CAS Number2086-83-1
SynonymsBerberine; EINECS 211-195-9; 5,6-Dihydro-9,10-dimethoxybenzo[g]1,3-benzodioxolo[5,6-a]quinolizinium; 9,10-Dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium; 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium; Berberin; 5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium; MFCD00011939; 5,6-dihydro-9,10-dimethoxy-1,3-benzodioxolo[5,6-a]benzo[g]quinolizinium; 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium
Molecular FormulaC20H18O4N1
Molecular Weight336.37
Purity98%
Melting Point204-206ºC (dec.)
Appearanceyellow
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2086-83-1 |
| Catalog No. | 2A-9009367 |
| Chinese Name | 黄连素 |
| Synonyms | Berberine; EINECS 211-195-9; 5,6-Dihydro-9,10-dimethoxybenzo[g]1,3-benzodioxolo[5,6-a]quinolizinium; 9,10-Dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium; 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium; Berberin; 5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium; MFCD00011939; 5,6-dihydro-9,10-dimethoxy-1,3-benzodioxolo[5,6-a]benzo[g]quinolizinium; 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium |
| Molecular Formula | C20H18O4N1 |
| Molecular Weight | 336.37 |
| Purity | 98 |
| Melting Point | 204-206ºC (dec.) |
| Appearance | yellow |
| Storage Condition | Low temperature ventilation and low drying, limite |
| Packaging | III |
| Application | Berberine is a natural alkaloid that can reduce cell apoptosis and has antioxidant and anti-inflammatory effects. |
| HTC | 2934999090 |
| MDL Number | MFCD01175817 |
| SMILES | COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2 |
| InChI | InChI=1S/C20H18NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-10H,5-6,11H2,1-2H3/q+1 |
| InChI Key | YBHILYKTIRIUTE-UHFFFAOYSA-N |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/9367_1_2086_83_1.pdf |
| Use of | Berberine is a natural alkaline, reduces apoptosis, with potent anti-oxidative and anti-inflammatory effect[1]. Properties Name berberine Synonym More Synonyms Berberine Biological Activity Description Berberine is a natural alkaline, reduces apoptosis, with potent anti-oxidative and anti-inflammatory effect[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology References [1]. Ma X, et al. Berberine exhibits antioxidative effects and reduces apoptosis of the vaginal epithelium in bacterial vaginosis. Exp Ther Med. 2019 Sep;18(3):2122-2130. Chemical & Physical Properties Molecular Formula C20H18NO4+ Exact Mass 336.123047 PSA 40.80000 LogP -0.99 InChIKey YBHILYKTIRIUTE-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Berbinium, 7,8,13,13a-tetrahydro-9,10-dimethoxy-2,3-(methylenedi oxy)- CAS REGISTRY NUMBER : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C20-H18-N-O4 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value MUTATION DATA TYPE OF TEST : DNA adduct TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981 Safety Information Hazard Codes Xi RIDADR UN 1544 WGK Germany 2 RTECS DR9866400 Packaging Group III Hazard Class 6.1(b) HS Code 2934999090 Synthetic Route CAS#:47474-50-0 CAS#:2086-83-1 Literature: Natural Product Research, , vol. 28, # 7 p. 413 - 419 6H-Benzo[g]-1,3... CAS#:29074-38-2 8-Oxyberberine CAS#:549-21-3 CAS#:2086-83-1 3-[3,4-dihydro-... CAS#:64939-64-6 Literature: Helvetica Chimica Acta, , vol. 85, # 4 p. 1069 - 1078 CAS#:94272-86-3 CAS#:2086-83-1 Literature: Hanaoka, Miyoji; Ashimori, Atsuyuki; Yasuda, Shingo Heterocycles, 1984 , vol. 22, # 10 p. 2263 - 2264 Precursor & DownStream Precursor 5 CAS#:29074-38-2 6H-Benzo[g]-1,3... CAS#:633-65-8 Berberine hydro... CAS#:113975-46-5 (±)-8-cyano-1... CAS#:84229-90-3 spirobenzylisoq... DownStream 8 CAS#:483-15-8 Dihydroberberine CAS#:3486-66-6 CAS#:21796-14-5 1,3-Dioxolo[4,5... CAS#:61138-60-1 Benzo[g]-1,3-be... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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