CAS Number82626-01-5
SynonymsALPIDEM; 6-Chloro-2-(p-chlorophenyl)-N,N-dipropylimidazo(1,2-a)pyridine-3-acetamide; Ananxyl; SL 80.0342-00; Alpidemum [Latin]
Molecular FormulaC21H23Cl2N3O
Molecular Weight404.34
Purity98%
Density1.24g/cm3
Melting Point136-138ºC
AppearanceWhite to off-white solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 82626-01-5 |
| Catalog No. | 2A-9009130 |
| Chinese Name | 阿尔吡登 |
| Synonyms | ALPIDEM; 6-Chloro-2-(p-chlorophenyl)-N,N-dipropylimidazo(1,2-a)pyridine-3-acetamide; Ananxyl; SL 80.0342-00; Alpidemum [Latin] |
| Molecular Formula | C21H23Cl2N3O |
| Molecular Weight | 404.34 |
| Purity | 98 |
| Density | 1.24g/cm3 |
| Melting Point | 136-138ºC |
| Appearance | White to off-white solid |
| Water Solubility | DMSO: ≥10mg/mL |
| Storage Condition | Refrigerator |
| Application | Alpidem selectively binds to the α1β2γ2 subunit containing GABAA receptors, with an IC50 of 17 nM, and exerts an anti-anxiety effect [1]. |
| SMILES | CCCN(CCC)C(=O)Cc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12 |
| InChI | InChI=1S/C21H23Cl2N3O/c1-3-11-25(12-4-2)20(27)13-18-21(15-5-7-16(22)8-6-15)24-19-10-9-17(23)14-26(18)19/h5-10,14H,3-4,11-13H2,1-2H3 |
| InChI Key | JRTIDHTUMYMPRU-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| Bioactivity | Alpidem selectively binds to α1β2γ2 subunit-containing GABAA receptor with an IC50 of 17 nM and exerts anxiolytic effect[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor References [1]. Faure-Halley C, et al. Expression and properties of recombinant alpha 1 beta 2 gamma 2 and alpha 5 beta 2 gamma 2 forms of the rat GABAA receptor. Eur J Pharmacol. 1993 Aug 15;246(3):283-7. Chemical & Physical Properties Density 1.24g/cm3 Melting Point 136-138ºC Molecular Formula C21H23Cl2N3O Molecular Weight 404.34 Exact Mass 403.12200 PSA 37.61000 LogP 5.49920 Index of Refraction 1.606 InChIKey JRTIDHTUMYMPRU-UHFFFAOYSA-N SMILES CCCN(CCC)C(=O)Cc1c(-c2ccc(Cl)cc2)nc2ccc(Cl)cn12 Storage condition Refrigerator Water Solubility DMSO: ≥10mg/mL |
| Use of | Alpidem selectively binds to α1β2γ2 subunit-containing GABAA receptor with an IC50 of 17 nM and exerts anxiolytic effect[1]. Properties Articles28 Name 2-[6-chloro-2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]-N,N-dipropylacetamide Synonym More Synonyms alpidem Biological Activity Description Alpidem selectively binds to α1β2γ2 subunit-containing GABAA receptor with an IC50 of 17 nM and exerts anxiolytic effect[1]. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor References Chemical & Physical Properties Exact Mass 403.12200 PSA 37.61000 LogP 5.49920 Index of Refraction 1.606 InChIKey JRTIDHTUMYMPRU-UHFFFAOYSA-N Storage condition Refrigerator |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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