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Cytochalasine structure, CAS 36011-19-5

Cytochalasine

CAS Number36011-19-5

SynonymsMFCD00005178; EINECS 252-835-7; CYTOCHALACINE; CYTOCHALASIN 3; CYTOCHALICINE; CYTOCHALASIN E,ASPERGILLUS CLAVATUS; (7s,13e,16s,18r,19e)-18-dimethyl-10-phenyl

Molecular FormulaC28H33NO7

Molecular Weight507.62

Purity98%

Density1.3±0.1 g/cm3

Boiling Point705.1±60.0 °C at 760 mmHg

Melting Point206ºC

Flash Point

Appearanceready-to-use solution

EINECS

MSDSChineseEnglish

Symbol6.1(a)

Signal WordWarning

Cat. No.: 2A-9009976 Purity: 98%
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Quality Control of [ 36011-19-5 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number36011-19-5
Catalog No.2A-9009976
Chinese Name细胞松弛素E
SynonymsMFCD00005178; EINECS 252-835-7; CYTOCHALACINE; CYTOCHALASIN 3; CYTOCHALICINE; CYTOCHALASIN E,ASPERGILLUS CLAVATUS; (7s,13e,16s,18r,19e)-18-dimethyl-10-phenyl
Molecular FormulaC28H33NO7
Molecular Weight507.62
Purity98
Density1.3±0.1 g/cm3
Boiling Point705.1±60.0 °C at 760 mmHg
Melting Point206ºC
Appearanceready-to-use solution
Storage Condition−20°C
PackagingI
ApplicationCytochalasin E, an epoxide containing an Aspergillus-derived fungal metabolite that inhibits angiogenesis and tumor growth, is a potent actin depolymerizer that binds to and caps the barbed ends of ac
HTC29349990
PubChem ID329775013
MDL NumberMFCD00077706
SMILES[H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4
InChI1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
InChI KeySDZRWUKZFQQKKV-JHADDHBZSA-N
Beilstein/REAXYS1632828
NACRES CodeNA.85
UNSPSC51102829
Hazard Symbols6.1(a)
MSDSmsds/9976_1_36011_19_5.pdf
BioactivityCytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy In Vitro Cytochalasin E prominently inhibits the growth of A549 cells in a dose-dependent manner[3]. Cytochalasin E could induce the up-regulation of autophagy-related protein (LC3-II) and SQSTM1/p62[3]. References [1]. Udagawa T, et al. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesisand tumor growth. J Pharmacol Exp Ther. 2000 Aug;294(2):421-7. [2]. Lu QY, et al. Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenicmodel. Clin Cancer Res. 2005 Feb 15;11(4):1675-83. [3]. Takanezawa Y, et al. Variation in the activity of distinct cytochalasins as autophagy inhibitiors in human lung A549 cells. Biochem Biophys Res Commun. 2017 Dec 16;494(3-4):641-647. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 705.1±60.0 °C at 760 mmHg Melting Point 206ºC Molecular Formula C28H33NO7 Molecular Weight 495.564 Flash Point 380.2±32.9 °C Exact Mass 495.225708 PSA 114.46000 LogP 1.92 Vapour Pressure 0.0±2.4 mmHg at 25°C Index of Refraction 1.608 InChIKey LAJXCUNOQSHRJO-PSAOVZEXSA-N SMILES CC1CC=CC2C3OC3(C)C(C)C3C(Cc4ccccc4)NC(=O)C23OC(=O)OC=CC(C)(O)C1=O Storage condition −20°C
Use ofCytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation[1][2]. Properties Articles30 Name cytochalasin e Synonym More Synonyms Cytochalasin E Biological Activity Description Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy References [1]. Udagawa T, et al. Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesisand tumor growth. J Pharmacol Exp Ther. 2000 Aug;294(2):421-7. [2]. Lu QY, et al. Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenicmodel. Clin Cancer Res. 2005 Feb 15;11(4):1675-83. Chemical & Physical Properties Molecular Formula C28H33NO7 Exact Mass 495.225708 PSA 114.46000 Index of Refraction 1.608 InChIKey LAJXCUNOQSHRJO-PSAOVZEXSA-N
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1544 International Maritime Transport Danger Regulations: 1544 International Air Transport Danger Regulations: 1544 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: ALKALOIDS, SOLID, N.O.S. (21,23-Dioxa[13]cytochalasa-13,19-diene-1,17,22-trione, 6,7- epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E)-) IMDG Code: ALKALOIDS, SOLID, N.O.S. (21,23-Dioxa[13]cytochalasa-13,19-diene-1,17,22-trione, 6,7- epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E)-) International Air Transport Risk Regulations: Alkaloids, solid, n.o.s. (21,23-Dioxa[13]cytochalasa-13,19-diene-1,17,22-trione, 6,7-epoxy- 18-hydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E)-) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available If applicable, the chemical meets the requirements of the Regulations on the Safety Management of Hazardous Chemicals (adopted by the State Council on January 9, 2002).
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