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Drotaverine hydrochloride

Name: Drotaverine hydrochloride
Brand: 2A Biotech
SKU: 2A-9010260

CAS Number985-12-6

Synonyms6,7,3',4'-Tetraethoxy-1-benzal-1,2,3,4-tetrahydroisoquinoline hydrochloride; DROTAVERINE HCL; DROTAVERINE HYDROCHLORIDE; Drotaverine HCl ;1-[(3,4-Diethoxyphenyl)methylene]-6,7-diethoxy 1,2,3,4-tetrahydroisoquinoline HCL; Drotaverinium chloride; Isodihydroperparine hydrochloride; MFCD01754602; Drotaverin hydrochloride; (1Z)-1-(3,4-Diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride; (1Z)-1-[(3,4-Diethoxyphenyl)methyliden]-6,7-diethoxy-1,2,3,4-tetrahydroisochinolinhydrochlorid; Tetraspasmin-Lefa; (1Z)-1-(3,4-Diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1); No-Spa hydrochloride

Molecular FormulaC24H32ClNO4

Molecular Weight433.97

Purity≥95 (HPLC)%

Density1.097 g/cm3

Boiling Point564ºC at 760 mmHg

Melting Point208-212ºC

Appearancepowder

MSDSChinese English

Cat. No.: 2A-9010260 Purity: ≥95 (HPLC)%

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Quality Control of [ 985-12-6 ] Purity: ≥95 (HPLC)% SDS Specification MoL

Chemical & Physical Properties
CAS Number	985-12-6
Catalog No.	2A-9010260
Chinese Name	盐酸屈他维林
Synonyms	6,7,3',4'-Tetraethoxy-1-benzal-1,2,3,4-tetrahydroisoquinoline hydrochloride; DROTAVERINE HCL; DROTAVERINE HYDROCHLORIDE; Drotaverine HCl ;1-[(3,4-Diethoxyphenyl)methylene]-6,7-diethoxy 1,2,3,4-tetrahydroisoquinoline HCL; Drotaverinium chloride; Isodihydroperparine hydrochloride; MFCD01754602; Drotaverin hydrochloride; (1Z)-1-(3,4-Diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride; (1Z)-1-[(3,4-Diethoxyphenyl)methyliden]-6,7-diethoxy-1,2,3,4-tetrahydroisochinolinhydrochlorid; Tetraspasmin-Lefa; (1Z)-1-(3,4-Diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1); No-Spa hydrochloride
Molecular Formula	C24H32ClNO4
Molecular Weight	433.97
Purity	≥95 (HPLC)
Density	1.097 g/cm3
Boiling Point	564ºC at 760 mmHg
Melting Point	208-212ºC
Appearance	powder
Storage Condition	-20°C Freezer
Application	Drotaverine (HCl) is a cyclic nucleotide phosphodiesterase type 4 (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker that prevents the degradation of 3',5'-cyclic adenos
HTC	2933990090
MDL Number	MFCD00347721
SMILES	CCOC1=CC=C(/C=C2C3=C(CCN/2)C=C(OCC)C(OCC)=C3)C=C1OCC.[H]Cl
InChI	1S/C24H31NO4.ClH/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20;/h9-10,13-16,25H,5-8,11-12H2,1-4H3;1H/b20-13-;
InChI Key	JBFLYOLJRKJYNV-MASIZSFYSA-N
NACRES Code	NA.77
UNSPSC	12352200
MSDS	msds/10260_1_985_12_6.pdf
Use of	Properties Name (1Z)-1-[(3,4-diethoxyphenyl)methylidene]-6,7-diethoxy-3,4-dihydro-2H-isoquinoline,hydrochloride Synonym More Synonyms Drotaverine hydrochloride Biological Activity Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) References [1]. Patai Z, Guttman A, Mikus EG. Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine. Pharmacology. 2018;101(3-4):163-169. Chemical & Physical Properties Exact Mass 433.201996 PSA 48.95000 LogP 6.05600 InChIKey JBFLYOLJRKJYNV-MASIZSFYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Isoquinoline, 1,2,3,4-tetrahydro-6,7-diethoxy-1-((3,4-diethoxypheny l)methylene)-, hydrochloride CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 14600 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4035366 Safety Information HS Code 2933990090
Tax Rebate	13.0%
Supervision	None. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport Info	Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Drotaverine hydrochloride

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