| Chemical & Physical Properties | |
|---|---|
| CAS Number | 490-59-5 |
| Catalog No. | 2A-9009116 |
| Chinese Name | Alloxazine |
| Synonyms | Alloxazin; 1H-benzo[g]pteridine-2,4-dione; Alloxazine |
| Molecular Formula | C10H6N4O2 |
| Molecular Weight | 214.18 |
| Purity | 96 |
| Density | 1.509g/cm3 |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | Alloxan is a selective A2b antagonist. Alloxan can completely block 5'N-ethylcarboxamide adenosine (NECA)-mediated accumulation of cyclic adenosine monophosphate, with an IC50 of 2.9 μM. Alloxan can b |
| EINECS | 207-714-3 |
| HTC | 2933990090 |
| PubChem ID | 24890699 |
| MDL Number | MFCD00005020 |
| SMILES | O=C1NC(=O)c2nc3ccccc3nc2N1 |
| InChI | 1S/C10H6N4O2/c15-9-7-8(13-10(16)14-9)12-6-4-2-1-3-5(6)11-7/h1-4H,(H2,12,13,14,15,16) |
| InChI Key | HAUGRYOERYOXHX-UHFFFAOYSA-N |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| MSDS | msds/9116_1_490_59_5.pdf |
| Bioactivity | Alloxazine is a selective A2b antagonist. Alloxazine can completely block 5'N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Target IC50: 2.9 μM (AMP)[1] In Vitro Alloxazine (0-30 μM, 20 min) inhibits cyclic AMP production in PGT-β cells[1]. Cell Viability Assay[1] Cell Line: PGT-β cells Concentration: 0-30 μM Incubation Time: 20 min Result: Inhibited the cyclic AMP generation concentration-dependently with an IC IC50 of 2.9 μM. In Vivo Alloxazine (1 µmol/L, 0-20 min) suppresses NECA-induced vasodilation[2]. Animal Model: 250-320 g male Sprague-Dawley rats[2] Dosage: 1 µmol/L Administration: Cortical surface suffusion; 1 µmol/L once Result: Significantly suppressed vasodilation with increased EC25 value of 0.60 µmol/L. References [1]. Brackett LE, Daly JW. Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol. 1994 Mar 2;47(5):801-14. [2]. Shin HK, et al. Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H339-44. Chemical & Physical Properties Density 1.509g/cm3 Molecular Formula C10H6N4O2 Molecular Weight 214.18000 Exact Mass 214.04900 PSA 91.50000 LogP 0.15960 Index of Refraction 1.699 InChIKey HAUGRYOERYOXHX-UHFFFAOYSA-N SMILES O=c1[nH]c(=O)c2nc3ccccc3nc2[nH]1 Storage condition -20℃ |
| Use of | Alloxazine is a selective A2b antagonist. Alloxazine can completely block 5'N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2]. Properties Name alloxazine Synonym More Synonyms Alloxazine;Isoalloxazine Biological Activity Description Alloxazine is a selective A2b antagonist. Alloxazine can completely block 5'N-Ethylcarboxamido adenosine (NECA)-mediated cyclic AMP accumulation with an IC50 of 2.9 μM. Alloxazine can be used for the research of cancer[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor IC50: 2.9 μM (AMP)[1] References [1]. Brackett LE, Daly JW. Functional characterization of the A2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol. 1994 Mar 2;47(5):801-14. [2]. Shin HK, et al. Role of adenosine A(2B) receptors in vasodilation of rat pial artery and cerebral blood flow autoregulation. Am J Physiol Heart Circ Physiol. 2000 Feb;278(2):H339-44. Chemical & Physical Properties Molecular Formula C10H6N4O2 Exact Mass 214.04900 PSA 91.50000 LogP 0.15960 Index of Refraction 1.699 InChIKey HAUGRYOERYOXHX-UHFFFAOYSA-N Storage condition -20℃ |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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