CAS Number16506-27-7
SynonymsTreanda (TN); 4-{5-[bis(2-chloroethyl)amino]-1-methyl-2-benzimidazolyl} butyric acid; 4-[5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butanoic acid; Bendamustin; 4-<1-Methyl-5-<bis(2-chlorethyl)amino>benzimidazolyl-(2)>butansaeure; Bendamustinum [Latin]; SDX 105; Bendamustina [Spanish]; Bendamustine; Bendamustine (INN); UNII-9266D9P3PQ; 4-{5-[bis-(2-chloro-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acid; 4-{5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl}butanoic acid
Molecular FormulaC16H21O2N3Cl2
Molecular Weight358.27
Purity98%
Density1.3±0.1 g/cm3
Boiling Point585.2±50.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 16506-27-7 |
| Catalog No. | 2A-9009330 |
| Chinese Name | 宾达氮芥 |
| Synonyms | Treanda (TN); 4-{5-[bis(2-chloroethyl)amino]-1-methyl-2-benzimidazolyl} butyric acid; 4-[5-[bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl]butanoic acid; Bendamustin; 4-<1-Methyl-5-<bis(2-chlorethyl)amino>benzimidazolyl-(2)>butansaeure; Bendamustinum [Latin]; SDX 105; Bendamustina [Spanish]; Bendamustine; Bendamustine (INN); UNII-9266D9P3PQ; 4-{5-[bis-(2-chloro-ethyl)-amino]-1-methyl-1H-benzoimidazol-2-yl}-butyric acid; 4-{5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl}butanoic acid |
| Molecular Formula | C16H21O2N3Cl2 |
| Molecular Weight | 358.27 |
| Purity | 98 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 585.2±50.0 °C at 760 mmHg |
| Storage Condition | 2-8°C, dry |
| Application | Bendamustine (SDX-105 free base), a purine analog, is a DNA cross-linker. Bendamustine activates the DNA damage response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolic |
| HTC | 2933990090 |
| MDL Number | MFCD00866481 |
| SMILES | Cn1c(CCCC(=O)O)nc2cc(N(CCCl)CCCl)ccc21 |
| InChI | InChI=1S/C16H21Cl2N3O2.ClH/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23;/h5-6,11H,2-4,7-10H2,1H3,(H,22,23);1H |
| InChI Key | YTKUWDBFDASYHO-UHFFFAOYSA-N |
| MSDS | msds/9330_1_16506_27_7.pdf |
| Use of | Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties[1]. Properties Name 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid Synonym More Synonyms Bendamustine Biological Activity Description Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties[1]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA Alkylator/Crosslinker DNA Alkylator/Crosslinker[1] References [1]. Leoni LM, et al. Bendamustine (Treanda) displays a distinct pattern of cytotoxicity and unique mechanistic features compared with other alkylating agents. Clin Cancer Res. 2008 Jan 1;14(1):309-17. [2]. Cives M, et al. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe. Cell Signal. 2013 May;25(5):1108-17. [3]. Ackler S, et al. Navitoclax (ABT-263) and bendamustine ± rituximab induce enhanced killing of non-Hodgkin's lymphoma tumours in vivo. Br J Pharmacol. 2012 Oct;167(4):881-91. Chemical & Physical Properties Exact Mass 357.101074 PSA 58.36000 Index of Refraction 1.599 InChIKey YTKUWDBFDASYHO-UHFFFAOYSA-N Safety Information HS Code 2933990090 Precursor & DownStream Precursor 7 CAS#:3543-74-6 5-(Bis(2-hydrox... CAS#:3543-75-7 Bendamustine Hy... CAS#:3543-73-5 1-METHYL-5-AMIN... CAS#:369-36-8 2-Fluoro-5-nitr... DownStream 1 CAS#:109882-25-9 Methyl 4-{5-[bi... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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