CAS Number4342-03-4
Synonymsdtic-aome; 5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide; Dtic-Dome; DTIC; DTIE; 5-(3,3-Dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide; 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide,DTIC; EINECS 224-396-1; 5-[(1E)-3,3-Dimethyltriaz-1-en-1-yl]-1H-imidazole-4-carboxamide; Dacarbazine; 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide DTIC; 5-(3,3-dimethyl-l-triazenyl)imidazole-4-carboxamide; MFCD00057167; 5-(3,3-dimethyltriazen-1-yl)-imidazole-4-carboxamide; DTIC Dome; DICARBAZINE; 5-(3,3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide; 5-(3,3-dimethyl-1-triazenyl)imidazole-4-carboxamide; deticene; 4-[(1E)-3,3-Dimethyl-1-triazen-1-yl]-1H-imidazole-5-carboxamide; DIC
Molecular FormulaC6H10N6O
Molecular Weight182.18
Purity98%
Density1.5±0.1 g/cm3
Boiling Point456.3±55.0 °C at 760 mmHg
Melting Point199-205°C
Appearancepowder or crystals
EINECS224-396-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 4342-03-4 |
| Catalog No. | 2A-9009982 |
| Chinese Name | 达卡巴嗪 |
| Synonyms | dtic-aome; 5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide; Dtic-Dome; DTIC; DTIE; 5-(3,3-Dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide; 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide,DTIC; EINECS 224-396-1; 5-[(1E)-3,3-Dimethyltriaz-1-en-1-yl]-1H-imidazole-4-carboxamide; Dacarbazine; 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide DTIC; 5-(3,3-dimethyl-l-triazenyl)imidazole-4-carboxamide; MFCD00057167; 5-(3,3-dimethyltriazen-1-yl)-imidazole-4-carboxamide; DTIC Dome; DICARBAZINE; 5-(3,3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide; 5-(3,3-dimethyl-1-triazenyl)imidazole-4-carboxamide; deticene; 4-[(1E)-3,3-Dimethyl-1-triazen-1-yl]-1H-imidazole-5-carboxamide; DIC |
| Molecular Formula | C6H10N6O |
| Molecular Weight | 182.18 |
| Purity | 98 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 456.3±55.0 °C at 760 mmHg |
| Melting Point | 199-205°C |
| Appearance | powder or crystals |
| Storage Condition | Store at room temperature, away from light, in a v |
| Application | Dacarbazine (DTIC-Dome; DTIC) has anti-melanoma activity. |
| EINECS | 224-396-1 |
| HTC | 2933290090 |
| PubChem ID | 24893683 |
| MDL Number | MFCD00057167 |
| SMILES | CN(C)\N=N\c1[nH]cnc1C(N)=O |
| InChI | 1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+ |
| InChI Key | FDKXTQMXEQVLRF-ZHACJKMWSA-N |
| NACRES Code | NA.85 |
| UNSPSC | 51102829 |
| Hazard Symbols | Transport |
| MSDS | msds/9982_1_4342_03_4.pdf |
| Bioactivity | Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas.Target: Nucleoside antimetabolite/analogApproved: May 1975Dacarbazine (DTIC) is the only single-agent approved by the Food and Drug Administration for treating metastatic melanoma. With DTIC as single agent, an approximately 20% objective response rate can be achieved with median response duration of 5 to 6 months and complete response rates of 5% [1]. Dacarbazine (DTIC) has activity in advanced previously untreated pancreatic islet cell tumors [2]. In the intent-to-treat population, median survival time was 7.7 months for patients treated with temozolomide and 6.4 months for those treated with DTIC (hazards ratio, 1.18; 95% confidence interval [CI], 0.92 to 1.52). Median PFS time was significantly longer in the temozolomide-treated group (1.9 months) than in the DTIC-treated group (1.5 months) (P = .012; hazards ratio, 1.37; 95% CI, 1.07 to 1.75) [3]. Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Cancer References [1]. Serrone, L., et al., Dacarbazine-based chemotherapy for metastatic melanoma: thirty-year experience overview. J Exp Clin Cancer Res, 2000. 19(1): p. 21-34. [2]. Ramanathan, R.K., et al., Phase II trial of dacarbazine (DTIC) in advanced pancreatic islet cell carcinoma. Study of the Eastern Cooperative Oncology Group-E6282. Ann Oncol, 2001. 12(8): p. 1139-43. [3]. Middleton, M.R., et al., Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. J Clin Oncol, 2000. 18(1): p. 158-66. Chemical & Physical Properties Density 1.5±0.1 g/cm3 Boiling Point 456.3±55.0 °C at 760 mmHg Melting Point 199-205°C Molecular Formula C6H10N6O Molecular Weight 182.183 Flash Point 229.7±31.5 °C Exact Mass 182.091614 PSA 99.73000 LogP -0.28 Vapour Pressure 0.0±1.1 mmHg at 25°C Index of Refraction 1.678 InChIKey FDKXTQMXEQVLRF-ZHACJKMWSA-O SMILES C[NH+](C)N=Nc1nc[nH]c1C(N)=O Storage condition 2-8°C |
| Use of | Properties Articles46 Name dacarbazine Synonym More Synonyms Dacarbazine Biological Activity Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Cancer References [1]. Serrone, L., et al., Dacarbazine-based chemotherapy for metastatic melanoma: thirty-year experience overview. J Exp Clin Cancer Res, 2000. 19(1): p. 21-34. [2]. Ramanathan, R.K., et al., Phase II trial of dacarbazine (DTIC) in advanced pancreatic islet cell carcinoma. Study of the Eastern Cooperative Oncology Group-E6282. Ann Oncol, 2001. 12(8): p. 1139-43. [3]. Middleton, M.R., et al., Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma. J Clin Oncol, 2000. 18(1): p. 158-66. Chemical & Physical Properties Molecular Formula C6H10N6O Exact Mass 182.091614 PSA 99.73000 LogP -0.28 Index of Refraction 1.678 InChIKey FDKXTQMXEQVLRF-ZHACJKMWSA-O |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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