CAS Number483-04-5
SynonymsCircolene; EINECS 207-589-5; Pytetrahydroserpentine; Vincein; Ranitol; yochimbine; Vinceine; Lamuran; Methyl-(19α)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylat; fluoroajmalicine; Einecs 224-471-9; d-Yohimbine; δ-Yohimbine; RAUBASINE HYDROCHLORIDE; AJMALICINE HCL; (19α)-16,17-Didehydro-19-methyl-oxayohimban-16-carboxylic acid methyl ester; Methyl (19α)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate; Raubasil; Raubasine; Ajmalicine; RAUBASIN; ajmalicine,monohydrochloride; Tensyl; Sarpan; AJMALICIN HCL; Tetrahydroserpentine; Rauvasan; Vincain
Molecular FormulaC21H24O3N2
Molecular Weight352.43
Purity98%
Density1.3±0.1 g/cm3
Boiling Point524.0±50.0 °C at 760 mmHg
Melting Point258°C (rough estimate)
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 483-04-5 |
| Catalog No. | 2A-9009082 |
| Chinese Name | 萝巴新； 阿吗碱 |
| Synonyms | Circolene; EINECS 207-589-5; Pytetrahydroserpentine; Vincein; Ranitol; yochimbine; Vinceine; Lamuran; Methyl-(19α)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylat; fluoroajmalicine; Einecs 224-471-9; d-Yohimbine; δ-Yohimbine; RAUBASINE HYDROCHLORIDE; AJMALICINE HCL; (19α)-16,17-Didehydro-19-methyl-oxayohimban-16-carboxylic acid methyl ester; Methyl (19α)-19-methyl-16,17-didehydro-18-oxayohimban-16-carboxylate; Raubasil; Raubasine; Ajmalicine; RAUBASIN; ajmalicine,monohydrochloride; Tensyl; Sarpan; AJMALICIN HCL; Tetrahydroserpentine; Rauvasan; Vincain |
| Molecular Formula | C21H24O3N2 |
| Molecular Weight | 352.43 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 524.0±50.0 °C at 760 mmHg |
| Melting Point | 258°C (rough estimate) |
| Storage Condition | 1. Store in argon-filled seal. |
| Packaging | III |
| Application | Ajmalicine (Raubasine), found in the periwinkle herb, is an antihypertensive drug used to treat hypertension and reduce peripheral resistance and blood pressure. Ajmalicine (Raubasine) is an adrenergi |
| MDL Number | MFCD00042748 |
| SMILES | COC(=O)C1=COC(C)C2CN3CCc4c([nH]c5ccccc45)C3CC12 |
| InChI | InChI=1S/C21H24N2O3/c1-12-16-10-23-8-7-14-13-5-3-4-6-18(13)22-20(14)19(23)9-15(16)17(11-26-12)21(24)25-2/h3-6,11-12,15-16,19,22H,7-10H2,1-2H3/t12-,15-,16+,19-/m0/s1 |
| InChI Key | GRTOGORTSDXSFK-XJTZBENFSA-N |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/9082_1_483_04_5.pdf |
| Bioactivity | Ajmalicine (Raubasine) is found in herbs of Catharanthus roseus, is an antihypertensive drug used in the treatment of high blood pressure, decreases peripheral resistance and blood pressure[1].Ajmalicine (Raubasine) is an adrenolytic drug which preferentially blocks alpha 1-adrenoceptor than alpha 2-adrenoceptor[2].Ajmalicine (Raubasine) is an reversible non-competitive nicotine receptor antagonist with an IC50 of 72.3 μM[3].Ajmalicine (Raubasine) acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2[4]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Neuronal Signaling >> AChE References [1]. Wink, Michael; Roberts, M. W. (1998). Alkaloids: biochemistry, ecology, and medicinal applications. New York: Plenum Press. ISBN 0-306-45465-3. [2]. Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 Oct 30;106(1):203-5. [3]. Pereira DM, et al. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine. 2010 Jul;17(8-9):646-52. [4]. • Demichel P, et al. Effects of raubasine stereoisomers on pre- and postsynaptic alpha-adrenoceptors in the rat vas deferens. Br J Pharmacol. 1984 Oct;83(2):505-10 Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 524.0±50.0 °C at 760 mmHg Melting Point 258°C (rough estimate) Molecular Formula C21H24N2O3 Molecular Weight 352.427 Flash Point 270.7±30.1 °C Exact Mass 352.178680 PSA 54.56000 LogP 2.88 Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.656 InChIKey GRTOGORTSDXSFK-XJTZBENFSA-N SMILES COC(=O)C1=COC(C)C2CN3CCc4c([nH]c5ccccc45)C3CC12 |
| Use of | Ajmalicine (Raubasine) is found in herbs of Catharanthus roseus, is an antihypertensive drug used in the treatment of high blood pressure, decreases peripheral resistance and blood pressure[1].Ajmalicine (Raubasine) is an adrenolytic drug which preferentially blocks alpha 1-adrenoceptor than alpha 2-adrenoceptor[2].Ajmalicine (Raubasine) is an reversible non-competitive nicotine receptor antagonist with an IC50 of 72.3 μM[3].Ajmalicine (Raubasine) acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2[4]. Properties Articles36 Name Raubasine Synonym More Synonyms Ajmalicine Biological Activity Description Ajmalicine (Raubasine) is found in herbs of Catharanthus roseus, is an antihypertensive drug used in the treatment of high blood pressure, decreases peripheral resistance and blood pressure[1].Ajmalicine (Raubasine) is an adrenolytic drug which preferentially blocks alpha 1-adrenoceptor than alpha 2-adrenoceptor[2].Ajmalicine (Raubasine) is an reversible non-competitive nicotine receptor antagonist with an IC50 of 72.3 μM[3].Ajmalicine (Raubasine) acts preferentially at postsynaptic sites, competitively antagonizes the effect of noradrenaline on postsynaptic alpha-adrenoceptor with a pA2 value of 6.57, blocks the inhibitory effect of clonidine with an pA2 value of 6.2[4]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Signaling Pathways >> Neuronal Signaling >> AChE References [1]. Wink, Michael; Roberts, M. W. (1998). Alkaloids: biochemistry, ecology, and medicinal applications. New York: Plenum Press. ISBN 0-306-45465-3. [2]. Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 Oct 30;106(1):203-5. [3]. Pereira DM, et al. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine. 2010 Jul;17(8-9):646-52. [4]. • Demichel P, et al. Effects of raubasine stereoisomers on pre- and postsynaptic alpha-adrenoceptors in the rat vas deferens. Br J Pharmacol. 1984 Oct;83(2):505-10 Chemical & Physical Properties Molecular Formula C21H24N2O3 Exact Mass 352.178680 PSA 54.56000 Index of Refraction 1.656 InChIKey GRTOGORTSDXSFK-XJTZBENFSA-N |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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