CAS Number82186-77-4
Synonyms(±)-2-(Dibutylamino)-1-((9Z)-2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl)ethanol; (±)-2,7-Dichloro-9-((Z)-p-chlorobenzylidene)-α-((dibutylamino)methyl)fluorene-4-methanol; (Z)-2-(Dibutylamino)-1-(2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl)ethanol; Benflumetol; Lumefantrine; 2-(Dibutylamino)-1-[(9Z)-2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]ethanol
Molecular FormulaC30H32Cl3NO
Molecular Weight528.94
Purity≥98 (HPLC)%
Density1.252
Boiling Point642.5±55.0 °C at 760 mmHg
Melting Point129-131ºC
Appearancepowder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 82186-77-4 |
| Catalog No. | 2A-0202338 |
| Chinese Name | 苯芴醇 |
| Synonyms | (±)-2-(Dibutylamino)-1-((9Z)-2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl)ethanol; (±)-2,7-Dichloro-9-((Z)-p-chlorobenzylidene)-α-((dibutylamino)methyl)fluorene-4-methanol; (Z)-2-(Dibutylamino)-1-(2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl)ethanol; Benflumetol; Lumefantrine; 2-(Dibutylamino)-1-[(9Z)-2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]ethanol |
| Molecular Formula | C30H32Cl3NO |
| Molecular Weight | 528.94 |
| Purity | ≥98 (HPLC) |
| Density | 1.252 |
| Boiling Point | 642.5±55.0 °C at 760 mmHg |
| Melting Point | 129-131ºC |
| Appearance | powder |
| Storage Condition | Refrigerator |
| Application | Lumefantrine is an antimalarial drug used in combination with Artemether as a first- and second-line antimalarial drug. |
| HTC | 2922199090 |
| PubChem ID | 329817625 |
| MDL Number | MFCD05662268 |
| SMILES | CCCCN(CCCC)CC(O)c1cc(Cl)cc2C(=C/c3ccc(Cl)cc3)\c4cc(Cl)ccc4-c12 |
| InChI | 1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15- |
| InChI Key | DYLGFOYVTXJFJP-MYYYXRDXSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | Transport |
| MSDS | msds/9333_1_82186_77_4.pdf |
| Bioactivity | Lumefantrine is an antimalarial drug, used in combination with Artemether. The artemether-lumefantrine (AL) as the first- and second-line anti-malarial drugs. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Ndounga M, et al. Artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in Congolese children under 10 years old living in a suburban area: a randomized study. Malar J. 2015 Oct 29;14(1):423. Chemical & Physical Properties Density 1.252 Boiling Point 642.5±55.0 °C at 760 mmHg Melting Point 129-131ºC Molecular Formula C30H32Cl3NO Molecular Weight 528.940 Flash Point 342.3±31.5 °C Exact Mass 527.154968 PSA 23.47000 LogP 11.37 Vapour Pressure 0.0±2.0 mmHg at 25°C Index of Refraction 1.634 InChIKey DYLGFOYVTXJFJP-MYYYXRDXSA-N SMILES CCCCN(CCCC)CC(O)c1cc(Cl)cc2c1-c1ccc(Cl)cc1C2=Cc1ccc(Cl)cc1 Storage condition Refrigerator |
| Use of | Lumefantrine is an antimalarial drug, used in combination with Artemether. The artemether-lumefantrine (AL) as the first- and second-line anti-malarial drugs. Properties Articles56 Name lumefantrine Synonym More Synonyms Lumefantrine Biological Activity Description Lumefantrine is an antimalarial drug, used in combination with Artemether. The artemether-lumefantrine (AL) as the first- and second-line anti-malarial drugs. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection References [1]. Ndounga M, et al. Artesunate-amodiaquine versus artemether-lumefantrine for the treatment of acute uncomplicated malaria in Congolese children under 10 years old living in a suburban area: a randomized study. Malar J. 2015 Oct 29;14(1):423. Chemical & Physical Properties Exact Mass 527.154968 PSA 23.47000 LogP 11.37 Index of Refraction 1.634 InChIKey DYLGFOYVTXJFJP-MYYYXRDXSA-N Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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