| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1223403-58-4 |
| Catalog No. | 2A-9093875 |
| Chinese Name | 拉罗替尼 |
| Synonyms | LOXO-101; Larotrectinib; UNII:PF9462I9HX; MFCD28902192 |
| Molecular Formula | C21H22O2N6F2 |
| Molecular Weight | 428.44 |
| Density | 1.6±0.1 g/cm3 |
| Appearance | yellow solid |
| Storage Condition | -20℃ |
| Application | Larotrectinib (LOXO-101) is an ATP-competitive, orally selective inhibitor with nanomolar 50% inhibitory concentrations of three subtypes of tropomyosin-related kinase (TRK) family receptors (TRKA, B |
| PubChem ID | 96042437 |
| MDL Number | MFCD28902192 |
| SMILES | O=C(Nc1cnn2ccc(N3CCCC3c3cc(F)ccc3F)nc12)N1CCC(O)C1 |
| InChI | InChI=1S/C21H22F2N6O2/c22-13-3-4-16(23)15(10-13)18-2-1-7-28(18)19-6-9-29-20(26-19)17(11-24-29)25-21(31)27-8-5-14(30)12-27/h3-4,6,9-11,14,18,30H,1-2,5,7-8,12H2,(H,25,31)/t14-,18+/m0/s1 |
| InChI Key | NYNZQNWKBKUAII-KBXCAEBGSA-N |
| MSDS | msds/93875_1_1223403_58_4.pdf |
| Transport Info | Product Name: Larotinib |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| CHLOROCARBONYLSULFENYL CHLORIDE | 2757-23-5 | 2A-9093862 |
| 3,6-DIOXA-1,8-OCTANEDITHIOL | 14970-87-7 | 2A-9093865 |
| sapropterin | 62989-33-7 | 2A-9093866 |
| MK-4827 (tosylate) | 1038915-73-9 | 2A-9093868 |
| 3-Formyl-2-nitrobenzoic acid methyl ester | 138229-59-1 | 2A-9093874 |
| LOXO-101 (sulfate) | 1223405-08-0 | 2A-9093876 |
| PF 04449913 | 1095173-27-5 | 2A-9093881 |
| Propanoic acid, 3-[(4-ethyl-1H-pyrazol-3-yl)amino]-3-oxo-, methyl ester (9CI) | 779353-62-7 | 2A-9093896 |
| n/a | 1310731-87-3 | 2A-9093898 |
| n/a | 88057-03-8 | 2A-9093917 |
| Browse all Specialty Chemicals products » | ||
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