CAS Number57808-65-8
SynonymsMFCD00661151; Closantel; N-{5-Chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide; rac-N-[5-chloro-4-[(R)-(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide; N-[5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide; (RS)-5'-chloro-4'-(4-chloro-α-cyanobenzyl)-3,5-diiodosalicyl-o-toluidide; N-{5-Chlor-4-[(4-chlorphenyl)(cyan)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodbenzolcarboxamid; N-(5-Chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide; UNII:EUL532EI54; EINECS 260-967-1
Molecular FormulaC22H14Cl2I2N2O2
Molecular Weight663.07
Purity98%
Density1.9±0.1 g/cm3
Boiling Point590.5±50.0 °C at 760 mmHg
Melting Point210 - 22ºC
AppearanceWhite to light yellow powder
EINECS260-967-1
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 57808-65-8 |
| Catalog No. | 2A-9009878 |
| Chinese Name | 氯氰碘柳胺 |
| Synonyms | MFCD00661151; Closantel; N-{5-Chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide; rac-N-[5-chloro-4-[(R)-(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide; N-[5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl]-2-hydroxy-3,5-diiodobenzamide; (RS)-5'-chloro-4'-(4-chloro-α-cyanobenzyl)-3,5-diiodosalicyl-o-toluidide; N-{5-Chlor-4-[(4-chlorphenyl)(cyan)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodbenzolcarboxamid; N-(5-Chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide; UNII:EUL532EI54; EINECS 260-967-1 |
| Molecular Formula | C22H14Cl2I2N2O2 |
| Molecular Weight | 663.07 |
| Purity | 98 |
| Density | 1.9±0.1 g/cm3 |
| Boiling Point | 590.5±50.0 °C at 760 mmHg |
| Melting Point | 210 - 22ºC |
| Appearance | White to light yellow powder |
| Storage Condition | 0-6°C |
| Packaging | III |
| Application | Closantel is a salicylanilide anthelmintic. |
| EINECS | 260-967-1 |
| PubChem ID | 329754809 |
| MDL Number | MFCD00661151 |
| SMILES | Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c3cc(I)cc(I)c3O |
| InChI | 1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30) |
| InChI Key | JMPFSEBWVLAJKM-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/9878_1_57808_65_8.pdf |
| Bioactivity | Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Bacon JA, et al. Comparative in vitro effects of closantel and selected beta-ketoamide anthelmintics on a gastrointestinal nematode and vertebrate liver cells. J Vet Pharmacol Ther. 1998 Jun;21(3):190-8. [2]. Macielag MJ, et al. Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria. J Med Chem. 1998 Jul 30;41(16):2939-45. [3]. Waruiru RM. Efficacy of closantel, albendazole and levamisole on an ivermectin resistant strain of Haemonchus contortus in sheep. Vet Parasitol. 1997 Dec 15;73(1-2):65-71. Chemical & Physical Properties Density 1.9±0.1 g/cm3 Boiling Point 590.5±50.0 °C at 760 mmHg Melting Point 210 - 22ºC Molecular Formula C22H14Cl2I2N2O2 Molecular Weight 663.074 Flash Point 310.9±30.1 °C Exact Mass 661.852173 PSA 73.12000 LogP 9.08 Vapour Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.736 InChIKey JMPFSEBWVLAJKM-UHFFFAOYSA-N SMILES Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c1cc(I)cc(I)c1O |
| Use of | Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals. Properties Articles28 Name closantel Synonym More Synonyms Closantel Biological Activity Description Closantel is a salicylanilide anthelmintic compound; exhibits different anthelmintic spectra and apparent toxicity in mammals. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Bacon JA, et al. Comparative in vitro effects of closantel and selected beta-ketoamide anthelmintics on a gastrointestinal nematode and vertebrate liver cells. J Vet Pharmacol Ther. 1998 Jun;21(3):190-8. [2]. Macielag MJ, et al. Substituted salicylanilides as inhibitors of two-component regulatory systems in bacteria. J Med Chem. 1998 Jul 30;41(16):2939-45. [3]. Waruiru RM. Efficacy of closantel, albendazole and levamisole on an ivermectin resistant strain of Haemonchus contortus in sheep. Vet Parasitol. 1997 Dec 15;73(1-2):65-71. Chemical & Physical Properties Exact Mass 661.852173 PSA 73.12000 Index of Refraction 1.736 InChIKey JMPFSEBWVLAJKM-UHFFFAOYSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 United Nations number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Closantel) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (Closantel) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Closantel) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special precautions No data available |
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