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Apraclonidine hydrochloride structure, CAS 73218-79-8

Apraclonidine hydrochloride

CAS Number73218-79-8

SynonymsUNII-D2VW67N38H; Iopidine ophthalmic solution; MFCD00135922; 2-(4-Amino-2,6-dichlorophenylimino)imidazolidine; 2-[(4-amino-2,6-dichlorophenyl)imino]imidazolidine monohydrochloride; APRACLONIDINE HYDROCHLORIDE; ALO-2145; 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine,hydrochloride; p-aminoclonidine hydrochloride; NC 14 hydrochloride; 2-[(2,6-dichloro-4-aminophenyl)imino]imidazolidine hydrochloride; p-aminoclonidine; mono hydrochloride; Apraclonidine HCl

Molecular FormulaC9H11Cl3N4

Molecular Weight281.57

Purity99%

Density1.63 g/cm3

Boiling Point395.5ºC at 760 mmHg

Melting Point>230ºC

Flash Point

Appearancesolid

EINECS

MSDSChineseEnglish

Symbol6.1(b)

Signal WordWarning

Cat. No.: 2A-9009218 Purity: 99%
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Quality Control of [ 73218-79-8 ] Purity: 99% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number73218-79-8
Catalog No.2A-9009218
Chinese Name盐酸安普乐定
SynonymsUNII-D2VW67N38H; Iopidine ophthalmic solution; MFCD00135922; 2-(4-Amino-2,6-dichlorophenylimino)imidazolidine; 2-[(4-amino-2,6-dichlorophenyl)imino]imidazolidine monohydrochloride; APRACLONIDINE HYDROCHLORIDE; ALO-2145; 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine,hydrochloride; p-aminoclonidine hydrochloride; NC 14 hydrochloride; 2-[(2,6-dichloro-4-aminophenyl)imino]imidazolidine hydrochloride; p-aminoclonidine; mono hydrochloride; Apraclonidine HCl
Molecular FormulaC9H11Cl3N4
Molecular Weight281.57
Purity99
Density1.63 g/cm3
Boiling Point395.5ºC at 760 mmHg
Melting Point>230ºC
Appearancesolid
Water Solubility45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 m
Storage Condition2-8°C
PackagingIII
ApplicationApraclonidine hydrochloride (ALO 2145) is a selective α2 and weak α1 receptor agonist that can effectively reduce intraocular pressure in humans. Apraclonidine hydrochloride is a topical eye drop that
HTC2933290090
SMILES[Cl-].Clc1c(c(cc(c1)N)Cl)NC2=NCCN2.[H+]
InChI1S/C9H10Cl2N4.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2,12H2,(H2,13,14,15);1H
InChI KeyOTQYGBJVDRBCHC-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard Symbols6.1(b)
MSDSmsds/9218_1_73218_79_8.pdf
Use ofApraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid[1][2]. Properties Name apraclonidine hydrochloride Synonym More Synonyms Iopidine Biological Activity Description Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution and has the ability to elevate the eye lid[1][2]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vitro Apraclonidine hydrochloride (ALO 2145) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects[2]. In Vivo Apraclonidine hydrochloride (ALO 2145) is effective in animal models of elevated IOP as well as glaucoma in humans. The ocular hypotensive effects of Apraclonidine are usually attributed to reduced aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery[2]. References [1]. Wijemanne S, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci. 2017;376:129‐132. [2]. Searles RV, et al. Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. Pharmacology. 1999;58(4):220‐226. Chemical & Physical Properties Exact Mass 280.00500 PSA 62.44000 LogP 3.16730 InChIKey OTQYGBJVDRBCHC-UHFFFAOYSA-N Stability Moisture Sensitive Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 1,4-Benzenediamine, 2,6-dichloro-N(sup 1)-(4,5-dihydro-1H-imidazol-2-yl)-, monohydrochloride CAS REGISTRY NUMBER : 73218-79-8 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year: 24,557,1988 Safety Information GHS06, GHS08 Signal Word Danger Hazard Statements H300-H370 Precautionary Statements Missing Phrase - N15.00950417-P308 + P311 Target Organs Cardio-vascular system Hazard Codes T: Toxic; RIDADR UN 2811 WGK Germany 3 Packaging Group III Hazard Class 6.1(b) HS Code 2933290090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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