - monkey DOSE/DURATION : TOXIC EFFECTS : Behavioral - food intake (animal) Gastrointestinal - hypermotility, diarrhea TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - changes in calcium TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Skin and Appendages - dermatitis, other (after systemic exposure) Nutritional and Gross Metabolic - weight loss or decreased weight gain TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : male 13 week(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females) Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system MUTATION DATA TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 200 ng/plate REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 281,207,1992 Safety Information Hazard Codes Xi WGK Germany 2 RTECS QN2800000 HS Code 29335995 Synthetic Route 7-(4-ethoxycarb... 92741-52-1 74011-58-8 Literature: Matsumoto; Miyamoto; Minamida; et al. Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 3 p. 673 - 679 Piperazine 1-ethyl-6-fluor... 114171-68-5 74011-58-8 Literature: Miyamoto; Egawa; Shibamori; Matsumoto Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 5 p. 1333 - 1339 ethyl N-ethyl-b... 23651-62-9 74011-58-8 Literature: Journal of Heterocyclic Chemistry, , vol. 24, # 5 p. 1333 - 1339 Precursor & DownStream Precursor 7 CAS#:110-85-0 Piperazine CAS#:114171-68-5 1-ethyl-6-fluor... CAS#:23651-62-9 ethyl N-ethyl-b... CAS#:82671-02-1 2,6-Dichloro-5-... DownStream 2 CAS#:87939-13-7 1-ETHYL-6-FLUOR... CAS#:74274-68-3 1-ethyl-6-fluor... |
| Transport Info | Product Name: Enoxacin |
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