CAS Number636-54-4
SynonymsEINECS 211-261-7; Brinaldix; DT-327; 4-Chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide; CLOPAMIDUM; ChlosudiMepriMyl; Adurix; MFCD00941495; 4-Chloro-N-(2,6-dimethylpiperidino)-3-sulfamoylbenzamide; 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethylpiperidin-1-yl)benzamide; Aquex; 4-Chloro-N-(2,6-dimethylpiperidin-1-yl)-3-sulfamoylbenzamide; 4-Chloro-N-(2,6-dimethyl-1-piperidinyl)-3-sulfamoylbenzamide
Molecular FormulaC14H20ClN3O3S
Molecular Weight345.84
Purity98%
Density1.4±0.1 g/cm3
Melting Point244-246ºC
AppearanceWhite to light yellow crystalline powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 636-54-4 |
| Catalog No. | 2A-9009867 |
| Chinese Name | 氯帕胺 |
| Synonyms | EINECS 211-261-7; Brinaldix; DT-327; 4-Chloro-N-[(2R,6S)-2,6-dimethyl-1-piperidinyl]-3-sulfamoylbenzamide; CLOPAMIDUM; ChlosudiMepriMyl; Adurix; MFCD00941495; 4-Chloro-N-(2,6-dimethylpiperidino)-3-sulfamoylbenzamide; 3-(aminosulfonyl)-4-chloro-N-(2,6-dimethylpiperidin-1-yl)benzamide; Aquex; 4-Chloro-N-(2,6-dimethylpiperidin-1-yl)-3-sulfamoylbenzamide; 4-Chloro-N-(2,6-dimethyl-1-piperidinyl)-3-sulfamoylbenzamide |
| Molecular Formula | C14H20ClN3O3S |
| Molecular Weight | 345.84 |
| Purity | 98 |
| Density | 1.4±0.1 g/cm3 |
| Melting Point | 244-246ºC |
| Appearance | White to light yellow crystalline powder |
| Storage Condition | 2-8°C |
| Application | Clopamide is an orally active thiazide diuretic that inhibits the sodium-coupled chloride cotransporter SLC12A3. Clopamide is used in research into hypertension and heart failure. |
| HTC | 2935009090 |
| PubChem ID | 329831180 |
| MDL Number | MFCD00941495 |
| SMILES | C[C@@H]1CCC[C@H](C)N1NC(=O)c2ccc(Cl)c(c2)S(N)(=O)=O |
| InChI | 1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)/t9-,10+ |
| InChI Key | LBXHRAWDUMTPSE-AOOOYVTPSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/9867_1_636_54_4.pdf |
| Use of | Properties Name Clopamide Synonym More Synonyms Clopamide Biological Activity Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease In Vitro Clopamide is actively secreted by renal tubular cells and the True Tubular Excretion Fraction (TTEF) value is 10%[3]. References [1]. J J McNeil, et al. Clopamide: plasma concentrations and diuretic effect in humans. Clin Pharmacol Ther. 1987 Sep;42(3):299-304. [2]. Yoshiteru Noutoshi, et al. Diuretics prime plant immunity in Arabidopsis thaliana. PLoS One. 2012;7(10):e48443. [3]. B Odlind, et al. Renal tubular secretion and effects of chlorothiazide, hydrochlorothiazide and clopamide: a study in the avian kidney. Acta Pharmacol Toxicol (Copenh). 1982 Sep;51(3):187-97. [4]. E Müller-Schweinitzer, et al. Interaction of cyclosporine-A with the renin-angiotensin system in canine veins. Naunyn Schmiedebergs Arch Pharmacol. 1989 Aug;340(2):252-7. Chemical & Physical Properties Exact Mass 345.091400 PSA 100.88000 Index of Refraction 1.613 InChIKey LBXHRAWDUMTPSE-AOOOYVTPSA-N Safety Information Signal Word Danger Hazard Statements H317-H334 Precautionary Statements P261-P280-P284-P304 + P340-P342 + P311 Hazard Codes Xn Safety Phrases 36 RIDADR NONH for all modes of transport WGK Germany 3 HS Code 2935009090 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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