CAS Number66711-21-5
Synonymspara-aminoclonidine; 4-Aminoclonidine; Apraclonidinum; Iopidine; Apraclonidina; Apraclonidinum [INN-Latin]; 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine; 2-(4-amino-2,6-dichlorophenylamino)-2-imidazoline; [3H]-p-aminoclonidine; 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine; p-amino clonidine; Apraclonidina [INN-Spanish]; MFCD00865638; Aplonidine
Molecular FormulaC9H10Cl2N4
Molecular Weight281.57
Purity98%
Density1.63g/cm3
Boiling Point395.5ºC at 760mmHg
Appearancesolid | white
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 66711-21-5 |
| Catalog No. | 2A-9009217 |
| Chinese Name | 阿可乐定 |
| Synonyms | para-aminoclonidine; 4-Aminoclonidine; Apraclonidinum; Iopidine; Apraclonidina; Apraclonidinum [INN-Latin]; 2,6-dichloro-1-N-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine; 2-(4-amino-2,6-dichlorophenylamino)-2-imidazoline; [3H]-p-aminoclonidine; 2,6-Dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)benzene-1,4-diamine; p-amino clonidine; Apraclonidina [INN-Spanish]; MFCD00865638; Aplonidine |
| Molecular Formula | C9H10Cl2N4 |
| Molecular Weight | 281.57 |
| Purity | 98 |
| Density | 1.63g/cm3 |
| Boiling Point | 395.5ºC at 760mmHg |
| Appearance | solid | white |
| Water Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 m |
| Storage Condition | 2-8°C |
| Application | Apironidine hydrochloride (ALO 2145) is a selective α2 and weak α1 receptor agonist that can effectively reduce intraocular pressure in human eyes. Aprotidine hydrochloride is a topical ophthalmic sol |
| HTC | 2933290090 |
| MDL Number | MFCD00135922 |
| SMILES | Clc1c(c(cc(c1)N)Cl)N=C2NCCN2.Cl |
| InChI | 1S/C9H10Cl2N4.ClH/c10-6-3-5(12)4-7(11)8(6)15-9-13-1-2-14-9;/h3-4H,1-2,12H2,(H2,13,14,15);1H |
| InChI Key | OTQYGBJVDRBCHC-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/9217_1_66711_21_5.pdf |
| Use of | Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution[1][2]. Properties Name apraclonidine Synonym More Synonyms Apraclonidine Biological Activity Description Apraclonidine hydrochloride (ALO 2145), a selective α2 and weak α1 receptor agonist activity, effectively lowers intraocular pressure (IOP) in human eyes. Apraclonidine hydrochloride is a topical ophthalmic solution[1][2]. Related Catalog Research Areas >> Infection Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease In Vitro Apraclonidine hydrochloride (ALO 2145) is more commonly used topically for glaucoma, as it penetrates the cornea and blood-brain barrier to a lesser extent and, thus, has fewer adverse systemic effects[2]. In Vivo Apraclonidine hydrochloride (ALO 2145) is effective in animal models of elevated IOP as well as glaucoma in humans. The ocular hypotensive effects of Apraclonidine are usually attributed to reduced aqueous humor synthesis and vasoconstrictor actions at the anterior segment branches of the ophthalmic artery. Apraclonidine (1.15%, single instillation) inhibits 98% of PGE2-induced aqueous flare elevationy[2][3] . Animal Model: male rabbits[3] Dosage: 1.15% Administration: Apraclonidine (1.15%, single instillation) Result: Inhibited PGE2-induced elevation of aqueous flare in pigmented rabbits. References [1]. Subhashie Wijemanne, et al. Apraclonidine in the treatment of ptosis. J Neurol Sci [2]. R V Searles, et al. Aqueous humor dynamics in anesthetized rats infused with intracameral apraclonidine. Pharmacology. 1999 Apr;58(4):220-6. [3]. Yoriko Hayasaka, et al. Effects of topical antiglaucoma eye drops on prostaglandin E(2)-induced aqueous flare elevation in pigmented rabbits. Invest Ophthalmol Vis Sci Chemical & Physical Properties Exact Mass 244.02800 PSA 62.44000 LogP 2.36530 Appearance of Characters solid | white InChIKey IEJXVRYNEISIKR-UHFFFAOYSA-N Safety Information Hazard Codes T WGK Germany 3 HS Code 2933290090 Synthetic Route Total: 1 Page N-(2,6-Dichloro... CAS#:65936-26-7 Apraclonidine CAS#:66711-21-5 Literature: Van Dort; Neubig; Counsell Journal of medicinal chemistry, 1987 , vol. 30, # 7 p. 1241 - 1244 2,6-dichloro-1-... CAS#:73218-65-2 Apraclonidine CAS#:66711-21-5 Literature: Journal of medicinal chemistry, , vol. 30, # 7 p. 1241 - 1244 Precursor & DownStream Precursor 2 CAS#:65936-26-7 N-(2,6-Dichloro... CAS#:73218-65-2 2,6-dichloro-1-... DownStream 1 CAS#:81913-29-3 Clonidine 4-iso... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| Antazoline phosphate | 154-68-7 | 2A-9009210 |
| Anthralin | 1143-38-0 | 2A-9009211 |
| Antide | 112568-12-4 | 2A-9009212 |
| Apalcillin | 63469-19-2 | 2A-9009214 |
| Apiin | 26544-34-3 | 2A-9009215 |
| Apraclonidine hydrochloride | 73218-79-8 | 2A-9009218 |
| Apramycin | 37321-09-8 | 2A-9009219 |
| Apricot Seed | 2A-300303 | 2A-9009220 |
| Aprindine hydrochloride | 33237-74-0 | 2A-9009221 |
| Aprinocid | 2A-300305 | 2A-9009222 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS