CAS Number2438-72-4
SynonymsFeximac; Bufexamaco; Flogicid; Bufexamacum; Bufexamic acid; MFCD00078936; 2-(4-Butoxyphenyl)-N-hydroxyacetamide; 4-butoxy-N-hydroxybenzeneacetamide; Droxaryl; 2-(4-butoxyphenyl)acetohydroxamic acid; 2-(p-Butoxyphenyl)acetohydroxamic acid; 2-(4-butoxyphenyl)acethydroxamic acid; EINECS 219-451-1; Bufexamac; Malipuran; Parfenac
Molecular FormulaC12H17NO3
Molecular Weight223.27
Purity98%
Density1.1±0.1 g/cm3
Melting Point161 - 162ºC
AppearanceSolid;White to Almost white powder to crystal
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2438-72-4 |
| Catalog No. | 2A-9009475 |
| Chinese Name | 丁苯羟酸 |
| Synonyms | Feximac; Bufexamaco; Flogicid; Bufexamacum; Bufexamic acid; MFCD00078936; 2-(4-Butoxyphenyl)-N-hydroxyacetamide; 4-butoxy-N-hydroxybenzeneacetamide; Droxaryl; 2-(4-butoxyphenyl)acetohydroxamic acid; 2-(p-Butoxyphenyl)acetohydroxamic acid; 2-(4-butoxyphenyl)acethydroxamic acid; EINECS 219-451-1; Bufexamac; Malipuran; Parfenac |
| Molecular Formula | C12H17NO3 |
| Molecular Weight | 223.27 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Melting Point | 161 - 162ºC |
| Appearance | Solid;White to Almost white powder to crystal |
| Water Solubility | Water solubility: insoluble |
| Storage Condition | Warehouse Ventilation Low Temperature Drying |
| Application | Bufexamac is an inhibitor of HDAC6 and HDAC10 and has anti-inflammatory activity. |
| HTC | 2924299090 |
| PubChem ID | 329773173 |
| MDL Number | MFCD00078936 |
| SMILES | CCCCOc1ccc(CC(=O)NO)cc1 |
| InChI | 1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14) |
| InChI Key | MXJWRABVEGLYDG-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Hazard Symbols | Transport |
| MSDS | msds/9475_1_2438_72_4.pdf |
| Bioactivity | Bufexamac is a class IIB histone deacetylases (HDAC6 and HDAC10) inhibitor used as an anti-inflammatory agent. Related Catalog Research Areas >> Inflammation/Immunology Target HDAC6:10.7 μM (Kd app) HDAC10:12.3 μM (Kd app) HDAC8:235 μM (Kd app) HDAC3:341 μM (Kd app) References [1]. Bantscheff, M., et al., Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol, 2011. 29(3): p. 255-65. [2]. Kranke, B., et al., Epidemiological significance of bufexamac as a frequent and relevant contact sensitizer. Contact Dermatitis, 1997. 36(4): p. 212-5. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Melting Point 161 - 162ºC Molecular Formula C12H17NO3 Molecular Weight 223.268 Exact Mass 223.120850 PSA 58.56000 LogP 1.70 Index of Refraction 1.530 InChIKey MXJWRABVEGLYDG-UHFFFAOYSA-N SMILES CCCCOc1ccc(CC(=O)NO)cc1 |
| Use of | Bufexamac is a class IIB histone deacetylases (HDAC6 and HDAC10) inhibitor used as an anti-inflammatory agent. Properties Articles26 Name bufexamac Synonym More Synonyms Bufexamac Biological Activity Description Bufexamac is a class IIB histone deacetylases (HDAC6 and HDAC10) inhibitor used as an anti-inflammatory agent. Related Catalog Research Areas >> Inflammation/Immunology HDAC6:10.7 μM (Kd app) HDAC10:12.3 μM (Kd app) HDAC8:235 μM (Kd app) HDAC3:341 μM (Kd app) References [1]. Bantscheff, M., et al., Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat Biotechnol, 2011. 29(3): p. 255-65. Chemical & Physical Properties Molecular Formula C12H17NO3 Exact Mass 223.120850 PSA 58.56000 Index of Refraction 1.530 InChIKey MXJWRABVEGLYDG-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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