CAS Number122852-69-1
SynonymsAlosetron hydrochloride; LOTRONEX; MFCD03453647; Alosetron HCl; Alosetron (Hydrochloride)
Molecular FormulaC17H19ClN4O
Molecular Weight330.82
Purity98%
Density1.34g/cm3
Boiling Point648.1ºC at 760 mmHg
Melting Point288-291ºC
Appearanceoff-white powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 122852-69-1 |
| Catalog No. | 2A-9009125 |
| Chinese Name | 盐酸阿洛司琼 |
| Synonyms | Alosetron hydrochloride; LOTRONEX; MFCD03453647; Alosetron HCl; Alosetron (Hydrochloride) |
| Molecular Formula | C17H19ClN4O |
| Molecular Weight | 330.82 |
| Purity | 98 |
| Density | 1.34g/cm3 |
| Boiling Point | 648.1ºC at 760 mmHg |
| Melting Point | 288-291ºC |
| Appearance | off-white powder |
| Storage Condition | Refrigerator |
| Application | Alosetron is a 5-HT3 receptor antagonist that can treat irritable bowel syndrome. |
| HTC | 2933990090 |
| MDL Number | C17H19ClN4O |
| SMILES | Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O.Cl |
| InChI | InChI=1S/C17H18N4O.ClH/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2;/h3-6,10H,7-9H2,1-2H3,(H,18,19);1H |
| InChI Key | FNYQZOVOVDSGJH-UHFFFAOYSA-N |
| Hazard Symbols | Transport |
| MSDS | msds/9125_1_122852_69_1.pdf |
| Bioactivity | Alosetron Hcl is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.IC50 Value: Target: 5-HT ReceptorAlosetron has an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract. While being a 5-HT3 antagonist like ondansetron, it is not classified or approved as an antiemetic. Since stimulation of 5-HT3 receptors is positively correlated with gastrointestinal motility, alosetron's 5-HT3 antagonism slows the movement of fecal matter through the large intestine, increasing the extent to which water is absorbed, and decreasing the moisture and volume of the remaining waste products. From Wikipedia. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease References [1]. Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome By Spiller, Robin C. From Current Opinion in Pharmacology (2011), 11(1), 68-74. [2]. Lucak SL. Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant irritable bowel syndrome. Therap Adv Gastroenterol. 2010 May;3(3):165-72. [3]. Lewis JH. Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective. Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):13-29. [4]. Turgeon DK, Tayeh N, Fontana RJ. Acute hepatitis associated with alosetron (Lotronex). J Clin Gastroenterol. 2005 Aug;39(7):641-2. [5]. Miller DP, Alfredson T, Cook SF, Sands BE, Walker AM. Incidence of colonic ischemia, hospitalized complications of constipation, and bowel surgery in relation to use of alosetron hydrochloride. Am J Gastroenterol. 2003 May;98(5):1117-22. Chemical & Physical Properties Density 1.34g/cm3 Boiling Point 648.1ºC at 760 mmHg Melting Point 288-291ºC Molecular Formula C17H19ClN4O Molecular Weight 330.812 Flash Point 345.8ºC Exact Mass 330.124725 PSA 53.92000 LogP 3.14820 Vapour Pressure 1.1E-16mmHg at 25°C InChIKey FNYQZOVOVDSGJH-UHFFFAOYSA-N SMILES Cc1[nH]cnc1CN1CCc2c(c3ccccc3n2C)C1=O.Cl Storage condition Refrigerator |
| Use of | Alosetron Hcl is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.IC50 Value: Target: 5-HT ReceptorAlosetron has an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract. While being a 5-HT3 antagonist like ondansetron, it is not classified or approved as an antiemetic. Since stimulation of 5-HT3 receptors is positively correlated with gastrointestinal motility, alosetron's 5-HT3 antagonism slows the movement of fecal matter through the large intestine, increasing the extent to which water is absorbed, and decreasing the moisture and volume of the remaining waste products. From Wikipedia. Properties Articles25 Name alosetron hydrochloride Synonym More Synonyms Alosetron hydrochloride Biological Activity Description Alosetron Hcl is a Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.IC50 Value: Target: 5-HT ReceptorAlosetron has an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract. While being a 5-HT3 antagonist like ondansetron, it is not classified or approved as an antiemetic. Since stimulation of 5-HT3 receptors is positively correlated with gastrointestinal motility, alosetron's 5-HT3 antagonism slows the movement of fecal matter through the large intestine, increasing the extent to which water is absorbed, and decreasing the moisture and volume of the remaining waste products. From Wikipedia. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease References [1]. Targeting the 5-HT3 receptor in the treatment of irritable bowel syndrome By Spiller, Robin C. From Current Opinion in Pharmacology (2011), 11(1), 68-74. [2]. Lucak SL. Optimizing outcomes with alosetron hydrochloride in severe diarrhea-predominant irritable bowel syndrome. Therap Adv Gastroenterol. 2010 May;3(3):165-72. [3]. Lewis JH. Alosetron for severe diarrhea-predominant irritable bowel syndrome: safety and efficacy in perspective. Expert Rev Gastroenterol Hepatol. 2010 Feb;4(1):13-29. [4]. Turgeon DK, Tayeh N, Fontana RJ. Acute hepatitis associated with alosetron (Lotronex). J Clin Gastroenterol. 2005 Aug;39(7):641-2. [5]. Miller DP, Alfredson T, Cook SF, Sands BE, Walker AM. Incidence of colonic ischemia, hospitalized complications of constipation, and bowel surgery in relation to use of alosetron hydrochloride. Am J Gastroenterol. 2003 May;98(5):1117-22. Chemical & Physical Properties Exact Mass 330.124725 PSA 53.92000 LogP 3.14820 InChIKey FNYQZOVOVDSGJH-UHFFFAOYSA-N Storage condition Refrigerator |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 United Nations number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 United Nations shipping name European land transport hazard regulations: TOXIC SOLID, ORGANIC, N.O.S. IMDG: TOXIC SOLID, ORGANIC, N.O.S. International air transport hazard regulations: Toxic solid, organic, n.o.s. 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special precautions No data available |
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