CAS Number141626-36-0
SynonymsN-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide; Multaq; N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-1-benzofuran-5-yl)methanesulfonamide; Dronedarone; N-(2-Butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl)methanesulfonamide
Molecular FormulaC31H44N2O5S
Molecular Weight556.77
Purity98.00%
Density1.1±0.1 g/cm3
Boiling Point683.9±65.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 141626-36-0 |
| Catalog No. | 2A-9010257 |
| Chinese Name | 决奈达隆 |
| Synonyms | N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide; Multaq; N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-1-benzofuran-5-yl)methanesulfonamide; Dronedarone; N-(2-Butyl-3-{4-[3-(dibutylamino)propoxy]benzoyl}-1-benzofuran-5-yl)methanesulfonamide |
| Molecular Formula | C31H44N2O5S |
| Molecular Weight | 556.77 |
| Purity | 98.00 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 683.9±65.0 °C at 760 mmHg |
| Storage Condition | -20°C |
| Application | Dronedarone (Multaq) can act on paroxysmal and persistent atrial fibrillation or atrial flutter. |
| HTC | 3004909090 |
| MDL Number | C31H44N2O5S |
| SMILES | CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1 |
| InChI | InChI=1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3 |
| InChI Key | ZQTNQVWKHCQYLQ-UHFFFAOYSA-N |
| MSDS | msds/10257_1_141626_36_0.pdf |
| Use of | Dronedarone(Multaq) is a newer therapeutic agent with a structural resemblance to amiodarone and a better side effect profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF.IC50 value:Target: multichannel blocker Properties Name dronedarone Synonym More Synonyms Dronedarone Biological Activity Description Dronedarone(Multaq) is a newer therapeutic agent with a structural resemblance to amiodarone and a better side effect profile; it is a multichannel blocker with antiadrenergic properties and has been evaluated in both rate and rhythm control strategies in the management of AF.IC50 value:Target: multichannel blocker Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> mAChR Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Cardiovascular Disease References [1]. Piccinni C, et al.Trends in antiarrhythmic drug use after marketing authorization of dronedarone: comparison between Emilia Romagna (Italy) and Sweden.Eur J Clin Pharmacol. 2012 Sep 1. [2]. Benaim G, et al.The emerging role of amiodarone and dronedarone in Chagas disease.Nat Rev Cardiol. 2012 Aug 7. [3]. Rosman J, et al. Possible Proarrhythmia with Dronedarone.J Cardiovasc Electrophysiol. 2012 Jul 19. [4]. Kao DP, et al. Proarrhythmic Potential of Dronedarone: Emerging Evidence from Spontaneous Adverse Event Reporting.Pharmacotherapy. 2012 Jun 28. [5]. Manakshe G, Rao BH.Dronedarone-current status in management of atrial fibrillation.Indian Heart J. 2012 Mar-Apr;64(2):182-6. Epub 2012 Apr 28. Chemical & Physical Properties Molecular Formula C31H44N2O5S Exact Mass 556.297119 PSA 97.23000 Index of Refraction 1.564 InChIKey ZQTNQVWKHCQYLQ-UHFFFAOYSA-N Safety Information Hazard Codes Xi HS Code 3004909090 Synthetic Route 1420180-98-8 Dibutylamine Dronedarone 141626-36-0 Methanesulfonic... Dronedarone Imp... 1026754-33-5 Dronedarone 141626-36-0 1421316-69-9 Dronedarone 141626-36-0 Precursor & DownStream Precursor 3 CAS#:111-92-2 Dibutylamine CAS#:1912-32-9 Methanesulfonic... CAS#:627040-50-0 N-(3-(4-bromoph... DownStream 0 |
| Transport Info | Product Name: Dronedarone |
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