CAS Number78574-94-4
SynonymsAstramembrangenin; (3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol; Cycloastragenol; (3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol; Cyclosieversigenin; Cyclogalegigenin
Molecular FormulaC30H50O5
Molecular Weight490.72
Density1.2±0.1 g/cm3
Boiling Point617.2±55.0 °C at 760 mmHg
Melting Point241.0 to 245.0 °C
AppearanceSolid;White to Almost white powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 78574-94-4 |
| Catalog No. | 2A-9093119 |
| Chinese Name | 环黄芪醇 |
| Synonyms | Astramembrangenin; (3β,6α,9β,16β,20R,24R)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol; Cycloastragenol; (3β,6α,9β,16β,20R,24S)-20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol; Cyclosieversigenin; Cyclogalegigenin |
| Molecular Formula | C30H50O5 |
| Molecular Weight | 490.72 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 617.2±55.0 °C at 760 mmHg |
| Melting Point | 241.0 to 245.0 °C |
| Appearance | Solid;White to Almost white powder to crystal |
| Storage Condition | 0-10°C; avoid heating |
| Application | Astramembrangenin is a triterpenoid saponin compound that is a hydrolyzate of the active ingredient in Astragalus membranaceus (Fisch.) Bunge. Astramembrangenin is orally safe and has a broad range of |
| HTC | 2942000000 |
| PubChem ID | 36630649 |
| SMILES | CC(C)(O)C1CCC(C)(C2C(O)CC3(C)C4CC(O)C5C(C)(C)C(O)CCC56CC46CCC23C)O1 |
| InChI | InChI=1S/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21-,22-,23-,26+,27-,28+,29-,30+/m0/s1 |
| InChI Key | WENNXORDXYGDTP-UOUCMYEWSA-N |
| Use of | Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge[1].Astramembrangenin is orally safe and has broad Extensive pharmacological effects, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties[2].Astramembrangenin has antiaging properties, CAG stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Cycloastragenol (CAG) may have a novel therapeutic role in depression[2]. Properties Name Cycloastragenol Synonym More Synonyms Cycloastragenol Biological Activity Description Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus (Fisch.) Bunge[1].Astramembrangenin is orally safe and has broad Extensive pharmacological effects, including telomerase activation, telomere elongation, anti-inflammatory and anti-oxidative properties[2].Astramembrangenin has antiaging properties, CAG stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Cycloastragenol (CAG) may have a novel therapeutic role in depression[2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease References [1]. Ip FC, et al. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014;22(1):52-63. [2]. Yu Y, et al. Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 2018 Sep;16(3):2175-2182. [3]. Sun C, et al. Cycloastragenol mediates activation and proliferation suppression in concanavalin A-induced mouse lymphocyte pan-activation model. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):131-139. Chemical & Physical Properties Molecular Formula C30H50O5 Exact Mass 490.365814 PSA 90.15000 Index of Refraction 1.582 InChIKey WENNXORDXYGDTP-UOUCMYEWSA-N Safety Information RIDADR NONH for all modes of transport RTECS GX8265000 HS Code 2942000000 |
| Transport Info | Product Name: Cycloastraganol |
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