CAS Number60200-06-8
SynonymsClorsulon [Spanish]; EINECS 262-100-2; Clorsulonum [Latin]; 4-amino-6-trichlorovinyl-1,3-benzenedisulfonamide; 4-Amino-6-(trichlorovinyl)benzene-1,3-disulfonamide; Ivomec-F; 4-amino-6-(trichloroethenyl)benzene-1,3-disulfonamide; MFCD00072006; Clorsulone [French]; Clorsulon; Curatrem; 4-amino-6-trichloroethenyl-1,3-benzenedisulfonamide; 4-Amino-6-(trichlorethenyl)-1,3-benzoldisulfonamid; MK-401; 4-Amino-6-(trichlorovinyl)-1,3-benzenedisulfonamide
Molecular FormulaC8H8Cl3N3O4S2
Molecular Weight380.66
Purity98%
Density1.8±0.1 g/cm3
Boiling Point651.7±65.0 °C at 760 mmHg
Melting Point194-203°C
AppearanceWhite to off-white crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 60200-06-8 |
| Catalog No. | 2A-9009877 |
| Chinese Name | 氯舒隆 |
| Synonyms | Clorsulon [Spanish]; EINECS 262-100-2; Clorsulonum [Latin]; 4-amino-6-trichlorovinyl-1,3-benzenedisulfonamide; 4-Amino-6-(trichlorovinyl)benzene-1,3-disulfonamide; Ivomec-F; 4-amino-6-(trichloroethenyl)benzene-1,3-disulfonamide; MFCD00072006; Clorsulone [French]; Clorsulon; Curatrem; 4-amino-6-trichloroethenyl-1,3-benzenedisulfonamide; 4-Amino-6-(trichlorethenyl)-1,3-benzoldisulfonamid; MK-401; 4-Amino-6-(trichlorovinyl)-1,3-benzenedisulfonamide |
| Molecular Formula | C8H8Cl3N3O4S2 |
| Molecular Weight | 380.66 |
| Purity | 98 |
| Density | 1.8±0.1 g/cm3 |
| Boiling Point | 651.7±65.0 °C at 760 mmHg |
| Melting Point | 194-203°C |
| Appearance | White to off-white crystalline powder |
| Storage Condition | 0-6℃ |
| Application | Clorsulon can be used to treat Fasciola hepatica infection in cattle and sheep. |
| HTC | 2935009090 |
| PubChem ID | 329749439 |
| MDL Number | MFCD00072006 |
| SMILES | Nc1cc(\C(Cl)=C(\Cl)Cl)c(cc1S(N)(=O)=O)S(N)(=O)=O |
| InChI | 1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14,17)18)2-5(3)19(13,15)16/h1-2H,12H2,(H2,13,15,16)(H2,14,17,18) |
| InChI Key | QOVTVIYTBRHADL-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/9877_1_60200_06_8.pdf |
| Bioactivity | Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep.Target: AntiparasiticClorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. [1] Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep [1]. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation [2]. Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Mrozik, H., et al., 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20(9): p. 1225-7. [2]. Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92(3): p. 232-41. Chemical & Physical Properties Density 1.8±0.1 g/cm3 Boiling Point 651.7±65.0 °C at 760 mmHg Melting Point 194-203°C Molecular Formula C8H8Cl3N3O4S2 Molecular Weight 380.656 Flash Point 348.0±34.3 °C Exact Mass 378.902191 PSA 163.10000 LogP 1.04 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.665 InChIKey QOVTVIYTBRHADL-UHFFFAOYSA-N SMILES Nc1cc(C(Cl)=C(Cl)Cl)c(S(N)(=O)=O)cc1S(N)(=O)=O Storage condition 0-6°C |
| Use of | Properties Articles27 Name 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide Synonym More Synonyms Clorsulon Biological Activity Related Catalog Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Mrozik, H., et al., 4-amino-6-(trichloroethenyl)-1,3-benzenedisulfonamide, a new, potent fasciolicide. J Med Chem, 1977. 20(9): p. 1225-7. [2]. Meaney, M., et al., Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res, 2004. 92(3): p. 232-41. Chemical & Physical Properties Exact Mass 378.902191 PSA 163.10000 Index of Refraction 1.665 InChIKey QOVTVIYTBRHADL-UHFFFAOYSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Purity: 99.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: No dangerous goods IMDG Code: No dangerous goods International Air Transport Dangerous Regulations: No dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special precautions for users No data available |
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