CAS Number14984-68-0
Synonyms1-(2-((p-chloro-a-phenylbenzyl)oxy)ethyl)piperidine hydrochloride; MFCD00079012; 1-[2-[(4-Chlorophenyl)(phenyl)methoxy]ethyl]piperidine Hydrochloride; Piperidine, 1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]-, hydrochloride (1:1); Cloperastine hydrochloride; 4-Chlorobenzhydryl 2-(1-Piperidyl)ethyl Ether Hydrochloride; 1-{2-[(4-Chlorophenyl)(phenyl)methoxy]ethyl}piperidine hydrochloride (1:1); 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine,hydrochloride; EINECS 239-067-8
Molecular FormulaC20H25O1N1Cl2
Molecular Weight366.33
Purity98%
Boiling Point84°C 35mm
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 14984-68-0 |
| Catalog No. | 2A-9009869 |
| Chinese Name | 咳平盐酸盐 |
| Synonyms | 1-(2-((p-chloro-a-phenylbenzyl)oxy)ethyl)piperidine hydrochloride; MFCD00079012; 1-[2-[(4-Chlorophenyl)(phenyl)methoxy]ethyl]piperidine Hydrochloride; Piperidine, 1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]-, hydrochloride (1:1); Cloperastine hydrochloride; 4-Chlorobenzhydryl 2-(1-Piperidyl)ethyl Ether Hydrochloride; 1-{2-[(4-Chlorophenyl)(phenyl)methoxy]ethyl}piperidine hydrochloride (1:1); 1-[2-[(4-chlorophenyl)-phenylmethoxy]ethyl]piperidine,hydrochloride; EINECS 239-067-8 |
| Molecular Formula | C20H25O1N1Cl2 |
| Molecular Weight | 366.33 |
| Purity | 98 |
| Boiling Point | 84°C 35mm |
| Application | Cloperastine hydrochloride inhibits hERG K+ currents with an IC50 of 27 nM in a concentration-dependent manner. |
| HTC | 2933399090 |
| MDL Number | MFCD00079012 |
| SMILES | Cl.Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1 |
| InChI | InChI=1S/C20H24ClNO.ClH/c21-19-11-9-18(10-12-19)20(17-7-3-1-4-8-17)23-16-15-22-13-5-2-6-14-22;/h1,3-4,7-12,20H,2,5-6,13-16H2;1H |
| InChI Key | UNPLRYRWJLTVAE-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/9869_1_14984_68_0.pdf |
| Bioactivity | Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM[1]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel Target 27 nM (K+ currents)[1] In Vitro Cloperastine inhibits the hERG K+ currents in a concentrationdependent manner with an IC50 value of 27 nM[1]. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects[2]. In Vivo In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasicaction potential (MAP) duration without affecting PR interval or QRS width[1]. Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively[2]. References [1]. Takahara A, et al. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. J Pharmacol Sci. 2012;120(3):165-75. [2]. Catania MA, et al. Pharmacological and clinical overview of cloperastine in treatment of cough. Ther Clin Risk Manag. 2011;7:83-92. Chemical & Physical Properties Boiling Point 84°C 35mm Molecular Formula C20H25Cl2NO Molecular Weight 366.325 Flash Point 210.2ºC Exact Mass 365.131317 PSA 12.47000 LogP 5.67180 Vapour Pressure 2.15E-07mmHg at 25°C Index of Refraction 1.414 InChIKey UNPLRYRWJLTVAE-UHFFFAOYSA-N SMILES Cl.Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1 |
| Use of | Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM[1]. Properties Articles14 Name Cloperastine hydrochloride Synonym More Synonyms Cloperastine hydrochloride Biological Activity Description Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM[1]. Related Catalog Research Areas >> Inflammation/Immunology Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel 27 nM (K+ currents)[1] In Vitro Cloperastine inhibits the hERG K+ currents in a concentrationdependent manner with an IC50 value of 27 nM[1]. Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects[2]. References [1]. Takahara A, et al. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. J Pharmacol Sci. 2012;120(3):165-75. [2]. Catania MA, et al. Pharmacological and clinical overview of cloperastine in treatment of cough. Ther Clin Risk Manag. 2011;7:83-92. Chemical & Physical Properties Exact Mass 365.131317 PSA 12.47000 LogP 5.67180 Index of Refraction 1.414 InChIKey UNPLRYRWJLTVAE-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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