CAS Number1271738-62-5
Synonyms4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2,3-d]pyrimidine; 4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-propylthieno[2,3-d]pyrimidine; 4-[4-(5,5-Dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine; MI-2
Molecular FormulaC18H25N5S2
Molecular Weight375.56
Density1.4±0.1 g/cm3
Boiling Point538.0±60.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1271738-62-5 |
| Catalog No. | 2A-9093265 |
| Chinese Name | 4-[4-(4,5-二氢-5,5-二甲基-2-噻唑基)-1-哌嗪基]-6-丙基噻吩并[2,3-d]嘧啶 |
| Synonyms | 4-[4-(5,5-dimethyl-4H-1,3-thiazol-2-yl)piperazin-1-yl]-6-propylthieno[2,3-d]pyrimidine; 4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-propylthieno[2,3-d]pyrimidine; 4-[4-(5,5-Dimethyl-4,5-dihydro-1,3-thiazol-2-yl)-1-piperazinyl]-6-propylthieno[2,3-d]pyrimidine; MI-2 |
| Molecular Formula | C18H25N5S2 |
| Molecular Weight | 375.56 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 538.0±60.0 °C at 760 mmHg |
| Storage Condition | -20°C |
| Application | MI-2 inhibits Menin-MLL interaction with an IC50 of 446±28 nM. |
| HTC | 2934999090 |
| PubChem ID | 85329947 |
| MDL Number | MFCD22575021 |
| SMILES | CCCc1cc2c(N3CCN(C4=NCC(C)(C)S4)CC3)ncnc2s1 |
| InChI | InChI=1S/C18H25N5S2/c1-4-5-13-10-14-15(20-12-21-16(14)24-13)22-6-8-23(9-7-22)17-19-11-18(2,3)25-17/h10,12H,4-9,11H2,1-3H3 |
| InChI Key | SRQYLNYQAPCPIR-UHFFFAOYSA-N |
| MSDS | msds/93265_1_1271738_62_5.pdf |
| Use of | Properties Name 4-(4-(5,5-Dimethyl-4,5-dihydrothiazol-2-yl)piperazin-1-yl)-6-propylthieno[2,3-d]pyrimidine Synonym More Synonyms MI-2 Biological Activity Related Catalog Signaling Pathways >> Epigenetics >> Histone Methyltransferase Research Areas >> Cancer References [1]. Grembecka J, et al. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nature Chemical Biology (2012), 8(3), 277-284. Chemical & Physical Properties Molecular Formula C18H25N5S2 Exact Mass 375.155121 PSA 98.16000 Index of Refraction 1.712 InChIKey SRQYLNYQAPCPIR-UHFFFAOYSA-N Safety Information HS Code 2934999090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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