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Cytochalasin D structure, CAS 22144-77-0

Cytochalasin D

CAS Number22144-77-0

SynonymsMethylmalonate; CYTOCHALACIND; Zygosporin A; Lygosporin A; CYTOCHALICIND; MFCD00077706; 19-trien-17-one; Cytochalasin D,Zygosporin A; CYTOCHALASIN D; Cytohalasin d; EINECS 244-804-1; 7,18-Dihydroxy-10-phenyl-5,16,18-trimethyl-(11)cytochalas-21-acetoxy-6(12),13,19-trien-17-one

Molecular FormulaC30H37NO6

Molecular Weight507.62

Purity98%

Density1.2±0.1 g/cm3

Boiling Point712.1±60.0 °C at 760 mmHg

Melting Point255-260ºC

Flash Point

Appearanceready-to-use solution

EINECS

MSDSChineseEnglish

Symbol6.1(a)

Signal WordWarning

Cat. No.: 2A-9009975 Purity: 98%
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Quality Control of [ 22144-77-0 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number22144-77-0
Catalog No.2A-9009975
Chinese Name细胞松弛素D
SynonymsMethylmalonate; CYTOCHALACIND; Zygosporin A; Lygosporin A; CYTOCHALICIND; MFCD00077706; 19-trien-17-one; Cytochalasin D,Zygosporin A; CYTOCHALASIN D; Cytohalasin d; EINECS 244-804-1; 7,18-Dihydroxy-10-phenyl-5,16,18-trimethyl-(11)cytochalas-21-acetoxy-6(12),13,19-trien-17-one
Molecular FormulaC30H37NO6
Molecular Weight507.62
Purity98
Density1.2±0.1 g/cm3
Boiling Point712.1±60.0 °C at 760 mmHg
Melting Point255-260ºC
Appearanceready-to-use solution
Water SolubilityDMSO: soluble
Storage Condition-20℃
PackagingI
ApplicationCytochalasin D (Zygosporin A; NSC 209835) is a potent, cell-permeable inhibitor of actin polymerization produced by fungi that inhibits the G-actin-cofilin interaction by binding to G-actin. Cytochala
PubChem ID329775013
MDL NumberMFCD00077706
SMILES[H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4
InChI1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
InChI KeySDZRWUKZFQQKKV-JHADDHBZSA-N
Beilstein/REAXYS1632828
NACRES CodeNA.85
UNSPSC51102829
Hazard Symbols6.1(a)
MSDSmsds/9975_1_22144_77_0.pdf
BioactivityCytochalasin D (Zygosporin A; NSC 209835) is a potent and cell-permeable inhibitor of actin polymerization derived from fungus, inhibits the G-actin-cofilin interaction by binding to G-actin. Cytochalasin D (Zygosporin A; NSC 209835) also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells[1][2][3]. Related Catalog Signaling Pathways >> Cytoskeleton >> Arp2/3 Complex Research Areas >> Others Target G-actin[1] References [1]. Shoji K, et al. Cytochalasin D acts as an inhibitor of the actin-cofilin interaction. Biochem Biophys Res Commun. 2012 Jul 20;424(1):52-7. [2]. Flanagan MD, et al. Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem. 1980 Feb 10;255(3):835-8. [3]. May JA, et al. GPIIb-IIIa antagonists cause rapid disaggregation of platelets pre-treated with cytochalasin D. Evidence that the stability of platelet aggregates depends on normal cytoskeletal assembly. Platelets. 1998;9(3-4):227-32. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 712.1±60.0 °C at 760 mmHg Melting Point 255-260ºC Molecular Formula C30H37NO6 Molecular Weight 507.618 Flash Point 384.5±32.9 °C Exact Mass 507.262085 PSA 112.93000 LogP 2.64 Vapour Pressure 0.0±2.4 mmHg at 25°C Index of Refraction 1.597 InChIKey SDZRWUKZFQQKKV-IBUWGYDRSA-N SMILES C=C1C(C)C2C(Cc3ccccc3)NC(=O)C23C(OC(C)=O)C=CC(C)(O)C(=O)C(C)CC=CC3C1O Storage condition −20°C Water Solubility DMSO: soluble
Use ofCytochalasin D (Zygosporin A; NSC 209835) is a potent and cell-permeable inhibitor of actin polymerization derived from fungus, inhibits the G-actin-cofilin interaction by binding to G-actin. Cytochalasin D (Zygosporin A; NSC 209835) also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells[1][2][3]. Properties Articles254 Name cytochalasin D Synonym More Synonyms Lygosporin A Biological Activity Description Cytochalasin D (Zygosporin A; NSC 209835) is a potent and cell-permeable inhibitor of actin polymerization derived from fungus, inhibits the G-actin-cofilin interaction by binding to G-actin. Cytochalasin D (Zygosporin A; NSC 209835) also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells[1][2][3]. Related Catalog Research Areas >> Others G-actin[1] References [1]. Shoji K, et al. Cytochalasin D acts as an inhibitor of the actin-cofilin interaction. Biochem Biophys Res Commun. 2012 Jul 20;424(1):52-7. [2]. Flanagan MD, et al. Cytochalasins block actin filament elongation by binding to high affinity sites associated with F-actin. J Biol Chem. 1980 Feb 10;255(3):835-8. [3]. May JA, et al. GPIIb-IIIa antagonists cause rapid disaggregation of platelets pre-treated with cytochalasin D. Evidence that the stability of platelet aggregates depends on normal cytoskeletal assembly. Platelets. 1998;9(3-4):227-32. Chemical & Physical Properties Molecular Formula C30H37NO6 Exact Mass 507.262085 PSA 112.93000 Index of Refraction 1.597 InChIKey SDZRWUKZFQQKKV-IBUWGYDRSA-N Water Solubility DMSO: soluble
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 1544 International Maritime Transport Danger Regulations: 1544 International Air Transport Danger Regulations: 1544 14.2 United Nations shipping name European Land Transport Dangerous Regulations: ALKALOIDS, SOLID, N.O.S. (7(S),18(R)-Dihydroxy-16(S),18-dimethyl-10- phenyl[11]cytochalasa-6(12),13(E),19(E)-triene-1,17-dione 21(R)-acetate) IMDG: ALKALOIDS, SOLID, N.O.S. (7(S),18(R)-Dihydroxy-16(S),18-dimethyl-10- phenyl[11]cytochalasa-6(12),13(E),19(E)-triene-1,17-dione 21(R)-acetate) International air transport hazard regulations: Alkaloids, solid, n.o.s. (7(S),18(R)-Dihydroxy-16(S),18-dimethyl-10-phenyl[11]cytochalasa- 6(12),13(E),19(E)-triene-1,17-dione 21(R)-acetate) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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