CAS Number1568-80-5
Synonyms2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi<1H-indene>-6,6'-diol; 6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobisindane; (2,2,3,3-tetrafluoropropoxy)acetic acid; 6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane; 2,2,3,3-Tetrafluor-propyloxy-essigsaeure; 3,3,3',3'-tetramethyl-1,1'-spirobisindane-6,6'-diol; 6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan; SPIROBIINDANE
Molecular FormulaC21H24O2
Molecular Weight308.42
Density1.21±0.1 g/cm3(Predicted)
Boiling Point478.5℃ at 760 mmHg
Melting Point213-214 °C
Appearancewhite solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1568-80-5 |
| Catalog No. | 2A-9093269 |
| Chinese Name | 3,3,3',3'-四甲基-1,1'-螺BI(茚满)-6,6'-二醇 |
| Synonyms | 2,2',3,3'-Tetrahydro-3,3,3',3'-tetramethyl-1,1'-spirobi<1H-indene>-6,6'-diol; 6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobisindane; (2,2,3,3-tetrafluoropropoxy)acetic acid; 6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane; 2,2,3,3-Tetrafluor-propyloxy-essigsaeure; 3,3,3',3'-tetramethyl-1,1'-spirobisindane-6,6'-diol; 6,6'-dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan; SPIROBIINDANE |
| Molecular Formula | C21H24O2 |
| Molecular Weight | 308.42 |
| Density | 1.21±0.1 g/cm3(Predicted) |
| Boiling Point | 478.5℃ at 760 mmHg |
| Melting Point | 213-214 °C |
| Appearance | white solid |
| Storage Condition | Store sealed at 2-8℃ |
| Application | HIV-1 integrase inhibitor 8 is an HIV-1 integrase (HIV-1 integrase) inhibitor, compound 8. |
| HTC | 2906299090 |
| PubChem ID | 636109 |
| MDL Number | MFCD01412945 |
| SMILES | CC1(C)CC2(CC(C)(C)c3ccc(O)cc32)c2cc(O)ccc21 |
| InChI | InChI=1S/C21H24O2/c1-19(2)11-21(17-9-13(22)5-7-15(17)19)12-20(3,4)16-8-6-14(23)10-18(16)21/h5-10,22-23H,11-12H2,1-4H3 |
| InChI Key | SICLLPHPVFCNTJ-UHFFFAOYSA-N |
| MSDS | msds/93269_1_1568_80_5.pdf |
| Use of | HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1]. Properties Name 2,2',3,3'-tetrahydro-3,3,3',3'-tetramethyl-1,1'-Spirobi(1H-indene)-6,6'-diol Synonym More Synonyms HIV-1 integrase inhibitor 8 Biological Activity Description HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8[1]. Related Catalog Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> HIV Integrase In Vitro HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 µM and 200 µM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 µM[1]. The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 µM and 200 µM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays[1]. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells[1]. References [1]. Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family.J Med Chem Chemical & Physical Properties Molecular Formula C21H24O2 Exact Mass 308.17800 PSA 40.46000 LogP 4.74650 InChIKey SICLLPHPVFCNTJ-UHFFFAOYSA-N Safety Information HS Code 2906299090 Synthetic Route bisphenol A HIV-1 integrase... Literature: Chen, Wei-Fu; Lin, Hsing-Yo; Dai, Shenghong A. Organic Letters, 2004 , vol. 6, # 14 p. 2341 - 2343 bisphenol A HIV-1 integrase... Literature: US4701567 A1, ; bisphenol A Perfluoroheptan... HIV-1 integrase... Literature: US4701567 A1, ; Precursor & DownStream Precursor 9 CAS#:80-05-7 bisphenol A CAS#:375-92-8 Perfluoroheptan... CAS#:354-88-1 Pentafluoroetha... CAS#:101-84-8 Diphenyl oxide DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2906299090 other aromatic alcohols. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff:5.5%. General tariff:30.0% |
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